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Alt ekstremite amputasyonlu hastalarda uyku kalitesi ve ilişkili faktörlerin değerlendirilmesi
(Türkiye Fiziksel Tıp ve Rehabilitasyon Derneği, 2015) Em, Serda; Batmaz, İbrahim; Karakoç, Mehmet; Aydın, Abdulkadir; Bozkurt, Mehtap; Çağlayan, Mehmet; Nas, Kemal
Amaç: Alt ekstremite amputasyonlu (AEA) hastalarda uyku kalitesini değerlendirmek ve uyku bozukluğu ile ilişkili faktörleri belirlemektir.Gereç ve Yöntemler: Bu çalışmaya AEA'lı 35 hasta ve 35 sağlıklı kontrol alındı. Çalışma grubunun demografik verileri kaydedildi. Uyku kalitesi Pittsburgh Uyku Kalitesi İndeksi (PUKİ) ile değerlendirildi. Amputasyonla ilişkili ağrı, Vizüel Analog Skala kullanılarak ölçüldü. Psikolojik durum Beck Depresyon Ölçeği (BDÖ) ve Beck Anksiyete Ölçeği (BAÖ) ile değerlendirildi.Bulgular: Hastalarda PUKİ'nin uyku süresi alt skoru dışında tüm alt skorları ve total skoru kontrol grubuna göre anlamlı olarak yüksekti. Total PUKİ skoru ile BDÖ (p<0,05) ve BAÖ (p<0,01) skoru korele idi. Multipl regresyon analizi ile yaş ve anksiyetenin uyku kalitesini belirlemede en önemli faktörler olduğu gösterildi (p<0,05). Sonuç: Çalışmamız kontrol grubuna göre AEA'lı hastalarının uyku kalitesinde bozulma olduğunu ve buna ek olarak yaş ve emosyonel durumun uyku kalitesiyle ilişkili olduğunu gösterdi. Bu nedenle ileri yaşta ve emosyonel durumu bozuk olan hastalarda çok yönlü tedavi yaklaşımları uyku bozukluğunu gidermek için gereklidir. Ancak uyku bozukluğunun nedenlerini ve genel sağlık üzerine etkilerini gösteren daha fazla hasta ile yapılmış ileri çalışmalara ihtiyaç vardır.
Ankilozan spondilitli hastalarda komorbit hastalıkların değerlendirmesi
(Dicle Üniversitesi Tıp Fakültesi, 2014) Em, Serda; Bozkurt, Mehtap; Çağlayan, Mehmet; Oktayoğlu, Pelin; Karakoç, Mehmet; Nas, Kemal
Amaç: Bu çalışmanın amacı ankilozan spondilit (AS) hastalarında komorbit hastalıkları ve bulunma oranlarını belirlemektir. Yöntemler: Bu çalışmaya 70 AS’li hasta, 70 romatoid artritli (RA) hasta ve 70 sağlıklı kontrol alındı. Demografik ve klinik özellikler kaydedildi. Tüm gruplar hipertansiyon, Aterosklerotik Kalp Hastalığı (ASKH), kalp yetmezliği, tiroid hastalıkları, akciğer hastalıkları, Tip2 diyabet ve serebrovasküler olay (SVO) açısından sorgulandı ve daha kapsamlı bilgi elde etmek için hasta kayıtları retrospektif olarak incelendi. Bulgular: Hasta ve kontrol grupları yaş, boy ve kilo bakımından benzerdi. AS’li hastalarda hipertansiyon görülme sıklığı, sağlıklı kontrollerden anlamlı olarak yüksekti (p<0.05). Fakat AS ve RA hastaları hipertansiyon açısından karşılaştırıldığında böyle bir farklılık gözlenmedi (p>0.05). AS ve RA’lı hastalarda ASKH ve kalp yetmezliği görülme sıklığı benzerdi ve AS hastaları kontrol grupları ile karşılaştırıldığında anlamlı farklılık yoktu. AS’li hastalarda tiroid hastalıkları %12.8 olarak görülürken, Tip2 diyabet sıklığı %11.4 idi ve sağlıklı kontrollerle AS hastaları karşılaştırıldığında bu iki hastalık açısından iki grup arasındaki fark anlamlıydı (p<0.05). Sonuç: AS’li hastalarda, sağlıklı kontrollere göre hipertansiyon, tiroid hastalıkları ve diyabet görülme sıklığı anlamlı derecede yüksekti. Ancak RA’lı hastalar ve AS’li hastalar arasında komorbit hastalık açısından anlamlı fark tespit edilmedi.
