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Öğe Ağır doğumsal pitozlu olguların onarımında superior tabanlı fleple (frontal kas ilerletme) frontal askı yönteminin değerlendirilmesinde (otojen fasya ile) klinik yaklaşımımız(2006) Külahçı, Yalçın; Bozkurt, Mehmet; Benlier, ErolBlefaroptoz birçok değişik nedene bağlı olarak gelişen ve farklı şiddette kendini gösteren üst göz kapağının anormal düşüklüğüdür. Bugüne kadar birçok cerrahi onarım tekniği tanımlanmıştır. Cerrahi girişiminde ana belirleyici etken ptozis derecesi ve kapak işlevinin miktarıdır. Ağır ptozlarda frontial askı yöntemi birçok cerrahlar tarafından kabul gören cerrahi yöntemdir. Yine aynı şekilde frontal kas ilerletme ağır kongenital ptozlarda başarıyla kullanılmaktadır. Bu klinik çalışmamızda, ağır kongenital ptozu olan 15 olgumuzun (13'ü ekek 2'si bayan ortlama yaş 25+1.2 ) sonuçlarını superior tabanlı flep (frontal kas ilerletme) ve üç bantlı frontal askı yöntemi (tribant fiksasyonu) kullanılarak her iki tekniğin avantaj ve dezavantajları tartışılmaktadırÖğe An Alternative Approach to Avoiding the Whistling Deformity After Cleft Lip Surgery: Dermal Flap and Irregular Z-Plasty(Lippincott Williams & Wilkins, 2010) Bozkurt, Mehmet; Kapi, Emin; Kuvat, Samet VasfiThe whistling deformity is characterized by tissue loss in the medial tubercle of the lips after cleft lip repair. Vermilion deficits can be treated by performing upper-lip flaps, Z-plasties, V-Y plasty techniques, and tongue flaps or grafts. However, the debate continues as to which of these is the most effective procedure. In this study, the combination of dermal flap derived from lateral mucosal flap and irregular Z-plasty repair is proposed as an alternative approach for the repair of vermilion deformities. Fourteen patients who presented to our clinic with cleft lip deformities between April 2008 and December 2009 underwent modified Millard repair, Mohler repair, or Mulliken method to successfully treat 9, 3, and 2 patients, respectively. At the end of the study, it was observed that all cases resulted in a favorable postoperative cosmetic appearance. Consequently, we believe that this technique is an alternative approach that could be applied to cleft lip patients with vermilion deformity.Öğe An Alternative Flap Choice in Penis Skin Defects: Preputial Mucosal Flap(Elsevier Science Inc, 2009) Bozkurt, Mehmet; Zor, Fatih; Kulahci, Yalcin; Kapi, Emin; Karakol, PercinIn this study, the authors present their experience with preputial mucosal flap usage for reconstruction of full-thickness skin loss of the penis in a patient with scald injury and discuss the possible treatment modalities in penile skin defects. During the 2-year follow-up period, no complication was encountered, and the patient healed uneventfully. UROLOGY 74: 1344-1346, 2009. (C) 2009 Published by Elsevier Inc.Öğe An Alternative Frontalis Suspension Technique Triband Suspension-A Modified Garcia's Procedure(Lippincott Williams & Wilkins, 2011) Benlier, Erol; Bozkurt, Mehmet; Kulahci, Yalcin; Kapi, Emin; Sahin, CihanBlepharoptosis surgery is one of the most common oculoplastic procedures, and the aim is to clear the visual axis. Many surgical techniques for the correction of ptosis have been described and performed, but the operative approach is based on the extent of eyelid excursion, the amount of levator function, and the degree of ptosis. In this study, the frontalis sling procedure with triband suspension was performed on 32 eyelids of 23 patients. All the patients had visual loss because of blepharoptosis with only 0 to 3 mm of measurable levator function. Postoperatively, the palpebral fissure was increased in all the patients. The purpose of this study was to report the use of a modified frontalis sling procedure for congenital ptosis patients with minimal to no levator function. In conclusion, this modified frontalis sling technique if used maximizes the frontalis muscle, creating sufficient eyelid elevation, with stable effect over time.