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Öğe Assessment of myocardial performance index and its association with aortic elasticity in patients with ascending aortic aneurysm(Turkish Soc Cardiology, 2016) Baykan, Ahmet Oytun; Gur, Mustafa; Kalkan, Gulhan Yuksel; Acele, Armagan; Seker, Taner; Sen, Omer; Borekci, AbdurrezzakObjective: Ascending aortic aneurysms (AAA) are a leading cause of morbidity and mortality. Nevertheless, their effects on global cardiac functions are yet to be fully understood. Myocardial performance index (MPI) has been widely used to quantitatively assess myocardial functions. The aim of this study was to evaluate left ventricular (LV) functions in patients with AAA using tissue Doppler (TD) echocardiography and MPI in addition to conventional echocardiographic methods. Methods: Fifty patients with AAA (33 men, 17 woman; mean age 55.5+/-7.90 years) were included, and 106 patients without aortic dilatation (mean age 54.1+/-8.18 years) were included as the control group. LV systolic and diastolic functions were analyzed using 2-dimensional, M-mode, and TD echocardiography. Results: Patients with AAA had significantly higher MPI (0.5+/-0.04 vs 0.4+/-0.05, p<0.001), TD-MPI (0.5+/-0.02 vs 0.4+/-0.03, p<0.001), and reduced aortic elasticity, as indicated by reduced aortic distensibility (AD) (1.7+/-1.27 vs 3.1+/-1.25, p<0.001). Multivariate linear regression analysis showed that TD-MPI was independently correlated with reduced aortic distensibility (B=-0.006, p=0.019, 95% confidence interval,-0.011 to -0.001). Conclusion: MPI and TD-MPI indicated impairment of global cardiac functions in patients with AAA, which may be attributed to reduced aortic elasticity.Öğe Epicardial fat thickness as associated with left ventricular myocardial performance in patients with newly diagnosed hypertension(Turkish Soc Cardiology, 2015) Borekci, Abdurrezzak; Gur, Mustafa; Seker, Taner; Ucar, Ayse Kalyoncu; Baykan, Ahmet Oytun; Elbasan, Zafer; Harbalioglu, HazarObjective: Epicardial fat thickness (EFth) is associated with both left ventricular hypertrophy (LVH) and diastolic dysfunction. However, the effect of EFth on myocardial performance is not known. The aim of this study was to investigate the relationship between EFth and tissue Doppler myocardial performance index (TD-MPI), which incorporates both systolic and diastolic left ventricular (LV) function, in newly diagnosed hypertension (HT) patients. Methods: A total of 314 consecutive, newly diagnosed HT patients were prospectively included (mean age: 51.9 +/- 1.7 years). EFth was measured perpendicularly on the free wall of the right ventricle at the end of the systole in 2 echocardiographic views (parasternal short and long axis). Myocardial performance index (MPI) was calculated using tissue Doppler (TD) echocar-diography. Patients were divided into 2 groups according to median TD-MPI levels (TD-MPIlow and TD-MPIhigh). Results: EFth values of the TD-MPIhigh group were higher than those of the TD-MPIlow group (p<0.05). Patients in the TD-MPIhigh group also had higher age, body mass index, systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular mass index (LVMI), E/A ratio, and aortic distensibility, compared with the TD-MPIlow group (p<0.05 for all). Multivariate linear regression analysis showed that TD-MPI was independently associated with age (beta= 0.089, p= 0.012), LVMI (beta= 0.090, p= 0.05), E/A (beta=-0.118, p=0.005), and EFth (beta= 0.432, p<0.001). Conclusion: TD-MPI was independently associated with EFth in patients with newly diagnosed HT. EFth may be used as a predictor of impaired LV global functions in patients with normal left ventricular ejection fraction (LVEF) and newly diagnosed HT.Öğe Neutrophil to Lymphocyte Ratio Predicts Left Ventricular Remodeling in Patients with ST Elevation Myocardial Infarction after Primary Percutaneous Coronary Intervention(Korean Soc Cardiology, 2016) Borekci, Abdurrezzak; Gur, Mustafa; Turkoglu, Caner; Baykan, Ahmet Oytun; Seker, Taner; Sahin, Durmus Yildiray; Harbalioglu, HazarBackground and Objectives: It has been demonstrated that the neutrophil/lymphocyte ratio (NLR) might be a useful marker to predict cardiovascular risk and events. We aimed to investigate the role of the NLR to predict ventricular remodeling (VR) in patients with anterior ST-elevation myocardial infarction (STEMI) who were treated with primary percutaneous coronary intervention. Subjects and Methods: We prospectively included 274 consecutive anterior STEMI patients. Echocardiography was performed during admission and at six months after myocardial infarction. VR was defined as at least 200/0 increase from baseline in left ventricular end diastolic volume. Patients were divided into two groups according to their VR status: VR (n=67) and non-VR (n=207). Total and differential leukocyte count, N -terminal pro -brain natriuretic peptide (NT-proBNP) and other biochemical markers were measured at admission and 24 hours later. Results: Compared with the non-VR group, peak creatine kinase MB (CK-MB), NT-proBNP (24 h), neutrophil/lymphocyte ratio, presence of diabetes, no-reflow frequency and wall motion score index were significantly higher in patients with VR (p<0.05 for all). On multivariate logistic regression analysis, NLR (beta=2.000, 950/o confidence interval=1.577-2.537, p<0.001) as well as peak CK-MB, NT-proBNP (24 h), WMSI and diabetes incidence were associated with VR. The cutoff value of the neutrophil/lymphocyte ratio obtained by receiver operator characteristic curve analysis was 4.25 for the prediction of VR (sensitivity: 79%, specificity: 74%). Conclusion: In patients with anterior STEMI, initial NLR and NT-proBNP measured 24 hours after admission may be useful for predicting adverse cardiovascular events including left VR.Öğe Relationship between epicardial fat thickness and hypertension Reply(Turkish Soc Cardiology, 2016) Borekci, Abdurrezzak; Gur, Mustafa; Ucar, Hakan; Seker, Taner; Cayli, Murat[Abstract Not Available]