Assessment of Hand Functions in Patients with Chronic Hepatitis B
(Aves, 2014) Oktayoglu, Pelin; Tekin, Recep; Caglayan, Mehmet; Bozkurt, Mehtap; Em, Serda; Yildiz, Mehmet; Ucmak, Feyzullah
Objective: Motor dysfunction is an important clinical finding in patients with liver cirrhosis (LC), but there is no study assessing fine motor coordination in patients with chronic hepatitis B (CHB). We aimed to investigate hand functions and fingertip dexterity in patients with CHB. Materials and Methods: A total of 17 female and 15 male patients diagnosed with CHB without histopathological findings of cirrhosis were enrolled to the study; 21 female and 9 male healthy volunteers were included as a control group. Hand grip strength was assessed by Jamar hand dynamometer. Three kinds of pinch strength of fingers were assessed by Jamar pinchmeter. Functional status was evaluated by using the Stanford Health Assessment Questionnaire (HAQ). Duruoz Hand Index (DHI) was used to assess the hand functions. Fingertip dexterity was evaluated by Purdue pegboard test. Results: Bilateral hand grip strength and pinch strength were not statistically different from controls (p>0.05). There was also no significant difference between the categories of the Purdue pegboard test between the groups. HAQ scores of patients were higher than controls (p< 0.05). Conclusion: Hand functions are not influenced in patients with CHB. Disruptions in the functional status of patients with CHB may be due to fatigue and depression, which are usually seen in chronic liver diseases.
Assessment of Serum S100 Protein Levels in Patients with Fibromyalgia
(Clinical & Exper Rheumatology, 2014) Cavas, Husamettin; Oktayoglu, Pelin; Verim, Sabahattin; Em, Serda; Caglayan, Mehmet; Bozkurt, Mehtap; Yildiz, Ismail
[Abstract Not Available]
Assessment of sexual function and quality of life in patients with lower limb amputations
(Ios Press, 2019) Em, Serda; Karakoc, Mehmet; Sariyildiz, Mustafa Akif; Bozkurt, Mehtap; Aydin, Abdulkadir; Cevik, Remzi; Nas, Kemal
BACKGROUND: Diseases causing disabilities lead to sexual dysfunction. However, studies that evaluate sexual functions in patients with traumatic lower limb amputations (LLA) are limited and controversial. OBJECTIVE: The objective is to evaluate sexual functions in male patients with LLA and to identify factors that might contribute to sexual dysfunction. The hypothesis is that male patients with LLA would experience worse sexual and emotional functioning and consequently emotional impairment that consequently influenced the sexual function. METHODS: Sixty men with traumatic LLA and 60 healthy men were assessed according to the International Index of Erectile Function (IIEF) scoring system. Emotional state was assessed by the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), and the quality of life by the Short Form-36 Health Survey (SF-36). RESULTS: Patients had significantly lower scores in the IIEF total score and subscores in comparison with the controls. Intercourse satisfaction scores were significantly higher (p < 0.05) in patients with trans-tibial amputation than in those with trans-femoral amputation. BDI and BAI scores negatively correlated with erectile function, sexual desire, intercourse satisfaction, overall satisfaction and total IIEF scores. The mental and physical scores of SF-36 significantly correlated with some of the sub scores and IIEF total scores. The power of statistical analysis for study population was 100% according to the given effect size (alpha = 0.01). CONCLUSION: The present study suggests that the LLA leads to impairments in the sexual function and quality of life in male patients. Also, sexual dysfunction in patients is strongly associated with emotional state, pain, level of amputation and quality of life.