Öğe An alternative procedure for conjunctivodacryocystorhinostomy - Supratrochlear artery-based island flap combined with buccal mucosal graft(Lippincott Williams & Wilkins, 2008) Benlier, Erol; Bozkurt, Mehmet; Kulahci, YalcinReconstruction of the total canalicular obstruction with destroyed medial canthal area is a challenging procedure for ophthalmic, plastic, and reconstructive surgeons. In the case presented, a supratrochlear artery-based island flap combined with a buccal mucosal graft was used for reconstruction of the medial canthal area. The medial canthal area was scarred significantly and demonstrated a medial ectropion and complete canalicular obstruction. To our knowledge, it is the first time for combined reconstruction of the medial canthal area and lacrimal drainage system in 1 stage, with island median forehead flap based on supratrochlear artery and buccal mucosal graft. During the 2-year follow-up period, no complication was encountered and the patient healed uneventfully.Öğe ALTI YAŞINDAKİ BİR OLGUDA AKUT MARJOLİN ÜLSERİ(Türk Plastik Rekonstrüktif ve Estetik Cerrahi Derneği, 2010) Bozkurt, Mehmet; Kuvat, Samet Vasfi; Baykan, Halit; Kapı, Emin; Özekinci, SelverMarjolin ülseri, yanık ya da posttravmatik skar alanlarından gelişen, yayılım oranı yüksek, sık tekrarlama eğilimi gösteren, tedavisi bu nedenle zorluk teşkil eden ölümcül ve kötü huylu bir tümördür. Kronik yaralardan sonra malign dönüşüm gözlenmesi sıklıkla orta ve ileri yaşlarda ortaya çıkar. Pediatrik yaşta ortaya çıkan akut Marjolin ülserleri ise çok nadir gözlenir. Bu çalışmada 6 yaşındaki erkek olguda, alt ekstremitede ülsere ve iyileşmeyen lezyon nedeniyle uygulanan cerrahi tedavi ve elde edilen bulgular sunulmaktadır. Olgunun anamnezinden lezyonun sekonder iyileşmeye bırakıldığı, travma sonrası 1 yıl içinde hiperplazi geliştiği öğrenildi. Cerrahi rezeksiyon sonrasında lezyon histopatolojik olarak skuamöz hücreli hiperplazi tanısı aldı. Operasyon sonrası 1. yılda nüks gözlenmedi. Literatürde Marjolin ülserlerinde sıklıkla yassı hücreli karsinom tanıları elde edilmekte ise de, farklı histopatolojik tanılarla da karşılaşılabilmektedir. Olgumuz, pediatrik yaşta olmasına rağmen kısa bir latent periyoda sahip olması nedeniyle oldukça ilgi çekicidir.Öğe Antioxidant support in composite musculo-adipose-fasciocutaneous flap applications: An experimental study(Taylor & Francis Ltd, 2014) Bozkurt, Mehmet; Kapi, Emin; Kulahci, Yalcin; Gedik, Ercan; Ozekinci, Selver; Isik, Fatma Birgul; Celik, YusufFree radicals are chemicals that play roles in the etio-pathogenesis of ischaemia-reperfusion injury. Various antioxidants have been used in an attempt to mitigate the damage induced by these chemicals. In the present study, the antioxidative effects of grape seed extract (proanthocyanidin), tomato extract (lycopene), and vitamin C (ascorbic acid) on a composite re-established-flow inferior epigastric artery based rectus abdominis muscle-skin flap model on which experimental ischaemia was induced were investigated. The rats have been administered antioxidants for 2 weeks prior to the surgery and for 2 more weeks thereafter. Macroscopic, histopathological, and biochemical analyses were carried out at the decision of the experiment. It was found that flap skin island necrosis was significantly reduced in the proanthocyanidin, lycopene, vitamin C groups (p < 0.001). Statistical analyses showed significant decreases in inflammation, oedema, congestion, and granulation tissue in the proanthocyanidin and lycopene groups compared to the vitamin C and control groups (p < 0.001). When the viability rates of fat and muscle tissues were examined, significant improvements were found in the proanthocyanidin and lycopene groups in comparison to the other groups (p < 0.001). Serum antioxidant capacity measurements revealed significant differences in the lycopene group compared to all other groups (p < 0.001). It is concluded that lycopene and proanthocyanidin are protective antioxidants in rat composite muscle-skin flap ischaemia-reperfusion models.