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    The effects of systemically administered methylprednisolone and recombinant human erythropoietin after acute spinal cord compressive injury in rats
    (Springer, 2006) Cetin, Abdurrahman; Nas, Kemal; Bueyuekbayram, Hueseyin; Ceviz, Adnan; Oelmez, Goenuel
    The study design was to decrease the damage of spinal cord on the experimentally induced acute spinal cord injury in rats. The objective of this study was to evaluate whether recombinant human erythropoietin (rHu-EPO) and methylprednisolone (MPSS) improve neurological function and histopathological changes if systemically administered after traumatic spinal cord injury. This study included 48 rats that underwent experimental SCI. Forty-eight animals were randomly divided into six groups. Animals constituted a moderate compression of 0.6 N that was produced by application of an aneurysm clip at level T3 for 1 min. rHu-EPO (1,000 and 3,000 U (Unit) per kg of body weight i.p.) and MPSS (30 mg/kg) were administered 5 min after injury, and control group was saline treated. (1) Control group (n=8), (2) MPSS group (n=8), (3) rHu-EPO 1,000 U group (n=8), (4) MPSS + rHu-EPO 1,000 U group (n=8), (5) rHu-EPO 3,000 U group (n=8), and (6) MPSS + rHu-EPO 3,000 U group (n=8). The neurological function and histopathology were evaluated at 24 and 72 h. According to the neurological functional test scores significant improvements between the control group and the other groups that had taken medical treatment were observed (P < 0.001). Histopathologically severe ischemic findings were observed in the control group. A significant decrease in ischemic damage was detected in MPSS + rHu-EPO 3,000 U group (P < 0.001). The most significant neurological functional and histopathological improvements were observed after systemical administration of MPSS + rHu-EPO 3,000 U and rHu-EPO 3,000 U. Furthermore, the MPSS + rHu-EPO 3,000 U group provides the most improved neurological functional and histopathological recovery.
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    Granular cell tumor of the esophagus and its endoscopic treatment
    (Turkish Soc Gastroenterology, 2007) Bayan, Kadim; Yilmaz, Serif; Tuezuen, Yekta; Can, Alper; Bueyuekbayram, Hueseyin
    [Abstract Not Available]
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    Intraperitoneal octenidindihydro-chloride-phenoxyethanol solution to prevent peritoneal adhesion formation in a rat peritonitis model
    (Wiley, 2007) Guezelsagqaltici, Nihat; Girgin, Sadullah; Gedik, Ercan; Bueyuekbayram, Hueseyin; Bac, Bilsel
    Background. Peritoneal adhesion is a common complication following abdominal surgery. Despite recent advances in diagnosis and treatment, it still presents a problem for the patients and surgeons. In the present study, we investigated the effects of octenidindihydro-chloride - phenoxyethanol (OCP) on peritoneal adhesions. Method. Rats were divided into four groups: Group 1 ( saline), Group 2 ( peritonitis plus saline), Group 3 ( OCP), and Group 4 ( peritonitis plus OCP). Peritonitis was induced in the rats of Groups 2 and 4. The abdominal cavities of the rats in Groups 1 and 2 were washed with saline, while those of the rats in Groups 3 and 4 were irrigated with 1: 10 OCP solution. Adhesion and fibrotic scores were determined by re-laparotomy after 21 days. Results. The adhesion scores in Groups 1 ( saline), 2 ( peritonitis plus saline), 3 (OCP) and 4 ( peritonitis plus OCP) were 3.30 +/- 0.94, 5.25 +/- 1.03, 1.12 +/- 0.83 and 0.28 +/- 0.48, respectively. Statistical analysis of adhesion scores revealed significant differences between groups, except between Groups 3 and 4 ( p = 0.265). Statistical analyses of grades of histopathological signs showed that Group 1 differed from Groups 2 and 4 ( p = 0.004, p = 0.003, respectively); Group 2 differed from Groups 3 and 4 ( p = 0.001, p = 0.001, respectively). On the other hand, differences between Group 3 and Groups 1 and 4 were not significant ( p = 0.06, p = 0.08, respectively). Conclusion. OCP decreased the peritoneal adhesion formation macroscopically and microscopically in the presence or absence of peritonitis. Peritoneal defects due to trauma are to be left open and OCP diluted 1: 1 should not be used intraperitoneally.
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    A rare cause of anemia in a patient with end stage renal disease
    (Ortadogu Ad Pres & Publ Co, 2007) Sit, Dede; Kadiroglu, Ali Kemal; Kayabasi, Hasan; Bueyuekbayram, Hueseyin; Yilmaz, M. Emin; Isikoglu, Buenyamin
    The association of pulmonary hemorrhagic syndrome and end stage renal disease is a rare condition. Severe anemia that occurred suddenly in a 27 years old male patient who was undergoing chronic HD program was investigated. Platelet count was normal but bleeding time was prolonged. Pulmonary hemorrhagic syndrome was considered secondary to platelet dysfunction. The diagnosis was confirmed by pulmonary biopsy. The patient was successfully treated with conservative approach.