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    Carvacrol prevents methotrexateinduced renal oxidative injury and renal damage in rats
    (2014) Bozkurt M.; Em S.; Oktayoglu P.; Turkcu G.; Yuksel H.; Sariyildiz M.A.; Caglayan M.
    Purpose: The purpose of this study was to investigate the effect of carvacrol (CAR) on methotrexate (MTX)-induced renal damage in rats. Methods: Twenty-four male rats were equally divided into three groups: group I, control treatment; group II, MTX-treated; and group III, MTX+CAR-treated. A single dose of CAR (73 mg/kg) was administered intraperitoneally to group III on the First day of the experiment and a single dose of MTX (20 mg/kg) was administered intraperitoneally to groups II and III on the second day of the experiment. Blood samples and kidney tissue were obtained from each animal on day 8 for the measurement of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Light microscopy was used for histopathological examination of kidney specimens. Results: MDA, TOS and OSI levels were significantly greater in the group receiving MTX alone relative to the control animals, while the TAS level was significantly reduced in the MTX group compared with the control group. The administration of CAR was associated with significantly decreased MDA, TOS, and OSI levels and increased TAS levels relative to the rats treated with MTX alone. Animals treated with CAR exhibited decreased tubular degeneration and architectural impairment relative to animals treated with MTX alone; however, the difference in histological scores did not meet the threshold of statistical significance. Conclusions: MTX treatment results in oxidative damage to the rat kidney; damage which is partially abrogated by the administration of CAR. © 2014 CIM.
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    Dermatofibrosarcoma protuberans: Analysis of 14 cases treated with wide excision
    (2013) Durgun M.; Selçuk C.T.; Özalp B.; Özakplnar H.R.; Seven E.; Bozkurt M.; Tellioğlu A.T.
    Introduction: Dermatofbrosarcoma protuberans is a painless, slow growing, plaque or noduler shaped fbrocystic tumor taking origin from dermis and subcutaneous tissue. In this study 14 patients operated because of dermatofbrosar-coma protuberans has been evaluated for sufcient surgical border and reccurence.Material and Methods: Patiens included in this study were operated between January 2007-October 2012 in Dlşkapl Ylldlrlm Beyazit Training and Research Hospital Department of Plastic Reconstructive and Aesthetic Surgery and Dicle University Plastic Reconstrucitve and Aesthetic Surgery diagnosed with dermatofbrosarcoma protuberans. Patients evaluated for age, sex, reconstructive method and postoperative follow duration. Lesions excised widely including 4 cm of intact skin border and fasia below.Results: Among 14 patients who were included 6 were male 8 were female. Age of patients varied between 18-89 with an average of 45 years. Lesions were on trunk in 9 patients (%64), on upper extremity in 3 patients (%21), and on lower extremity in 2 patients (%15). Average follow up duration were 21 months. A patient with a lesion on wrist recieved radiotherapy additional to surgery. No reccurence observed in any patient.Conclusions: In our study, a wide excision of skin with 4 cm can provide histopathologically negative border.
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    The effects of pomegranate and carvacrol on methotrexate-induced bone marrow toxicity in rats
    (The Canadian Society for Clinical Investigation, 2014) Şen V.; Bozkurt M.; Söker S.; Ece A.; Güneş A.; Uluca Ü.; Söker M.
    Purpose: The aim of this study was to evaluate the effects of pomegranate (PMG) extract and carvacrol (CARV) on methotrexate (MTX)-induced oxidative stress and bone marrow toxicity. Methods: Wistar albino rats (32 rats) were divided into four groups (n=8): Group 1 was control; Group 2 was given a single intraperitoneal injection of methotrexate (20 mg/kg); Group 3 was treated with carvacrol (73 mg/kg i.p.) one day before MTX (20 mg/kg i.p.) injection; and, Group 4 received a single dose of MTX (20 mg/kg i.p) while PMG was administered orally for seven days at 225 mg/kg. After animals were euthanized, blood samples were taken to evaluate hematological parameters and oxidative stress. In addition, the femur was cropped and bone marrow was extracted for examination. Results: White blood cell count, hemoglobin, hematocrit and platelet count were found to be decreased in the MTX group, but these changes were prevented in the groups that received CARV and PMG. Furthermore, decreased bone marrow cellularity was found in the groups treated with MTX, whereas the PMG and CARV groups had cellularity similar to controls. Strikingly, oxidative stress increased in the MTX group, but was ultimately decreased in the rats that received the antioxidants PMG and CARV. Conclusion: Carvacrol and PMG were found to be protective against methotrexate induced oxidative bone marrow damage. Use of these antioxidants, in combination with chemotherapeutics, may help to reduce some adverse effects of methotrexate. © 2014 CIM.
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    The evaluation of relationship between plasma asymmetric dimethylarginine (ADMA) and aortic stiffness in patients with systemic sclerosis
    (2013) Aritürk Z.; Dağ Ş.; Ali Elbey M.; Kaya H.; Erta F.; Bozkurt M.; Çevik R.
