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    Assessment of the laboratory transmission of brucellosis in an endemic region
    (Acta Medica Mediterranea, 2014) Deveci O.; Tekin R.; Aslan E.; Hosoglu S.; Bozkurt F.; Dayan S.; Demirpence O.
    Objectives: Laboratory-acquired brucellosis (LB) has been one of the most commonly reported laboratory-associated bacterial infections in both endemic and non-endemic countries. Brucellosis is endemic in Turkey. The aim of this study is to describe the risk factors of LB among laboratory healthcare workers. Material and method: A regional survey study was conducted by face-to-face interview in 7 hospitals from Diyarbakir, Mardin and Batman province, in southeaster Anatolia in Turkey. A structured survey questionnaire was administered to the Laboratory healthcare workers, employed in infectious diseases clinics and microbiology departments, who were at risk of Brucella infection. Result: Of the 136 laboratory workers, 13 (9.5%) had a history of laboratory-acquired brucellosis. Logistic regression analysis identified factors independently associated with an increased risk of LB including lack of biosafety cabinet (P<0.005) and a lack of compliance in the use of the same (P<0.005). Using a biosafety cabinet (P<0.005), existence of biosafety cabinet (P<0.005), full adherence to glove use (P<0.005) and male gender(P<0.005) were found to be protective factors. Conclusion: Increased adherence to personal protective equipment and use of biosafety cabinets should be priority targets to prevent LB.
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    Carbapenem resistance in Acinetobacter baumannii: Where is it heading?
    (2013) Deveci O.; Dal T.; Tekin R.; Bozkurt F.; Tekin A.; Dayan S.
    In the context of the substantial increase in antibiotic resistance rates of Acinetobacter baumannii, we aimed to evaluate the susceptibility rate changes of A. baumannii strains for carbapenems. A. baumannii strains isolated from patients diagnosed with healthcare-associated infections between 2007-2010 were included. A total of 127 A. baumannii strains [53 (42%) from the intensive care unit and 74 (58%) from the non-intensive care unit] were isolated. Conventional methods and an automated microbiology system were used for identification. Susceptibility testing was studied by Kirby-Bauer disk diffusion method. In 2007, five of 26 strains, in 2008, 18 of 31, in 2009, 10 of 35, in 2010, and 20 of 35 were obtained from intensive care unit patients. The susceptibility rate for imipenem was 50% in 2007 but 20% in 2010, while for meropenem it was 55% in 2007 but 12% in 2010. Prevention and control of antibiotic resistance among Acinetobacter species needs antibiotic usage restrictions and infection control precautions.
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    Evaluation of mean platelet volume levels in patients with brucellosis
    (Anatolian Journal of Clinical Investigation, 2014) Bozkurt F.; Aslan E.; Devecİ Ö.; Tekİn R.
    Brucellosis is still an important infectious disease, specially in Turkey. During brucellosis there is an inflammation which causes increase in acute phase reactants. Mean platelet volume (MPV) has been shown as an inflammatory marker in some diseases. Our aim were to assess MPV levels of the patients with Brucellosis. Demographic data of the study groups and their complete blood counting, PLT, MPV, ESR, CRP (C-Reactive Protein) values and serum tube agglutination test (STAT) results were recorded. Before and after treatment MPV levels of 100 patients with brucellosis were evaluated comparing with control group’s MPV levels. The average age of patients was 31.1±15.3 and they were 48 (48%) male and 52 (52 %) female. The average age of control group was 35,2±10,5 and they were of 49 (49 %) male and 51 (51 %) female. ESR, MPV, red cell distribution width (RDW), Hemoglobin (Hgb), CRP, PLT and white blood cell (WBC) values were statistically different among groups. MPV levels and RDW values were significantly lower in the pre-treatment group compared with posttreatment ones. Spearman’s correlation analysis showed a significant negative correlation between CRP and MPV values. MPV levels may be useful in the management of patients with brucellosis. © 2014, Anatolian Journal of Clinical Investigation. All rights reserved.
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    [Fascioliasis and brucellosis in same patient].
    (2014) Deveci O.; Aslan E.; Tekin A.; Toka Özer T.; Tekin R.; Bozkurt F.; Çetinçakmak M.G.