Assessment of the presence of carpal tunnel syndrome in patients with diabetes mellitus, hypothyroidism and acromegaly
(Journal of Clinical and Diagnostic Research, 2015) Oktayoğlu, Pelin; Nas, Kemal; Kılınç, Faruk; Taşdemir, Nebahat; Bozkurt, Mehtap; Yıldız, İsmail
ABSTRACT Introduction: Carpal tunnel syndrome (CTS) is one of the most common entrapment neuropathies of the upper limbs. It results from compromised median nerve function of the wrist that is caused by increased pressure in the carpal tunnel. Repetitive use of the hand and wrist, obesity, pregnancy, rheumatoid diseases, trauma and endocrinopathies are some of the risk factors for CTS. Aim: The purpose of this study was to find out whether patients with diabetes mellitus (DM), hypothyroidism and acromegaly have an increased incidence of carpal tunnel syndrome compared to each other and normal population. Materials and Methods: Patients were assigned into three groups as follows: patients with type II DM n: 100, patients with hypothyroidism n:48 and patients with acromegaly n:36. In addition, 50 healthy individuals were included in the study as control subjects. Patients were asked if they had any pain, symptoms of paraesthesia and numbness. Patients with peripheral neuropathy were excluded from the study. Boston Symptom Severity Scale and Functional Capacity Scale were used to assess symptom severity and functional capacity. CTS was investigated by performing electrophysiological study for both hands. Results: The incidence of CTS was significantly higher in all three groups compared to the control group (p>0.05). In addition, the incidence of CTS was significantly higher in the DM group compared to the hypothyroid and acromegaly groups (p<0.001). The incidence of bilateral CTS in the DM group was significantly higher compared to both hypothyroid and acromegaly groups and the control group (p<0.001). Conclusion: CTS has a higher incidence in DM, hypothyroid and acromegaly patients compared to healthy individuals. Clinicians should be careful about development of CTS in DM, hypothyroidism and acromegaly. They should adopt a multidisciplinary approach and co-operate with the psychiatrist.
Association Between Neuropathic Pain, Pregabalin Treatment, and Erectile Dysfunction
(Wiley-Blackwell, 2014) Bozkurt, Mehtap; Gocmez, Cuneyt; Soylemez, Haluk; Daggulli, Mansur; Em, Serda; Yildiz, Mehmet; Atar, Murat
Introduction. The pathophysiology of erectile dysfunction (ED) may be vasculogenic, hormonal, anatomical, neurogenic, drug-induced and/or psychogenic in origin. Neuropathic pain (NP) may facilitate ED, because it is frequently associated with anxiety, depression, and its drug, pregabalin, may also contribute ED. Aim. The objective of this study was to determine whether pregabalin treatment for patients with neuropathic pain promotes erectile dysfunction. Methods. The study sample consisted of a total of 102 male subjects that were subdivided into three groups. Group 1 patients (n = 31) had a pre-existing diagnosis of NP and was treated with 300 mg/day of pregabalin for at least 3 months. Group 2 patients (n = 34) were diagnosed with NP for at least 3 months; however, neither were they treated with pregabalin nor did they received physical therapy throughout the study. Lastly, healthy age-matched control subjects comprised group 3 (n = 37). Main Outcome Measures. Patients in all groups completed the International Index for Erectile Function (IIEF) questionnaire. Results. Mean age and mean body mass index did not differ significantly between each of the three groups. The cause of NP and the mean duration of having a diagnosis of NP did not differ significantly in groups 1 and 2. However, IIEF scores were significantly lower for group 1 when compared to group 2 in terms of erectile function, orgasmic function, overall satisfaction and total score. Yet groups 1 and 2 did not diverge significantly in the intercourse satisfaction and sexual desire scores. Overall IIEF scores for group 3 were significantly higher than those of group 2 except for mean erectile function scores. Conclusion. Taking pregabalin for the treatment of neuropathic pain poses an increased risk for developing ED in male patients. Thus, clinicians prescribing pregabalin to patients diagnosed with neuropathic pain should assess for ED before and during treatment with this medication.
Atypical cutaneous features in adult onset Still's disease
(Wolters Kluwer Medknow Publications, 2014) Akkurt, Zeynep Meltem; Bozkurt, Mehtap; Ucmak, Derya; Turkcu, Gul; Ucak, Haydar
Adult onset Still's disease is a rare but potentially serious disease. We present five cases of adult-onset Still's disease seen by us over a period of one year. The patients were all females and 28-39 years of age. Symptoms had been present for 2-6 weeks in three patients. The other two had been on a few years' follow-up for rheumatoid arthritis before the onset of rashes and fever. The patients had persistent erythematous maculopapular eruptions on face, body and extremities, with moderate to severe pruritus and/or a burning sensation that decreased their quality of life. The typical evanescent rash was not observed. High ferritin values were detected in all the patients and total serum IgE was increased in two. All the patients were started on oral prednisolone (0.5-1.0 mg/kg/day), and methotrexate (10-15 mg/week) had to be added in three patients. One patient was started on tocilizumab due to recalcitrant disease and one was lost to follow-up. Further investigation and classification of the various atypical cutaneous findings in adult-onset Still's disease is necessary.
