Yazar "Bozkurt, M." seçeneğine göre listele
Listeleniyor 1 - 16 / 16
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe ANTIOXIDANT EFFECTS OF POMEGRANATE EXTRACT AGAINST METHOTREXATE-INDUCED TESTICULAR INJURY IN RATS(Wiley-Blackwell, 2014) Bozkurt, Y.; Daggulli, M.; Bodakci, M. N.; Soylemez, H.; Bozkurt, M.; Sancaktutar, Ahmet Ali; Penbegul, N.[Abstract Not Available]Öğe Distant muscular (rectus femoris) metastasis from laryngeal squamous cell carcinoma(Cambridge Univ Press, 2009) Kulahci, Y.; Zor, F.; Onguru, O.; Bozkurt, M.; Duman, H.Objective: We report an extremely rare case of distant metastasis to the rectus femoris muscle from a laryngeal squamous cell carcinoma. Method: We present a case report and a review of the world literature concerning distant skeletal muscle metastasis from head and neck squamous cell carcinoma. Results: The patient showed no evidence of distant muscular recurrence at follow up after 21 months; however, two years later he died from brain and suprarenal metastases. Conclusion: This report describes the first case of haematogenous distant metastasis to the left rectus femoris muscle from a laryngeal squamous cell carcinoma, without evidence of cervical lymph node metastases. To the best of our knowledge, this is the second reported case of muscular distant metastasis without cervical lymph node involvement. Although the prognosis associated with skeletal muscle metastasis is considered to be poor, surgical excision may be indicated for an isolated muscular metastasis.Öğe The Effect of External Beam Irradiation Timing on Skin Graft Survival(Karger, 2010) Kulahci, Y.; Duman, H.; Zor, F.; Bozkurt, M.; Guden, M.; Gunhan, O.; Celasun, B.Background: The purpose of this study was to evaluate skin graft integrity after external beam irradiation in a rat model. Methods: Forty-eight male Wistar rats were randomly assigned to 8 groups (A, B, C, D, A(c), B-c, C-c and D-c). A rectangular full-thickness skin graft was raised and reapplied to its original bed on the dorsum of each rat. Groups A(c), B-c, C-c and D-c were the control groups and were not given postoperative irradiation. After grafting, 25 Gy unfractioned cobalt(60) irradiation was administered to groups A, B, C and D on postoperative days 10, 20, 30 and 40, respectively. Histological samples were obtained 8 weeks after grafting. Dermal and epidermal thickness were measured by the KS-400 image analysis program. Results: The difference in the epidermal and/or dermal thickness between the irradiated groups was not found to be significant. Furthermore, when histological features and the image analysis of the irradiated groups were compared with each other, there were no significant differences between the groups. Conclusions: Although we are aware that experimental results may not directly translate to the clinical setting, the present study indicates that external radiotherapy can be performed to skin-grafted areas as early as 10 days postoperatively. Copyright (C) 2010 S. Karger AG, BaselÖğe Effects of timing in the applications of radiotherapy after transverse rectus abdominis musculocutaneous flap in rats(Ijrr-Iranian Journal Radiation Res, 2022) Binicier, O.; Caskan, P. K.; Kapi, E.; Bozkurt, M.; Zincircioglu, S. B.; Kulahci, Y.; Selcuk, C. T.Background: The present study aimed to investigate flap status in relation to the timing of radiotherapy (RT) in an experimental rat model of irradiated transverse rectus abdominis musculocutaneous (TRAM) flap. Materials and Methods: Fifty-six adult male Sprague-Dawley experiments were separated in seven groups in terms of flap surgery and RT. The groups comprised sham group, control (Ctrl) group, RT group, and RT plus surgery (RT+Surg) group, which was further separated in four groups depending on the timing of postoperative RT as RT+Surg-10 (RT on postoperative 10th day), RT+Surg-20 (RT on postoperative 20th day), RT+Surg-30 (RT on postoperative 30th day), and RT+Surg-40 (RT on postoperative 40th day). All the rats were sacrificed 8 weeks after the RT administration for histopathological analysis. Results: Compared with the RT+Surg-10 and RT+Surg-20 groups, the hyalinization and collagenization scores in RT+Surg-30 were determined to be significantly lower. Fibrosis scores were lower in the RT+Surg-30 group compared with the RT+Surg-20 group, whereas significantly lower inflammation scores were determined in the RT + Surg-40 group and significantly higher dermal thickness in the RT+Surg-30 group compared with the RT+Surg-10 group. Conclusions: The findings from this model of irradiated flap revealed the significance of the time lag among flap application and postoperative RT for histopathological outcome, emphasized the potential role of at least a 30- to 40day interval between surgery and RT in achieving more favorable flap status.