Yazar "Bulbuller, Nurullah" seçeneğine göre listele

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    Prognostic Value of Preoperative CEA and CA 19-9 Levels in Patients with Colorectal Cancer
    (H G E Update Medical Publishing S A, 2011) Basbug, Murat; Arikanoglu, Zulfu; Bulbuller, Nurullah; Cetinkaya, Ziya; Aygen, Erhan; Akbulut, Sami; Satici, Omer
    Aims: This study evaluated the prognostic value of the preoperative CEA and CA 19-9 levels on the survival time and TNM staging in patients with colorectal cancer. Methodology: We retrospectively analyzed 172 patients who underwent potentially curative resection of colorectal cancer (TNM I-III) between 2002 and 2007. Clinical data were obtained from medical charts, including age, gender, tumor location, TNM stage, mortality, follow-up duration, and preoperative CEA and CA 19-9 levels. A CEA >= 5ng/mL was defined as abnormal (CEA+), while the cutoff for the CA19-9 was set at 37U/mL (CA19-9+). Patients were categorized into Groups I-IV according to the preoperative serum CEA and CA 19-9 levels [CEA/CA 19-9: (-/-), (+/-), (-/+), and (+/+)]. Results: Follow-up was longest for Group I (p<0.001). Mortality rates were higher in Groups V' (p<0.001) and II (p<0.008). On comparing patients according to CEA levels, survival was longer in the CEA-negative group (p=0.0001). On comparison according to CA 19-9 levels, survival was greater in the CA 19-9-negative group (p=0.0001). While CEA (p<0.016) and CA 19-9 (p<0.001) were independent prognostic factors according to the logistic regression analysis, TNM (p=0.002), CEA (p<0.001), and CA 19-9 (p<0.001) were prognostic factors in the ROC curve analysis. Conclusions: Colorectal cancer patients with elevated levels of both CEA and CA 19-9 have a significantly poorer prognosis than those with normal levels of these tumor markers.
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    A rare case of trichobezoar: Rapunzel's syndrome
    (Aves Press Ltd, 2011) Kirkil, Cuneyt; Boyuk, Abdullah; Bulbuller, Nurullah; Aygen, Erhan; Karabulut, Koray
    The clinical condition caused by bezoars with long tail named as Rapunzel's syndrome. We present a case with the Rapunzel's syndrome, and also briefly review the relevant literature in this article. We diagnosed a gastric trichobezoar that filling the entire stomach and extending to the forth part of duodenum in a 21 years-old-girl who complained about abdominal pain and weight loss. The bezoar removed by coeliotomy and gastrotomy.
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    The role of High Mobility Group Box 1 (HMGB1) in colorectal cancer
    (Int Scientific Literature, Inc, 2014) Suren, Dinc; Yildirim, Mustafa; Demirpence, Ozlem; Kaya, Vildan; Alikanoglu, Arsenal Sezgin; Bulbuller, Nurullah; Yildiz, Mustafa
    Background: HMGB1, the most important member of the high mobility group box protein family, is a nuclear protein with different functions in the cell; it has a role in cancer progression, angiogenesis, invasion, and metastasis development. We studied the expression of HMGB1 and whether it is a prognostic factor in colorectal carcinoma. Material/Methods: The study included 110 cases that were histopathologically diagnosed with colorectal carcinoma from the tissue samples acquired by surgical resection and biopsy in Antalya Education and Research Hospital between 2008 and 2012. HMGB1 expression was examined via immunohistochemical method. Results: HMGB1 expression was evaluated as negative in 32 (44.4%) of the patients and as positive in 40 (55.6%) patients. There was no relation between the HMGB1 expression and sex, age, tumor invasion depth, and histological type. However, a significant relation was detected between the HMGB1 expression and lymph node status, metastasis status, and stage (p:<0.001, p:<0.001, p:<0.001, respectively). Similar results were obtained for the relations between the HMGB1 and histological grade, perineural invasion, lymphovascular invasion, and lymphocytic response (p<0.001, p<0.001, p<0.001, and p<0.001, respectively). Conclusions: The results of our study demonstrate that HMGB1 overexpression has a significant role in tumor progression (especially migration of tumor cells) and tumor ability to metastasize in colorectal cancers; thus, it corroborates the idea that it might be an important prognostic factor.