Öğe The association between cellular morphological changes in peripheral blood smear and complications in pediatric burn cases(Turkish Assoc Trauma Emergency Surgery, 2011) Bozkurt, Mehmet; Kuvat, Samet Vasfi; Kapi, Emin; Karakol, Percin; Ozel, Abdulkadir; Baykan, HalitBACKGROUND Mortality and morbidity in burn cases can be reduced with early diagnosis. Many markers are used for early diagnosis of burn complications like sepsis. In this current study, the relationship between numerical/morphologic granulocyte abnormalities and complications was investigated in pediatric burns. It was aimed to introduce histopathologic marker(s) for burn-related complications. METHODS Thirty-two pediatric burn cases hospitalized between December 2006 and December 2009 were included in the study. A total of 192 complete blood count and peripheral blood smear results were analyzed comparatively. Findings were used to identify any correlation among white blood cell count and peripheral blood smear changes (the appearance of immature granular cells, toxic granulation, purple granules and Dohle bodies) and complications such as bacteriemia, sepsis, wound infections, severe anemia, and graft failure. RESULTS White blood cell count changes and the appearance of immature granular cells were not suitable for use as a diagnostic marker for complications. Nevertheless, there was a statistically significant correlation between the appearance of toxic granulation, purple granules and Dohle bodies and subsequent complications (p: < 0.0001, 0.041, 0.001, respectively). CONCLUSION Toxic granulation, purple granules and Dohle bodies appear to be helpful in predicting burn-related complications. Therefore, peripheral blood smear is a suitable test for predicting future complications.Öğe Birinci basamak yanık tedavisinde altın standartlar(Dicle Üniversitesi Tıp Fakültesi, 2009) Zor, Fatih; Ersöz, Nail; Külahçı, Yalçın; Kapı, Emin; Bozkurt, MehmetDünyada her yıl 2.5 milyon insan yanıktan etkilenmektedir. Ülkemizde bu konuyla ilgili kesin bir veri tabanı bulunmamaktadır. Ancak son zamanlarda Türkiye’de yanık epidemiyolojisi ile ilgili sağlıklı istatistiksel veriler elde edilmeye çalışılmaktadır. Yanık yaralanması sonrasında miyokard infarktüsü, kalp yetmezliği, akut hipertansiyon, endokardit, tromboemboli, pulmoner ödem, pnömoni, solunum yetmezliği, böbrek yetmezliği, gastrik ülser, ileus, sepsis, koagülopati, anemi gibi çok çeşitli komplikasyonlar gözlenebilir. Bazı komplikasyonlar önlenebilir ya da tedavi edilebilir özelliktedir. Bu nedenle yanık olgularında ilk basamak tedavide alınacak tedbirlerin önemi oldukça büyüktür. Deri, vücut yüzeyinde oluşan fark edilmeyen sıvı kaybını önleyen bir bariyerdir. Akut yanıklı olgularda, deri yüzeyi kaybına bağlı olarak ısı kaybı ortaya çıkar. Bu olgularda, vücut sıcaklığının korunmasına yönelik girişimler önem taşır. Ayrıca sıvı resusitasyonu oldukça önemlidir. Yanıklı olgularda bir diğer özellik, akut dönemde hasarlı dokuların enfeksiyona oldukça yatkın olmasıdır. Yanık bakımı ve tedavisi, oldukça zor ve kompleks prosedürler içerir. Bu bakımdan, yanık olgularının tedavisi titiz ve multidisipliner yaklaşımlar gerektirmektedir.