Benign eklem hipermobilite sendromlu hastalarda emosyonel durum ve ilişkili faktörler
(Dicle Üniversitesi Tıp Fakültesi, 2014) Em, Serda; Çağlayan, Mehmet; Oktayoğlu, Pelin; Bozkurt, Mehtap; Ceylan, Veysi; Nas, Kemal
Amaç: Benign eklem hipermobilite sendromlu (BEHS) hastalarda emosyonel durumu değerlendirmek ve emosyonel durum üzerine etkili hastalıkla ilgili faktörleri belirlemektir. Yöntemler: Beighton tanı kriterlerine göre BEHS tanısı konan 63 kadın hasta ve 60 sağlıklı kontrol bu çalışmaya dahil edildi. Hastalar sorgulandıktan sonra kas-iskelet sistem muayeneleri yapılarak elde edilen bulgular kaydedildi. Hastaların kronik ağrılarını değerlendirmek için Vizüel Analog skala (VAS) kullanıldı. BEHS’li hastalar ve kontrollerin anksiyete ve depresyon durumları Hastane Anksiyete ve Depresyon Ölçeği (HADÖ) ile değerlendirildi. Bulgular: Hasta ve kontrol grubu, yaş ortalaması bakımından benzerdi. Hastaların Beighton toplam skor ortalaması (6.64 ± 1.28) kontrol grubundan (0.65±0.86) anlamlı olarak yüksekti (p<0.001). Ortalama anksiyete ve depresyon oranları açısından hasta ve kontroller arasındaki fark anlamlıydı (sırasıyla, p<0.05; p<0.01). HADÖ anksiyete skoru, hem Beighton skoru ile hem de VAS ağrı skoru ile korele iken, depresyon skoru sadece VAS ağrı skoru ile ilişkiliydi. Sonuç: BEHS’li hastalarda, sağlıklı kontrollere göre anksiyete ve depresyon oranı anlamlı derecede yüksekti. Aynı zamanda hastalardaki hipermobilite derecesi ve ağrı şiddeti ile emosyonel durum arasında bir ilişki vardı. Bu nedenle BEHS’li hastaların takip ve tedavisinde emosyonel durum göz önüne alınmalıdır
Caffeic Acid Phenethyl Ester Protects Kidneys against Acetylsalicylic Acid Toxicity in Rats
(Taylor & Francis Ltd, 2012) Bozkurt, Yasar; Bozkurt, Mehtap; Turkcu, Gul; Sancaktutar, Ahmet Ali; Soylemez, Haluk; Penbegül, Necmettin; Atar, Murat
Aim: The aim of this study was to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on acetylsalicylic acid (ASA)-induced renal damage in rats. Materials and methods: A total of 40 rats were randomly divided into five groups, with eight rats in each group-group 1: control, not receiving any medication; group 2: ASA (50 mg/kg/day); group 3: ASA (50 mg/kg/day) + CAPE (20 mu g/kg/day); group 4: ASA (100 mg/kg/day); and group 5: ASA (100 mg/kg/day) + CAPE (20 mu g/kg/day). ASA and CAPE were given via orogastric gavage for 5 days. The total oxidant status (TOS), total antioxidant capacity (TAC), and paraoxonase-1 (PON-1) activity of the blood samples and kidney tissues were determined. Histopathological examinations of the kidneys were performed using light microscopic methods. Results: The TOS level in the serum of rats and kidney tissues given ASA (groups 2 and 4) significantly increased, but the levels of TAC and PON-1 in these tissues significantly decreased in group 4 when compared with the control rats (p < 0.05). The levels of TAC and PON-1 in the kidney tissues increased and the levels of TOS decreased in the CAPE treatment groups (groups 3 and 5) when compared with the rats in the no CAPE treatment groups (groups 2 and 4). The PON-1, TAC, and TOS values reverted to normal levels in group 5 when compared to group 4 (p < 0.05). These results were supported by histopathological observation. Conclusion: Oxidative stress plays an important role in ASA-induced nephrotoxicity, and CAPE may protect against ASA-induced nephrotoxicity in rats.