Öğe THE IMPACT OF ANKYLOSING SPONDYLITIS ON FEMALE SEXUAL FUNCTIONS(Wiley-Blackwell, 2014) Bozkurt, M.; Sariyildiz, M. A.; Batmaz, I; Karakoc, M.; Cevik, R.; Bozkurt, Y.; Penbegul, N.[Abstract Not Available]Öğe The impact of ankylosing spondylitis on female sexual functions(Nature Publishing Group, 2013) Sariyildiz, M. A.; Batmaz, I.; Inanir, A.; Dilek, B.; Bozkurt, M.; Bez, Y.; Karakoc, M.The aim of this study was to explore the impact of ankylosing spondylitis (AS) and the disease-related variables, psychological status and the quality of life on the female patients' sexual function measured according to the Female Sexual Function Index (FSFI). Thirty-seven sexually active female AS patients and 33 healthy controls were enroled in this study. Their demographic data were evaluated and the generalised pain in patients with AS was assessed according to the visual analogue scale (0-100 mm). Laboratory tests were conducted in order to measure the C-reactive protein (CRP) and erythrocyte sedimentation rates (ESR) of the patients. In comparison to the healthy control group, patients with AS had significantly lower scores in each of the five domains of the FSFI except for the pain domain (P<0.05). The disease activity, functional status, quality of life, radiological score and CRP levels were negatively correlated with the FSFI (P<0.05). No significant correlation was observed with the disease duration, smoking status, depression, anxiety, pain and ESR when the total scores and the scores from the domains of the FSFI were compared. The sexual function is impaired in female patients with AS. This impairment in the sexual function is especially related to the functional status and disease activity among the clinical and laboratory parameters.Öğe INCREASED RISK OF ERECTILE DYSFUNCTION ASSOCIATED WITH PREGABALIN IN THE TREATMENT OF NEUROPATHIC PAIN(Wiley-Blackwell, 2014) Daggulli, M.; Soylemez, H.; Bozkurt, M.; Gocmez, C.; Bodakci, M.; Atar, M.; Bozkurt, Y.[Abstract Not Available]Öğe LPS-induced Src family kinases activity mediates IL-10 production through activation of STAT3 in peripheral blood mononuclear cells of patients with Behcet's Disease(C M B Assoc, 2017) Irtegun-Kandemir, S.; Tekin, M. A.; Bozkurt, M.; Dagli, A. Z.; Kalkanli-Tas, S.Behcet's disease (BD) is a chronic inflammatory disorder characterized by recurrent oral and genital ulcers, uveitis and skin lesions. Although, the pathogenesis of BD remains poorly understood, excessive or dysregulated cytokine production including IL-10 is associated with BD. Revealing the key molecular mechanism by which IL-10 expression is regulated is crucial to understanding the pathogenesis of BD. The aim of this study was to investigate whether Src family kinases (SFKs) are upstream mediators of STAT3/IL-10 pathway in peripheral blood mono nuclear cells (PBMCs) of active BD patients. Twenty active BD patients and twenty healthy subjects used as control were included in the study. PBMCs were isolated from total blood by density gradient centrifugation. Western blot and ELISA methods were applied to analyze lipopolysaccharide (LPS)-induced SFKs/STAT3/IL10 signaling pathway in BD. Inhibition of SFKs activity suppressed LPS-induced IL-10 production in PBMCs from both controls and active BD patients. Similarly, blockage of STAT3 activation abrogated LPS-induced IL-10 production. However, LPS-induced STAT3 activation required for IL-10 production was found to be dependent on SFKs activity as LPS-induced STAT3 phosphorylation was reduced by the inhibition of SFKs activity in PBMCs of active BD patients. SFKs activity is essential for LPS-induced STAT3/IL-10 pathway in PBMCs of active BD patients. Manipulation of the SFKs activity may offer a novel therapeutic approach for BD.Öğe Neuroprotective effects of carvacrol and pomegranate against methotrexate-induced toxicity in rats(Verduci Publisher, 2013) Celik, F.; Gocmez, C.; Bozkurt, M.; Kaplan, I.; Kamasak, K.; Akil, E.; Dogan, E.BACKGROUND: Studies related to the use of various antioxidant and anti-inflammatory drugs to decrease the toxic side effects related to MTX have been carried out. However, since no medicine providing full protection against the side effects of MTX has been discovered, the discovery of new agents is required. AIM: The aim of this study was to determine whether methotrexate (MTX) causes oxidative stress and an inflammatory response in sciatic nerve, as well as whether carvacrol (CAR) and pomegranate (POM) have protective effects against the resulting oxidative stress and inflammatory response. MATERIALS AND METHODS: 32 adult male Wistar albino rats were used in the study. The