Öğe Bolster Implementation of Custom-Made Plaster in the Reconstruction of Cleft Lip Nose(Lippincott Williams & Wilkins, 2011) Kapi, Emin; Bozkurt, Mehmet; Kuvat, Samet Vasfi[Abstract Not Available]Öğe Burn Injuries Related to Liquefied Petroleum Gas-Powered Cars(Lippincott Williams & Wilkins, 2008) Bozkurt, Mehmet; Kulahci, Yalcin; Zor, Fatih; Kapi, EminLiquefied petroleum gas (LPG), which is used as a type of fuel, is stored as a liquid under high pressure in tanks. Immediate and sudden explosion of these tanks can release a large amount of gas and energy into the environment and can result in serious burns. In this study, the cases of 18 patients injured due to LPG burns in five incidents were examined, along with their epidemiologic features. The authors also investigated the causes of the LPG tank explosions. Inhalation injury was present in 11 cases with varying degrees of severity, and 7 patients subsequently required mechanical ventilation. The explosions resulted from weakening of the tank wall (n = 2), crash impact (n = 2), and gas leakage from the tank (n = 1). LPG-powered cars are becoming more popular because of their lower operational costs. However, LPG tanks can be hazardous in the event of a tank explosion. Burns caused by explosions of the LPG tanks in cars have significant mortality and morbidity. This danger must be taken into account and public awareness must be increased. (J Burn Care Res 2008;29:897-901)Öğe Cartilage-Supported Paramedian Forehead Flaps for Reconstruction of Full-Thickness Nasal Defects(Lippincott Williams & Wilkins, 2013) Selcuk, Caferi Tayyar; Durgun, Mustafa; Ozalp, Burhan; Bozkurt, MehmetThe nose is an important esthetic structure of the human face, and its defects may lead to serious esthetic and functional losses. In the current study, our aim was to present the results of the repairs that we performed using cartilage-supported forehead flaps in patients with full-thickness nasal defects in various locations. Between March 2009 and March 2012, a total of 6 patients with full-thickness nasal defects underwent repairs using cartilage-supported forehead flaps. Among the patients, 4 were women, whereas 2 were male. The median age of the patients was 60.3 (38-67) years. The defects were caused by either tumor excision or burn wounds. Defect areas were at the dorsum of the nose, the medial canthal area, and the distal half of the nose. The repairs in all patients were performed using cartilage-supported median forehead flaps. In the method we applied, to provide framework support, a cartilage graft was placed into the pouch formed between the frontal muscle and the subcutaneous tissue within the flaps to be adapted to the defect area. The patients were followed up for a median period of 11 (4-27) months. In the long-term follow-up of all patients, satisfactory results in terms of the functional and cosmetic outcomes were obtained. Through the technique we applied, a simple and safe repair with adequate framework support and full color and texture harmony is achieved.Öğe Combined superior crescentic total glandular augmentation mastopexy: report of 37 cases(Springer, 2012) Guven, Erdem; Sakinsel, Ali; Basaran, Karaca; Yazar, Memet; Bozkurt, Mehmet; Kuvat, Samet Vasfiof periareolar, donut, or crescentic patterns for augmentation mastopexy in mild to moderate ptosis cases are minimally invasive (short scar) options. In this article, we report a modified version of the classical crescentic technique of augmentation mastopexy, namely, superior crescentic total glandular augmentation mastopexy. Thirty-seven patients with (a) breasts having mild to moderate ptosis (Regnault grades I-II), (b) breasts requiring less than 3 cm of nipple-areola elevation, and (c) mild skin elasticity were included in the study. During surgery, the mean size of 290 cc of silicon gel-filled implants were placed. The mean follow-up was 39 months ranging from 6 and 58 months. None of the patients had disastrous complications such as skin or nipple-areola necrosis. Poor scar healing and areolar asymmetry were the main problems encountered during follow-up. Ptosis recurrence (n= 1), and capsular contracture (n= 1) were the main reasons for revision surgery (5.4%). Five patients were re-operated on due to complications and implant change requirements (13.5%, total revisions). Mean suprasternal notch-nipple distance was recorded as 20.8 cm (19.3-22.4 cm) postoperatively. After an average time of 39 months, this distance was found to be 21.2 cm (20.1-23.2 cm) (the case with the recurrent ptosis was excluded). Superior crescentic total glandular augmentation mastopexy has yielded satisfactory results in patients with mild to moderate breast ptosis; therefore, it seems to be a valuable option in terms of minimally invasive augmentation mastopexy techniques.