Carvacrol and pomegranate extract in treating methotrexate-induced lung oxidative injury in rats
(International Scientific Literature Inc., 2014) Şen, Hadice Selimoǧlu; Şen, Velat; Bozkurt, Mehtap; Türkçü, Gül; Güzel, Abdulmenap; Sezgi, Cengizhan; Abakay, Özlem; Kaplan, İbrahim
Background: This study was designed to evaluate the effects of carvacrol (CRV) and pomegranate extract (PE) on methotrexate (MTX)-induced lung injury in rats.Material/Methods: A total of 32 male rats were subdivided into 4 groups: control (group I), MTX treated (group II), MTX+CRV treated (group III), and MTX+PE treated (group IV). A single dose of 73 mg/kg CRV was administered intraperitoneally to rats in group III on Day 1 of the investigation. To group IV, a dose of 225 mg/kg of PE was administered via orogastric gavage once daily over 7 days. A single dose of 20 mg/kg of MTX was given intraperitoneally to groups II, III, and IV on Day2. The total duration of experiment was 8 days. Malondialdehyde (MDA), total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) were measured from rat lung tissues and cardiac blood samples.Results: Serum and lung specimen analyses demonstrated that MDA, TOS, and OSI levels were significantly greater in group II relative to controls. Conversely, the TAC level was significantly reduced in group II when compared to the control group. Pre-administering either CRV or PE was associated with decreased MDA, TOS, and OSI levels and increased TAC levels compared to rats treated with MTX alone. Histopathological examination revealed that lung injury was less severe in group III and IV relative to group II.Conclusions: MTX treatment results in rat lung oxidative damage that is partially counteracted by pretreatment with either CRV or PE.
Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats
(Canadian Soc Clinical Investigation, 2014) Bozkurt, Mehtap; Em, Serda; Oktayoglu, Pelin; Turkcu, Gul; Yuksel, Hatice; Sariyildiz, Mustafa A.; Caglayan, Mehmet
Purpose: The purpose of this study was to investigate the effect of carvacrol (CAR) on methotrexate (MTX)-induced renal damage in rats. Methods: Twenty-four male rats were equally divided into three groups: group I, control treatment; group II, MTX-treated; and group III, MTX+CAR-treated. A single dose of CAR (73 mg/kg) was administered intraperitoneally to group III on the first day of the experiment and a single dose of MTX (20 mg/kg) was administered intraperitoneally to groups II and III on the second day of the experiment. Blood samples and kidney tissue were obtained from each animal on day 8 for the measurement of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Light microscopy was used for histopathological examination of kidney specimens. Results: MDA, TOS and OSI levels were significantly greater in the group receiving MTX alone relative to the control animals, while the TAS level was significantly reduced in the MTX group compared with the control group. The administration of CAR was associated with signicantly decreased MDA, TOS, and OSI levels and increased TAS levels relative to the rats treated with MTX alone. Animals treated with CAR exhibited decreased tubular degeneration and architectural impairment relative to animals treated with MTX alone; however, the difference in histological scores did not meet the threshold of statistical significance. Conclusions: MTX treatment results in oxidative damage to the rat kidney; damage which is partially abrogated by the administration of CAR.
Comparison of the Efficacy of Phonophoresis and Conventional Ultrasound Therapy in Patients with Primary Knee Osteoarthritis
(Erciyes Univ Sch Medicine, 2014) Oktayoglu, Pelin; Gur, Ali; Yardimeden, Ibrahim; Caglayan, Mehmet; Cevik, Figen; Bozkurt, Mehtap; Em, Serda
Objective: To compare the efficacy of phonophoresis (PH) versus ultrasound (US) in patients with primary knee osteoarthritis (OA). Materials and Methods: Forty patients were divided into two groups as PH and US. Acoustic gel containing no pharmacological agent was applied in the US group, whereas a gel containing 1.16% diclofenac diethylamonium was applied in the PH group for 10 sessions. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale and Visual Analogue Scale (VAS) were used for the assessment of pain. The WOMAC physical function subscale, Lequesne functional index and Stanford Health Assessment Questionnaire (HAQ) were used for the assessment of physical activities. Patients were assessed for a 3 month follow-up period. Results: In the PH group, painless walking duration improved at all follow-up times except for week 2 (p< 0.05). Painless walking distance and VAS scores also improved at all follow-up times (p< 0.05). In the US group, VAS scores during walking and flexion of the knee, WOMAC pain and physical function scores and total WOMAC scores improved significantly at all follow-up times (p< 0.05). Conclusion: Both therapeutic modalities were found effective. We suggest neither therapy is superior to the other but PH can improve painless walking duration more successfully than US.
