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    Activity, acute and sub-acute toxicity and safety assesment of the hydroalcholic root extract of Diplotaenia turcica
    (Agricultural Research Communication Centre, 2018) Ozdek, U.; Basbugan, Y.; Yildirim, S.; Boga, M.; Firat, M.; Deger, Y.
    Diplotaenia turcica is widely utilized in conventional treatment in the east of Turkey. Due to the insufficient data on the safety profile, the acute and sub acute toxicity of Diplotaenia turcica was determined. Furthermore, total phenolic content, flavonoid content and antioxidant activity of the extract were determined. The acute toxicity of hydroalcoholic root extract of Diplotaenia turcica (HREDT) was evaluated in mice after administration of single oral dose at the 5000 mg/kg (acute model) and rat after 28 days orally administration at the dose range of 250, 500 and 1000 mg/kg (subacute model). According to result, the LD50 value of HREDT was found to be greater than 5000 ing/kg. In sub acute toxicity study, no statistically significant differences were observed in the values of hematological and pathological parameters in comparison with control group. It was determined that the glucose, triglyceride, cholesterol and LDL levels exerted a significant effect depending on the HREDT doses. The results from the present study found out that HREDT did not produce any toxic effects or deaths in animals for both single and chronic administration. Additionally, HREDT showed moderate antioxidant activities and exhibited relatively notable total phenolic content.
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    Electrical Characterization of Au/Quercetin/n-Si Heterojunction Diode and Optical Analysis of Quercetin Thin Film
    (Amer Inst Physics, 2016) Tombak, Ahmet; Ozaydin, C.; Boga, M.; Kilicoglu, T.
    Quercetin (3,5,7,3',4'-pentahydroxyflavone, QE), one of the most widely distributed flavonoids in fruits and vegetables, has been reported to possess a wide variety of biological effects, including anti-oxidative, anti-inflammatory, anti-apoptosis, hepatoprotective, renoprotective and neuroprotective effects. In this study organic-inorganic junctions were fabricated by forming quercetin complex thin film using spin coating technique on n-Si and evaporating Au metal on the film. Optical properties of quercetin thin film were studied with the help of spectrophotometer. The current-voltage (I-V) characteristic of Au/quercetin/n-Si heterojunction diode was investigated at room temperature in dark. Some basic parameters of the diode such as ideality factor, rectification ratio, barrier height, series resistance and shunt resistance were calculated using dark current-voltage measurement. It was also seen that the device had good sensitivity to the light under 40-100 mW/cm(2) illumination conditions.
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    Phytochemical analysis, antioxidant, antimicrobial, anticholinesterase and DNA protective effects of Hypericum capitatum var. capitatum extracts
    (Elsevier Science Bv, 2016) Boga, M.; Ertas, A.; Eroglu-Ozkan, E.; Kizil, M.; Ceken, B.; Topcu, G.
    This is the first study on phytochemical analysis and biological evaluation of Hypericum capitatum Choisy var. capitatum (HCC) endemic to Turkey with exception of essential oil analysis. Hyperoside and isoquercetin (25.7 +/- 0.02 and 17.8 +/- 0.02 mu g/mg extract, respectively) were determined as the main compounds of the methanol extract. The major compounds of essential oil of HCC were found to be spathulenol and iso-longifolene (12.9% and 11.2%, respectively), and linoleic and palmitic acids (26.8% and 18.3%, respectively) were the main fatty acids. The methanol extract whose antioxidant activities studied for the first time was found to have moderate activity in beta-carotene bleaching method (IC50: 41.69 +/- 1.29 mu g/mL) and was found to be the most active extract in scavenging of DPPH free radical (IC50: 16.82 +/- 0.58 mu g/mL) and ABTS cation radical (IC50: 9.24 +/- 0.28 mu g/mL) and CUPRAC assays. Among the prepared four extracts of HCC, the methanol extract showed highest activity against Escherichia coli with an MIC value of 10 mu g/mL, and the methanol extract was also found to have high DNA damage protective activity. The methanol extract exhibited high butyrylcholinesterase inhibitory activity (70.74%). Thus, H. capitatum var. capitatum can be regarded as a potential natural antioxidant, antimicrobial, anticholinesterase source and DNA damage inhibitor. (C) 2016 SAAB. Published by Elsevier B.V. All rights reserved.