Öğe Comparison of Effects of Pulsed Electromagnetic Field Stimulation on Platelet-Rich Plasma and Bone Marrow Stromal Stem Cell Using Rat Zygomatic Bone Defect Model(Lippincott Williams & Wilkins, 2015) Kapi, Emin; Bozkurt, Mehmet; Selcuk, Caferi Tayyar; Celik, Mehmet Salih; Akpolat, Veysi; Isik, Fatma Birgul; Bozarslan, Beri HocaogluBackground Reconstruction of bone defects that occur because of certain reasons has an important place in plastic and reconstructive surgery. The objective of the treatments of these defects was to reinstate the continuity of tissues placed in the area in which the defect has occurred. In this experimental study, the effect of pulsed electromagnetic field stimulation on platelet-rich plasma (PRP) and bone marrow stromal cell, which propounded that they have positive impact on bone regeneration, was evaluated with the bone healing rate in the zygomatic bone defect model enwrapped with superficial temporal fascia. Methods After creating a 4-mm defect on the zygomatic bone of the experiments, the defect was encompassed with a superficial temporal fascial flap and a nonunion model was created. After surgery, different combinations of the PRP, bone marrow stromal cell, and electromagnetic field applications were implemented on the defective area. All the experiments were subjected to bone density measurement. Results The result revealed that the PRP and pulsed electromagnetic field implementation were rather a beneficial and an effective combination in terms of bone regeneration. Conclusions It was observed that the superficial temporal fascial flap used in the experiment was a good scaffold choice, providing an ideal bone regeneration area because of its autogenous, vascular, and 3-dimensional structures. As a result, it is presumed that this combination in the nonhealing bone defects is a rather useful treatment choice and can be used in a reliable way in clinical applications.Öğe A Comparison of the Effects of Epidural and Spinal Anesthesia With Ischemia-Reperfusion Injury on the Rat Transverse Rectus Abdominis Musculocutaneous Flap(Lippincott Williams & Wilkins, 2013) Acar, Yusuf; Bozkurt, Mehmet; Firat, Ugur; Selcuk, Caferi Tayyar; Kapi, Emin; Isik, Fatma Birgul; Kuvat, Samet VasfiThe purpose of this study is to compare the effects of spinal and epidural anesthesia on a rat transverse rectus abdominus myocutaneous flap ischemia-reperfusion injury model. Forty Sprague-Dawley rats were divided into 4 experimental groups: group I (n = 10), sham group; group II (n = 10), control group; group III (n = 10), epidural group; and group IV (n = 10), spinal group. After the elevation of the transverse rectus abdominus myocutaneous flaps, all groups except for the sham group were subjected to normothermic no-flow ischemia for 4 hours, followed by a reperfusion period of 2 hours. At the end of the reperfusion period, biochemical and histopathological evaluations were performed on tissue samples. Although there was no significant difference concerning the malonyldialdehyde, nitric oxide, and paraoxonase levels in the spinal and epidural groups, the total antioxidant state levels were significantly increased, and the total oxidative stress levels were significantly decreased in the epidural group in comparison to the spinal group. The pathological evaluation showed that findings related to inflammation, nuclear change rates and hyalinization were significantly higher in the spinal group compared with the epidural group. Epidural anesthesia can be considered as a more suitable method that enables a decrease in ischemia-reperfusion injuries in the muscle flaps.