Depressive and Anxious Temperaments in Patients with Complex Regional Pain Syndrome Secondary to Tendon Injury
(Taylor & Francis Ltd, 2014) Batmaz, Ibrahim; Dilek, Banu; Sariyildiz, Mustafa Akif; Erbatur, Serkan; Bez, Yasin; Yazmalar, Levent; Bozkurt, Mehtap
Objective: To determine the affective temperaments and somatoform amplification of the symptoms and its relation with the complex regional pain syndrome [CRPS] in patients who had tendon injuries of the forearm and hand. Methods: Sixty-seven patients [60 males, 7 females] with a forearm or hand tendon injury were enrolled in the present study. The patients were divided into two groups: CRPS and non-CRPS. The patients' pain levels within the last 48 hours were assessed using the visual analog scale [VAS]. The temperament of the patients was evaluated using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Auto questionnaire [TEMPS-A]. Their anxiety levels were evaluated with the help of the State-Trait Anxiety Inventory [STAI]. The depression assessment was performed using the Beck Depression Inventory [BDI]. The Somato sensory Amplification Scale [SSAS] was employed for the evaluation of the somatoform disorders. Results: The mean age of the patients was 26.21 +/- 8.01 years [age range: 18 to 57 years]. Among the patients 24 [35.8%] had developed CRPS. When the patients with and without CRPS were compared in terms of their psychological scores, the STAI-II and BDI scores were observed to be significantly deteriorated in the CRPS group in comparison to the non-CRPS group [p<0.05]. Among the TEMPS-A subtypes, anxious [16.7%] and depressive [41.7%] temperaments were more dominant in the CRPS group and the ratio was significantly more deteriorated than the non-CRPS group [p<0.05]. No significant difference was observed between the groups regarding the SSAS scores [p>0.05]. Conclusion: The present study is the first one evaluating the affective temperaments of CRPS patients with tendon injury, and the main findings point out that depressive and anxious temperaments are the most common dominant affective temperaments among our patients.
Determining quality of life and associated factors in patients with stroke
(Turkish Society of Physical Medicine and Rehabilitation, 2015) Em, Serda; Bozkurt, Mehtap; Karakoç, Mehmet; Çağlayan, Mehmet; Akdeniz, Dicle; Oktayoğlu, Pelin; Varol, Sefer; Nas, Kemal
Objective: This study aims to examine the overall and domain-specific quality of life in patients with stroke and to identify variables predicting quality of life after stroke. Material and Methods: A total of 104 patients with sufficient cognitive functions having hemiplegia because of cerebrovascular accident and 108 controls were included in this study. Demographic and clinical features were recorded. The Barthel Index (BI) and Functional Ambulation Category scale were employed to assess the functional state of patients. Quality of life was evaluated by the Short Form 36 (SF-36) health survey, whereas the emotional state of the patients was evaluated by the Hospital Anxiety and Depression Scale (HADS). Functional status, motor impairment, and emotional state were determined as independent variables, and multiple regression analysis was used to predict quality of life. Results: Patients had significantly lower scores in the quality of life subscores and total scores in comparison with the controls (p<0.001). The mean anxiety and depression rates in the patients were significantly higher than those in controls (p<0.001). The sum of subscores and physical composite score of SF-36 were significantly lower in female and illiterate patients than in male and educated patients. Multiple regression analyses indicated that HADS depression was associated with mental health (p<0.001), whereas BI was independently associated with the physical health total score (p<0.05). The power of the statistical analysis for study population was 100% according to the given effect size (α=0.01). Conclusion: Present results demonstrated that patients with stroke have a significantly poor quality of life than the general population. The reduced quality of life after stroke appears to be related the emotional state, physical disability, and demographic properties such as gender and education. Therefore, prevention of disability and early diagnosis and treatment of depression are vital in improving the quality of life of patients with stroke.