    Objective: Endothelial dysfunction and vasculopathy are crucial pathogenic factors in systemic sclerosis. Increased concentrations of plasma asymmetric dimethylarginine (ADMA) may also contribute to endothelial dysfunction in patients with systemic sclerosis. We evaluated the relationship between ADMA and aortic elastic properties in patients with systemic sclerosis. Material and Method: Plasma ADMA levels were measured in 30 patients with systemic sclerosis (28 females, mean age 40.7±11.6) and 30 healthy subjects (27 females, mean age 40.6±13). Aortic stiffness was determined with echocardiography. Results: In patients with systemic sclerosis, the mean value of ADMA was 0.53±0.13?mol/l compared with 0.46±0.15 ?mol/l for control group. Systolic blood pressure, pulse pressure and aortic 'strain' were found to be higher in patients with systemic sclerosis (p=0.027, p=0.048, p=0.037, respectively), diyastolic blood pressure and aortic distensibility was found lower in systemic sclerosis (p=0.039, p=0.045, respectively). There was no significant correlations between ADMA and aortic 'strain'. Conclusion: ADMA serum levels were increased in patients with systemic sclerosis, but no significant correlation was found between ADMA and aort's elastic structure (aortic 'strain', distensibility, and aortic stiffness index).
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    Gluteal necrosis due to diaper pressure: Case report
    (2011) Kapi E.; Bozkurt M.
    We encounter fewer cases of pressure sores in the pediatric age group when compared to adults. There are often problems such as additional systemic disease, immobility and sensory impairment in the pediatric case in which the pressure sore develops. In the cases in which there are not such problems, the pressure sore development emerges due to unfamiliar reasons. At this study, the case in the infantile period in which the pressure sore develops in the gluteal area after diaper usage is presented. The case has been hospitalized and debridement has been applied to the gluteal necrotic tissue defect, after the wound care program repairment with partial thickness skin graft has been implemented. Parents taking care of the baby have to make tiny distinctions in order to solve the problem of the baby reacting abnormally because the baby does not have the ability to talk or of any reason. As monitored in our case, the parents of the baby a part of whose body was under pressure were late to find a solution and the necrotic defects occurred has affected baby's health negatively. On the other hand, such carelessness cause problems that parents would be held responsible juridically and cause problems to impose penal sanctions. Therefore the role of the media and social organizations essential for educating and raising the awareness of the parents about this case is important. In the literature review we have made, we have not come across with any parameter about the pressure sore developing due to diaper pressure in babyhood. Therefore, our case is rather interesting in terms of its unusual etiology.
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    Serum osteocalcin, bone alkaline phosphatase and cathepsin k levels of patients with postmenopausal ra: Correlation with disease activity and joint damage
    (Acta Medica Mediterranea, 2014) Batmaz I.; Çakirca G.; Sariyildiz M.A.; Dilek B.; Mete N.; Hamidi C.; Bozkurt M.
    Objective: To investigate serum levels of osteocalcin (OC), bone alkaline phosphatase (BALP) and cathepsin K in patients with postmenopausal rheumatoid arthritis (RA) and to evaluate the relationship between these markers and disease activity and radiological joint damage. Material and methods: Forty six postmenopausal women diagnosed with RA according to the criteria of American College of Rheumatology and 42 postmenopausal healthy women who have similar age range with the patient group were involved into the study. Disease activity was measured with Disease Activity Score (DAS 28). Furthermore, Larsen score was used to evaluate radiological damage. Results: OC and BALP levels were not different between postmenopausal patients with RA and control group (p >0.05). However, levels of cathepsin K were elevated in serum of the patients with postmenopausal RA when compared with that of the healthy control group (p<0.05). In addition, the elevated serum levels of cathepsin K were positively correlated with disease activity and joint destruction (p<0.05). No significant relationship was observed between OC and BALP levels and disease activity and joint destruction (p >0.05). Conclusions: Cathepsin K may be a valuable parameter to assess disease prognosis in postmenopausal RA.
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    Serum prolidase enzyme activity and oxidative status in patients with scleroderma
    (Acta Medica Mediterranea, 2014) Bozkurt M.; Dağ Ş.; Oktayoglu P.; Em S.; Yüksel H.; Çağlayan M.; Sariyildiz M.A.
    Objective: To assess serum prolidase enzyme activity and oxidative stress in patients with scleroderma (also known as systemic sclerosis, or SSc) and determine its relationship with serum oxidative status. Methods: The study population consisted of SSc patients (n = 21) and healthy participants (n =29). Serum prolidase enzyme activity, total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and paraoxonase-1 (PON-1) levels were compared betweeen the two groups. Results: The mean duration of SSc involvement was 5 years; and the mean modified Rodnan skin score was 16. No statistically significant differences existed between the SSc groups and the control participants in terms of age, gender, TAS, PON-1, and haematocrit levels. Serum prolidase activity, OSI, and TOS levels were statistically significantly higher in SSc patients in comparison with controls participants. Also serum prolidase activity was statistically higher in Raynaud's phenomenon positive patients than Raynaud's phenomenon negative patients. But no correlation emerged between the serum prolidase activity and modified Rodnan Skin Score (P=0.235, r=0.304). Conclusion: High prolidase activity may indicate critical biological activities relevant to pathological events in SSc, and this activity may be a biological indicator of disease. Further studies are needed to verify these findings.