Öğe Comparison of the effects of inhalation, epidural, spinal, and combined anesthesia techniques on rat cremaster muscle flap microcirculation(Wiley, 2010) Bozkurt, Mehmet; Kulahçı, Yalçın; Zor, Fatih; Şen, Hüseyin; Açıkel, Cengiz Han; Deveci, Mustafa; Türegün, Murat; 0000-0002-6836-2732; 0000-0002-5851-0711; 0000-0001-5699-4305Background: This experimental study was designed to investigate and compare the effects of different anesthesia techniques on rat cremaster muscle flap microcirculation. Methods: Fifty male Sprague-Dawley rats (130-150 g body weight) were divided into five experimental groups containing ten animals each. Group I, group II, and group III were designated as inhalation, epidural, and spinal anesthesia groups, respectively. Group IV was designated as a combination group for inhalation and epidural anesthesia. Group V was a combination group of inhalation and spinal anesthesia. Results: Group III and group V showed significant increases in the number of rolling and sticking leucocytes and in RBC volume (peripheral stasis) when compared with group I. Blood flow and velocity significantly increased without peripheral stasis in groups II and IV when compared with group I. Although there was no statistically significant difference in the numbers of rolling, sticking, and transmigrating leucocytes or in functional capillary perfusion, group IV had better flow hemodynamics in the peripheral microcirculation when compared with group I. Conclusions: The inhalation and epidural anesthesia combination was determined to be the ideal anesthesia technique for improved peripheral microcirculation. Spinal anesthesia, either separately or in combination with inhalation anesthesia, has adverse effects on microcirculation.Öğe Comparison of the effects of intratubal injection of adipose-derived mesenchymal stem cells in a rat sciatic nerve transection an experimental study(Lippincott William & Wilkins, 2022) Karakol, Perçin; Kapı, Emin; Karaöz, Erdal; Tünik, Selçuk; Bozkurt, MehmetThis study was designed to evaluate the efficacy of epineural tubulization (ENT) with or without intratubal application of adipose-derived mesenchymal stem cells (ASCs) in the rat model of sciatic nerve transection. After formation of 1-cm defect in the left sciatic nerve and ENT, 32 adults female Wistar albino rats were separated into 4 groups (n = 8 for each) including ENT per se (group 1; ENT group) and ENT plus intratubal ASC injection groups killed on day 21 (group 2; ENT-ASC-21-day group), 60 days (group 3; ENT-ASC-60-day group), and 120 days (group 4; ENT-ASC-120-day group). Functional (sciatic function index, hip circumference, withdrawal reflex latency, muscle weight ratio), electrophysiological, histomorphometric, and immunohistochemical analyses were performed in each group. Sciatic function index was significantly higher (-51.98 +/- 5.94, P < 0.01) and withdrawal reflex latency was shorter (-6.21 +/- 2.14, P < 0.01), in the group 4 as compared with all other groups on day 21. Amplitude of contraction was significantly lower in the group 4 as compared with all other groups (0.22 +/- 0.05 vs 0.34 +/- 0.07, 0.50 +/- 0.11, and 0.61 +/- 0.16, P < 0.01 for each). Immunohistochemical analysis revealed presence of green fluorescent protein, vimentin-stained cells, and single neural progenitor cells indicating that induction of neuronal differentiation by ASCs and direct involvement of ASCs within the axonal structure alongside extension of ASCs to the muscular layer of the group 4. In conclusion, our findings revealed that use of ENT plus intratubal ASC injection in a rat sciatic nerve transection model was associated with satisfactory functional outcome and improved peripheral axonal regeneration along with stem cell neural differentiation.