Diz osteoartritli hastalarda uyku kalitesinin ağrı, radyolojik hasar, fonksiyonel durum ve depresif semptomlar ile ilişkisi
(Modestum Publishing Ltd., 2013) Sarıyıldız, Mustafa Akif; Batmaz, İbrahim; Kaya, Mehmet Cemal; Bozkurt, Mehtap; Okçu, Mehmet; Yıldız, Mehmet; Yazmalar, Levent; Çelepkolu, Tahsin
Amaç: Bu çalışmanın amacı diz osteoartriti (OA) tanılı hastalarda uyku kalitesini değerlendirmek ve uyku kalitesi ile klinik parametreler, ağrı, fonksiyonel durum, radyolojik hasar ve psikolojik durum arasındaki ilişkiyi incelemektir. Yöntemler: Diz osteoartriti tanılı 52 hasta ve 35 sağlıklı gönüllü çalışmaya dahil edildi. Hastaların yaş, eğitim seviyesi, medeni durumu gibi demografik özellikleri kaydedildi. Hastalıkla ilişkili yeti yitimi, Western Ontario ve McMaster Üniversitesi Osteoartrit indeksi (WOMAC) ile değerlendirildi. Genel ağrı, genel yorgunluk ve diz ağrısı seviyesi görsel analog skala ile değerlendirildi. Psikolojik durum hastane anksiyete depresyon skalası ile ölçüldü. Diz osteoartritinin radyolojik evresi Kellgren Lawrence skoruna göre hesaplandı. Hasta ve kontrol grubunun uyku kalitesi, Pittsburgh uyku kalitesi indeksi (PUKİ) yardımıyla değerlendirildi. Bulgular: Diz osteoartriti olan hastalarda, öznel uyku kalitesi, uykuya dalma süresi, alışılmış uyku etkinliği ve total PUKİ skoru kontrol grubuna göre anlamlı olarak yüksekti (p<0,05). Spearman analizi sonuçlarına göre, total PUKİ skoru ile yaş, yaygın ağrı, diz ağrısı, WOMAC ağrı, radyolojik evre ve depresif semptomlar arasında anlamlı korelasyonlar saptandı (p<0,05). Sonuç: Diz OA tanılı hastalarda uyku kalitesi bozulmaktadır. Bozulmuş uyku kalitesi özellikle diz ağrısı, yaş, depresif semptomlar ve radyolojik evre ile ilişkilidir.
Effects of lumbosacral angles on development of low back pain
(Journal Of Musculoskeletal Pain, 2014) Çağlayan, Mehmet; Tacar, Orhan; Demirant, Ayda; Oktayoğlu, Pelin; Karakoç, Mehmet; Çetin, Abdurrahman; Em, Serda; Bozkurt, Mehtap; Uçar, Demet; Nas, Kemal
Objective: Low back pain [LBP] is an important health issue due the diagnosis and treatment expenses and loss of workforce it leads to. Biomechanical changes in the vertebral column caused by changes in the lumbosacral angles [LSAs] may lead to LBP. The purpose of this study was to assess body mass index [BMI] and LSAs in patients with LBP and investigate the association between LBP, LSAs and BMI. Methods: Lumbar lordotic angle [LLA], LSA, sacro-horizontal angle [SHA] and sacral inclination angle [SIA] were measured in 117 patients with chronic LBP and 85 healthy normal controls [HNCs] by means of lumbosacral radiography. In addition, association between LSAs, BMI and LBP was investigated. Results: There were no significant differences between patients and HNCs regarding LSAs and BMI. LLA was lower in male patients with LBP compared to male HNCs without LBP [p = 0.013]. In addition, SIA [p = 0.002] and BMI [p = 0.006] were higher in female patients with LBP compared to male patients with LBP. It was found that an increase in LLA increased the risk of having LPB by approximately 1.04-folds [ranging from 1.01 to 1.08; p = 0.045]. On the other hand, no association was found between LSAs and BMI. Conclusion: Changes in LSAs may cause LBP. An increase in LLA may be influential in increasing the risk of LBP. Therefore, measurement of LSAs may guide the physician who is to make clinical decisions in examination of patients with LBP.
