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Öğe Are oxidative stress markers useful to distinguish schizoaffective disorder from schizophrenia and bipolar disorder?(Cambridge Univ Press, 2014) Bulbul, Feridun; Virit, Osman; Alpak, Gokay; Unal, Ahmet; Bulut, Mahmut; Kaya, Mehmet Cemal; Altindag, AbdurrahmanObjective Schizoaffective disorder is a disease with both affective and psychotic symptoms. In this study, we aimed to compare oxidative metabolism markers of schizoaffective disorder, bipolar disorder and schizophrenic patients. Furthermore, we also aimed to investigate whether schizoaffective disorder could be differentiated from schizophrenia and bipolar disorder in terms of oxidative metabolism. Methods Total oxidant status (TOS) and total antioxidant status (TAS) were measured in the blood samples that were collected from schizoaffective patients (n = 30), bipolar disorder patients (n = 30) and schizophrenic patients (n = 30). Oxidative stress index (OSI) was calculated by dividing TOS by TAS. Results TOS and OSI were found to be higher in patients with schizoaffective disorder compared with those in schizophrenia and bipolar disorder patients. TAS was not significantly different between the groups. Conclusion Schizoaffective disorder was found to be different from bipolar disorder and schizophrenia in terms of oxidative parameters. This result may indicate that schizoaffective disorder could differ from bipolar disorder and schizophrenia in terms of biochemical parameters. Increased TOS levels observed in schizoaffective disorder may suggest poor clinical course and may be an indicator of poor prognosis.Öğe Catatonia associated globe vesicale(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2012) Sahin, Sengul; Bulbul, Feridun; Unal, Ahmet; Bulut, Mahmut; Virit, Osman; Altindag, Abdurrahman; Savas, HalukCatatonia is a syndrome that includes catalepsy, waxy flexibility, stupor, negativism, mutism, and echolalia. Side effects such as dehydration, malnutrition, constipation, flexion contractors and rhabdomyolysis may develop due to catatonia. Here, we aimed to report a case of globe vesicale associated with catatonia and the successful treatment of this case with benzodiazepine use and electroconvulsive therapy (ECT) treatment. As a result, the globe vesicale should be considered in patients presenting with catatonia and if present it should be treated urgently.Öğe Electroconvulsive Therapy for Mood Disorders in Pregnancy(Lippincott Williams & Wilkins, 2013) Bulut, Mahmut; Bez, Yasin; Kaya, Mehmet Cemal; Copoglu, Umit Sertan; Bulbul, Feridun; Savas, Haluk AsumanElectroconvulsive therapy (ECT) offers a treatment option for mood disorders during pregnancy. We retrospectively examined 12 pregnant patients who were treated with ECT for their mood disorders. The mean +/- SD age of the patients was 28.1 +/- 4.8 years. The mean +/- SD number of ECTs performed was 9.8 +/- 4.5. The mean T SD Clinical Global Impression score was decreased from 6 to 2.6 +/- 0.7 with ECT. No significant adverse events were observed other than early delivery in one patient and pes ekinovarus deformity in a newborn that was most probably not related to ECT causally. Electroconvulsive therapy seems to be an effective and safe treatment option in pregnant patients with mood disorders.Öğe High Catalase and Low Thiol Levels in Adult-ADHD Patients(Kure Iletisim Grubu A S, 2014) Alpak, Gokay; Selek, Salih; Bulut, Mahmut; Bulbul, Feridun; Unal, Ahmet; Virit, Osman; Kilic, Osman Hasan TahsinObjective: The prevalence of Adult attention-deficit/hyperactivity disorder (A-ADHD) has been estimated as to be around 5%. There are several hypotheses regarding the etiology of ADHD. Although numerous researches have been conducted regarding neurobiology of pediatric ADHD, A-ADHD studies were relatively few. Many studies have indicated that oxidant mediated neuronal damage may play a role in the pathophysiology of various psychiatric disorders. Recently, oxidative stress has been studied in A-ADHD and there is an accumulating evidence to support its' role. In the present study, we aimed to evaluate catalase (CAT) and thiol levels in A-ADHD patients and compare with healthy controls. Materials-Methods: Twenty-five A-ADHD patients from Gaziantep University, diagnosed according to Turgay's Turkish version of Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale by two psychiatrists, and 25 healthy volunteer controls were included. The subjects strictly refrained from any substance intake and physical exercise after 08:00 p.m. on the day before collection. CAT and Thiol levels were measured in plasma samples of study groups. Results: Age, gender, and body mass indexes of patients and controls have shown homogeneity and there were no differences between the groups. Total score and subscores were not correlated with any of the mentioned biochemical parameters. The mean CAT levels in patients with ADHD were significantly higher and Thiol levels were lower than those of controls (<0.001, <0.001, respectively). When the comorbid patient group compared with pure A-ADHD patients in terms of CAT (11.49 +/- 0.28, 11.51 +/- 0.40, respectively) and thiol (0.22 +/- 0.05, 0.25 +/- 0.03, respectively) levels there were not found any significant differences (p=0.865, p=0.174, respectively). Conclusions: The results of the present study may indicate that thiol levels may be decreased with in reaction of increased CAT levels and thiol act like a pro-oxidant. This study may be considered as one of the initial phase studies that lighten the relationship between oxidative stress and A-ADHD.There is a need for further studies that will prove this relationship exactly.