Öğe Conservative Treatment of a Patient with Epidermolysis Bullosa Presenting as Bart Syndrome: A Case Report(Hindawi Ltd, 2010) Kuvat, Samet Vasfi; Bozkurt, MehmetWe presented a case of a newborn male with aplasia cutis congenita on the lower limb. The case was treated with conservative method. As for the conservative treatment, daily hydrodebridement with 1/200 diluted povidone-iodine and serum physiologic was performed, followed by closure of the wound with a dexpanthenol + chlorhexidine + fusidic acid-impregnated sterile gauze bandage. the followup that occured after three weeks, the wound was completely epithelialized, but a hypopigmented scar remained in the limb.Öğe Current Concepts in the Management of Marjolin's Ulcers: Outcomes From a Standardized Treatment Protocol in 16 Cases(Oxford Univ Press, 2010) Bozkurt, Mehmet; Kapi, Emin; Kuvat, Samet Vasfi; Ozekinci, SelverMarjolin's ulcer is a malignant lesion observed in chronic wounds and in areas where the integrity of the skin is compromised because of any one of several reasons. The aim of this study was to define etiology, topography, and histopathology for Marjolin's ulcer and its surgical management. Sixteen cases were diagnosed and treated as Marjolin's ulcers. The mean age was 57.1 years (range, 32-85 years) and 15 of the patients (93.75%) had history of ulcer of 30 years or more. In 10 cases (62.5%), Marjolin's ulcer occurred after a flame burn and in 6 cases (37.5%) after a scalding burn injury. In six cases (37.5%), there was history of chronic trauma due to contact with the clothing. Primary lesions were at the leg, gluteal region, thigh, scalp, trunk, and hand in four (25%), three (18.7%), two (12.5%), two (12.5%), three (18.7%), and two (12.5%) cases, respectively. Amputation was carried out to treat two cases, and repair of the defects with partial-thickness skin grafting was performed in 14 cases after tumor resection on the skin. Superficial inguinal lymph node dissections were performed in four cases with tumor in the thigh and a positive inguinal lymph node. Squamous cell carcinoma was diagnosed in 14 cases (87.5%) and basal cell carcinoma in two cases (12.5%) postoperatively. The authors conclude that diagnosis and surgical planning based on the recent literature must be carried out even more intensively to improve the prognosis of Marjolin's ulcer. (J Burn Care Res 2010; 31: 776-780)Öğe Danazol kullanımının dorsal rat flebi canlılığı üzerine etkileri(Dicle Üniversitesi Tıp Fakültesi, 2009) Yücetaş, Altan; Bozkurt, Mehmet; Kapı, Emin; Kılınç, NihalVücudun dış örtü tabakası olan cildin büyük defektlerinin kapatılması, rekonstrüktif cerrahinin önemli sorunlarından biridir. Cilt defektlerinin kapatılmasında en uygun fonksiyonel ve estetik yaklaşım, fleplerin kullanılmasıdır. Büyük defektlerin kapatılmasında kullanılan fleplerin boyutları da sınırlıdır. Planlanan flebin boyu uzadıkça flep yaşayabilirliğinde azalma gözlenmektedir. Bu durum kendisini özellikle flep distalinde nekroz ve doku kaybı olarak göstermektedir. Bu sorunları giderebilmek için kan akımını arttıran sempatolitik ajanlar ve antikoagülanlar, kanın reolitik özelliğini değiştiren ajanlar kullanılmış, ayrıca iskemik hücrelerde hücre zarı stabilizasyonu sağlanmaya çalışılmıştır. Danazol, antienflamatuar etkisi bulunan, endometriozis tedavisinde kullanılan zayıf etkili bir gonadotropik hormondur. Bu ajan, dokulara olan antienflamatuar etkisini çok değişik mekanizmalarla gösterir. Bu çalışmada deney hayvanı olarak dişi, erişkin Sprague-Dawley sıçan kullanıldı. Deneysel dorsal rat flebi modelinde random paternli deri flebinin distal kısmında nekroz gelişimini azaltmak ve flebin yaşayabilirliğini arttırmak için antiinflamatuar ve antikoagülan etki mekanizmalarına sahip olabilen danazol kullanılmıştır. Bu yazıda danazolün antienflamatuar etki mekanizmasının yanında, flep canlılığına etkisi üzerine değinilmiştir.