    Brucellosis is a zoonotic infectious disease that can affect many organs and systems and leads to very different clinical circumstances. Brucellosis is rare in association with various infectious agents. Fascioliasis is a zoonotic disease caused by Fasciola hepatica, popularly referred to as a large leaf-shaped liver fluke. This case is a 39-year-old male patient, and his complaints began a week ago, which were chills, fever, abdominal pain, nausea, vomiting, weakness, sweating, and widespread pain. The patient was considered brucellosis in the preliminary diagnosis. Rose Bengal test and Wright test (1/640) were detected as positive. Due to patients having elevated liver enzymes, abdominal ultrasound was taken. A liver lesion was seen with abdominal ultrasound. So, abdominal computed tomography (CT) was taken. The CT result report came in the form that at the left lobe of the liver segment 2, largely necrosis that showed no contrast enhancement, approximately 61x63 mm in size (compatible with fascioliasis) is viewed. The patient's IHA test results, required for fascioliasis, were detected as 1/320 positive. Especially for zoonotic diseases in areas with high endemicity, it should be considered that more than one infectious agent can be present together in high-risk patients.
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    Non-invasive parameters in the assessment of liver fibrosis
    (Scientific Publishers of India, 2017) Dayan S.; Dal T.; Tekin R.; Deveci O.; Ipek D.; Ozcan N.; Bozkurt F.
    Liver biopsy and histopathological evaluation are the main methods to assess liver pathology. However, liver biopsy is not widely used due to implementation challenge. We aimed to investigate non-invasive parameters for evaluation of liver fibrosis in chronic Hepatitis B patients. A total of 65 patients who admitted to outpatient clinic and diagnosed as chronic hepatitis were included in this study. Liver puncture biopsy was performed for all patients and was evaluated according to the Modified Ishak Fibrosis Score. The patients without fibrosis or with mild and moderate fibrosis were evaluated as Group I (Stage O, I, II), the patients with advanced fibrosis were evaluated as Group II (stage III, IV, V, VI). Among 65 patients, 42 were male and 23 were female; 48 of the patients were in group I while 17 patients belonged to group II. Gamma-Glutamyl Transferase (GGT), Alkaline Phosphatase (ALP), Aspartat Transaminaz (AST) and Alanin Aminotransferaz (ALT) levels were significantly higher in Group II patients. In the assessment of liver fibrosis, liver biopsy remains the gold standard diagnostic method but AST, ALT, GGT, ALP parameters have contribution to this evaluation. Non-invasive testing may be useful in cases which biopsy cannot be performed or repeat biopsy required. © 2017, Scientific Publishers of India. All rights reserved.
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    The role of trace elements in Helicobacter pylori infected patients
    (2011) Bozkurt F.; Gulsun S.; Ustun C.; Geyik M.F.; Hosoglu S.
    Objective: To evaluate the effect of trace elements in patients with Helicobacter pylori associated chronic gastritis Design: Prospective study Settings: Clinical services of the clinical microbiology and infectious diseases and gastroenterology clinics at Dicle University, Turkey Subjects: A total of 92 patients with variable severity of chronic gastritis (45 Helicobacter pylori positive and 47 Helicobacter pylori negative gastritis) and 90 age and sex matched healthy subjects were included in the study conducted between October 2006 and November 2008. Intervention: Histopathologic examination, culture of Helicobacter pylori and urease tests were performed for each patient. The atomic absorption spectrophotometer was used in the measurement of trace elements in the serum. Main Outcome Measures: Serum copper and zinc levels were significantlyelevatedinpatientswithHelicobacter pylori associated gastritis compared to Helicobacter pylori negative gastritis and healthy controls (p < 0.0001). Serum copper, zinc and Cu/Zn levels in patients with Helicobacter pylori negative chronic gastritis was not significantlydifferentfromthe serum levels in healthy controls (p > 0.05). Conclusions: Our results suggest a relationship between Helicobacter pylori associated chronic gastritis and the elevation of trace element levels in serum. This study confirmsthattheelevation of trace element levels in serum (Cu and Zn levels) will be helpful in the diagnosis of Helicobacter pylori associated chronic gastritis in the abscence of invasive procedures, and is useful in predicting the severity of infection in patients with chronic gastritis.