animals were divided into 4 groups: Group C: the rats were not given any medication; Group MTX: On study day 2, the rats were given a single dose of 20 mg/kg MTX, administered intraperitoneally; Group MTX+CAR: On study day one, the rats were administered a single dose of 73 mg/kg CAR intraperitoneally. On study day two, a single dose of 20 mg/kg MTX was administered intraperitoneally; Group MTX+POM: For seven days starting from the study day one, rats were given 225 mg/kg POM extract once a day through orogastric gavage. On study day two, a single dose of 20 mg/kg MTX was administered intraperitoneally. All animals were sacrificed on the day eight. TOS, TAS, MDA, TNF-alpha and IL-1 beta levels were evaluated in the sciatic nerve tissue. RESULTS: In comparison to the control group, a decrease in TAS levels and an increase in TOS, MDA, IL-1 beta and TNF-alpha levels were detected in the MTX group. Compared to the MTX group, the MTX+CAR group had a significant increase in TAS level and significant decreases in TOS, MDA, IL-1 beta and TNF-alpha levels. In comparison to the MTX group, the MTX+POM group had a significant decrease in MDA, IL-1 beta and TNF-alpha levels. When the MTX+CAR and MTX+POM groups were compared, the TNF-alpha level measured was lower in the MTX+CAR group. CONCLUSIONS: In this work, we have shown that MTX causes a significant oxidative stress and inflammatory response in rats' sciatic nerve tissue and that CAR had an antioxidant effect in this system. Furthermore, we have proven, for the first time, that both CAR and POM decreased the pro-inflammatory response.Öğe PROTECTIVE EFFECT OF CARVACROL AGAINST METHOTREXATE-INDUCED TESTICULAR TOXICITY IN RATS(Wiley-Blackwell, 2014) Daggulli, M.; Bodaki, M. N.; Bozkurt, M.; Bozkurt, Y.; Hatipoglu, N. K.; Penpegul, N.; Soylemez, H.[Abstract Not Available]Öğe Protective Effects of Carvacrol Against Methotrexate-induced Liver Toxicity in Rats(Acta Medical Belgica, 2014) Bozkurt, M.; Bodakci, M. N.; Turkcu, G.; Kuyumcu, M.; Akkurt, M.; Sula, B.; Em, S.Background : To investigate whether carvacrol (CAR) pretreatment reduces the severity of methotrexate (MTX)-induced hepatotoxicity in rats. Methods : A total of 24 rats were equally divided into three groups : group I, control; group II, MTX-treated; and group III, CAR+MTX-treated. On Day 1 group III received a one-time intraperitoneal dose of CAR (73 mg/kg), and on Day 2 both groups II and III received a single dose of intraperitoneal MTX (20 mg/kg). The rats were then sacrificed so to harvest blood and liver tissue samples to determine malondialdehyde (MDA), total antioxidant capacity (TAS), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphata.se (ALP) levels. Histological specimens were examined via light microscopy. Results : Levels of MDA, ALT, AST and ALP in rat liver tissue samples were significantly higher in the MTX-treated group relative to the control group. However, TAS was significantly reduced in the MTX-treated group when compared to controls. Pretreating rats with CAR counteracted the effect of MTX exposure as MDA was significantly decreased and TAS was elevated in liver tissues when contrasted with the MTX-treated group. Furthermore, histological examination demonstrated significant liver injury in the MTX-treated group versus the CAR+MTX group. Conclusions : Pretreatment with CAR markedly diminished liver damage induced by MTX. Therefore, CAR administration preceding MTX treatment might be a promising therapeutic modality to prevent and/or lessen the extent of MTX-induced hepatotoxicity.Öğe THE ROLE OF RELAXIN IN BENIGN HYPERMOBILITY SYNDROME(Bmj Publishing Group, 2013) Em, S.; Oktayoglu, P.; Caglayan, M.; Karakoc, M.; Ucar, D.; Bozkurt, M.; Mete, N.[Abstract Not Available]Öğe SERUM COENZYME-Q10 ACTIVITY AND OXIDATIVE STATUS IN PATIENTS WITH FIBROMYALGIA(Bmj Publishing Group, 2013) Bozkurt, M.; Oktayoglu, P.; Ucar, D.; Em, S.; Caglayan, M.; Yuksel, H.; Batmaz, I.[Abstract Not Available]Öğe SERUM LEVELS OF HIGH MOBILITY GROUP BOX 1 PROTEIN AND ITS ASSOCIATION WITH QUALITY OF LIFE AND PSYCHOLOGICAL AND FUNCTIONAL STATUS IN PATIENTS WITH FIBROMYALGIA(Bmj Publishing Group, 2013) Oktayoglu, P.; Caglayan, M.; Bozkurt, M.; Em, S.; Ucar, D.; Yazmalar, L.; Mete, N.[Abstract Not Available]Öğe SLEEP QUALITY IN PATIENTS WITH PSORIATIC ARTHRITIS(Clinical & Exper Rheumatology, 2014) Gezer, O.; Batmaz, I; Sariyildiz, M. A.; Sula, B.; Ucmak, D.; Bozkurt, M.; Nas, K.[Abstract Not Available]Öğe A USEFUL MARKER IN ASSESSMENT OF REMISSION AND ACTIVATION OF DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS: SERUM HUMAN NEUTROPHIL PEPTIDES 1-3(Bmj Publishing Group, 2016) Okcu, M.; Oktayoglu, P.; Mete, N.; Bozkurt, M.; Caglayan, M.; Nas, K.[Abstract Not Available]