Elevated Serum Levels of Calprotectin (Mrp8/14) in Patients with Systemic Sclerosis
(Clinical & Exper Rheumatology, 2014) Oktayoglu, Pelin; Mete, Nuriye; Kaya, Halide; Caglayan, Mehmet; Bozkurt, Mehtap; Nas, Kemal
[Abstract Not Available]
Elevated serum levels of calprotectin (MRP8/MRP14) in patients with Behcet's disease and its association with disease activity and quality of life
(Taylor & Francis Ltd, 2015) Oktayoglu, Pelin; Mete, Nuriye; Caglayan, Mehmet; Bozkurt, Mehtap; Bozan, Turgut; Em, Serda; Nas, Kemal
Background. Behcet's disease (BD) is an inflammatory disease with multisystem chronic vasculitis. The disease is characterized by attacks of oral and genital ulcerations, skin lesions, arthritis, uveitis and deep vein thrombosis. The main histopathological feature is known to be vascular inflammatory change. Calprotectin (MRP8/MRP14) has been identified as an important alarmin that is expressed by activated phagocytes, granulocytes, monocytes and vascular endothelial cells, recognized by toll-like receptors, and induces a thrombogenic and inflammatory response in human microvascular endothelial cells. Aim. We aimed to investigate the serum levels of calprotectin in patients with BD and its association with disease activity and quality of life. Materials and methods. Forty-eight patients (25 males and 23 females) and 47 healthy controls (29 males and 18 females) were included to study. BD Current Activity Form (BDCAF) was used to assess the disease activity of patients with BD. Quality of life was assessed by using the Nottingham Health Profile (NHP). Depression and anxiety symptoms were assessed by using the Hospital Anxiety and Depression Scale (HADS). Serum level of calprotectin was determined using an ELISA kit. Results. Serum levels of calprotectin was significantly higher in patients with BD compared to healthy controls (p = 0.001). Serum levels of calprotectin did not correlate with the sores of BDCAF, NHP and HADS. Conclusion. Calprotectin may play a significant role in the pathogenetic mechanisms of BD. Further insight into this area of research might provide opportunities to develop novel treatment strategies.
Elevated Serum Levels of Calprotectin (Myeloid-Related Protein 8/14) in Patients With Ankylosing Spondylitis and Its Association With Disease Activity and Quality of Life
(Lippincott Williams & Wilkins, 2014) Oktayoglu, Pelin; Bozkurt, Mehtap; Mete, Nuriye; Caglayan, Mehmet; Em, Serda; Nas, Kemal
Background: Calprotectin is one of the major leukocyte S100 proteins showing both calcium binding and antimicrobial characteristics. The serum level of calprotectin is markedly elevated in patients with inflammatory bowel disease, rheumatoid arthritis, as well as systemic lupus erythematosus and has been suggested to play a prominent role in both progression and pathogenesis of these diseases. Aim: The purpose of this study was to investigate the serum level of calprotectin in patients with ankylosing spondylitis (AS) and its association with disease activity and other clinical characteristics of AS. Materials and Methods: Thirty-one patients who met the modified New York criteria for AS and 45 healthy controls were included in this study. Both Bath AS disease activity index and AS disease activity score were applied on the patients with AS for the assessment of disease activity; Bath AS functional index, for the assessment of functional activity; Bath AS radiology index, for the assessment of radiological damage; and the AS quality of life questionnaire for the assessment of disease-related life status. Spinal and hip measurements were performed using Bath AS metrology index. The serum level of calprotectin was determined using enzyme-linked immunosorbent assay kit. Results: Mean serum level of calprotectin was significantly higher in the patients with AS compared with healthy controls (P = 0.003). Serum levels of calprotectin did not correlate with Bath AS disease activity index, AS disease activity score, Bath AS functional index, Bath AS radiology index, Bath AS metrology index, modified Schober, chest expansion, AS quality of life questionnaire, erythrocyte sedimentation rate, and C-reactive protein values (P > 0.05). Conclusions: Our results suggest that calprotectin might play an important role in the pathogenetic mechanisms of AS; however, the calprotectin levels did not correlate with the measurements of disease activity, functional abilities, radiological damage, and the quality of life in these patients. Further insight into this area of research might provide opportunities to develop novel treatment strategies, which take into account the role of these peptides in the pathogenetic mechanisms of AS.

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