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  • Küçük Resim
    Öğe
    Eight-day methotrexate/folinic acid regime as single agent chemotherapy for low-risk gestational trophoblastic neoplasia: A retrospective study
    (Türkiye Klinikleri Yayınevi, 2022) Akgöl, Sedat; Oğlak, Süleyman Cemil; Tunç, Şeyhmus; Kahramanoğlu, Özge; Ölmez, Fatma; Kahramanoğlu, İlker; Budak, Mehmet Şükrü
    Objective: To evaluate the 8-day methotrexate (MTX)/folinic acid (FA) as a first-line chemotherapy regimen treatment in terms of complete regression of disease in women with low-risk gestational trophoblastic neoplasia (GTN). Material and Methods: All patients with low-risk GTN treated with an 8-day MTX/FA regimen were retrospectively included in the study. International Federation of Obstetrics and Gynecology and the modified World Health Organization Prognostic Scoring System were used to classify the risk of GTN. All women received diagnostic imaging evaluation before starting the treatment. The same MTX/FA regime was used repeating as a two-week cycle until normalization of the beta-human chorionic gonadotropin (ß-HCG), thus monthly ß-HCG follow-up was scheduled for up to 1 year. Results: Successful treatment was achieved in 56/66 (84.8%) patients. Nine (13.6%) women had resistance and 1 (1.6%) toxicity. The resistance patients were successfully treated with EMA-CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) protocol, whereas the patient who showed toxicity to the MTX/FA regime was successfully treated with actinomycin-D. Conclusion: Eight-day MTX/FA regime could be useful in low-risk GTN patients with good security margins. The toxicity rates in this protocol were determined as quite low. All resistance was treated successfully with the EMA-CO protocol.
  • [ X ]
    Öğe
    KLİNİĞİMİZDE TANI ALAN PARSİYEL VE KOMPLET MOL HİDATİFORM OLGULARININ RETROSPEKTİF ANALİZİ
    (2016) Kanat, Mine Pektaş; Budak, Mehmet Şükrü; Kaya, Cihan; Şentürk, Mehmet Baki; Tunç, Senem Yaman; Akgöl, Sedat; Göklü, Mehmet Rıfat
    Amaç: Hastanemizde son iki yılda tanı konulan mol hidatiform olgularını epidemiyolojik ve klinik bakımdan değerlendirmeyi amaçlamaktadır. Yöntemler: Bu çalışmada, 1 Ocak 2012 ve 1 Ocak 2014 tarihleri arasında hastanemizde gerçekleştirilen histopatolojik inceleme sonucu tanı konulan 87 mol hidatiform olgusu geriye dönük olarak incelenmiştir.Bulgular: Değerlendirilen 87 mol hidatiform olgusunun 52'sine (% 59.8) parsiyel mol ve 35'ine (% 40.2) komplet mol tanısı konuldu. Komplet mol olgularının ortalama serum beta-human koryonik gonadotropin (?-HCG) seviyeleri anlamlı olarak yüksekti (p=0.017). Mol hidatiform olgularına ait klinik ve patolojik tanıların birbiriyle ilişkili olmadığı belirlenmiştir (?2=4.490, p=0.213). Benzer biçimde, ultrasonografik ve patolojik tanılar da birbiriyle ilişkili değildi (?2 = 4.663, p=0.198). İncelenen olguların serum ?-HCG düzeyleriyle yaşı, graviditesi, paritesi ve abortus sayısı arasında anlamlı bir korelasyon bulunamadı. Sonuç: Ülkemizde mol hidatiform görülme sıklığı ile ilgili literatürdeki farklı çalışmalarda farklı veriler bulunmaktadır. Özellikle ileri yaş kadınlarda molar gebelik sıklığının azaltılma
  • Küçük Resim
    Öğe
    PALM-COEIN classification system of FIGO vs the classic terminology in patients with abnormal uterine bleeding
    (Via Medica, 2021) Kahveci, Bekir; Budak, Mehmet Şükrü; Ege, Serhat; Obut, Mehmet; Bağlı, İhsan; Oğlak, Süleyman Cemil; Vardar, Mehmet Ali
    Objectives: To evaluate the FIGO's novel classification system versus the classic terminology in patients with abnormal uterine bleeding. Material and methods: A retrospective study was carried out between August 2015 and September 2019 in the Health Sciences University Gazi Yasargil Training and Research Hospital. The pathology reports of the patients were classified according to the PALM-COEIN method and were compared with classical terminology. The operated patients with fibroids reported in the pathology results were classified as subgroups of fibroids. Results: Evaluation was made of a total of 515 women with abnormal uterine bleeding. According to the classical terminology, 137 (26.6%) patients were defined with hypermenorrhea, 74 (14.4%) with menorrhagia, 57 (11.1%) with metrorrhagia, and 246 (47.8%) with menometrorrhagia. In the PALM-COEIN classification system, polyps were determined in 84 (16.3%) cases, adenomyosis in 228 [diffuse adenomyosis:196 (38.1%), local adenomyosis:32 (6.2%)], leiomyoma in 386 [submucous:161 (31.1%), other types: 225 (43.9%)], and malignancy and hyperplasia in 47 (9.1%). Conclusions: The classical terminology for abnormal uterine bleeding is insufficient in terms of etiological pathologies in non-pregnant women of reproductive age. The widespread use of this novel system for the abnormal uterine bleeding classification will provide a more useful communication between physicians and researchers.
  • [ X ]
    Öğe
    TB Clinicopathological Evaluations of Cervical Polyps
    (2015) Budak, Mehmet Şükrü; Şentürk, Mehmet Baki; Yıldırım, Ayhan; Durukan, Ömer Birol; Polat, Mesut; Çakmak, Yusuf
    sAmaç: Klinik pratikte servikal poliplerin nasıl yö- lnetileceği yaygın bir tartışma konusudur. Rando- smize kontrollü prospektif çalışmalar etik olarak ,doğru bulunmadığından bu konudaki çalışmalar -retrospektif olmaktadır. Malin transformasyon po- ntansiyeli pre ve postmenapozal hastalarda endişe toluşturmaktadır. Bu çalışmada, servikal polip gö- yrülen hastalarda, semptom ve menopoz durumuna ngöre polipektomi piyeslerinin patoloji sonuçlarının -karşılaştırılması amaçlanmıştır.