Yazar "Bilici, Salim" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • [ X ]
    Öğe
    Analysis of Complications of a Neglected Disease: 13 Years of Experience with Liver Hydatid Cysts in a High-Volume Hospital
    (Mdpi, 2024) Azizoglu, Mustafa; Aydogdu, Bahattin; Kamci, Tahsin Onat; Arslan, Serkan; Basuguy, Erol; Bilici, Salim; Okur, Mehmet Hanifi
    Background and Objectives: The aim of this study was to evaluate the clinical presentation, treatment outcomes, and complications associated with hepatic hydatid cysts in a pediatric population. Materials and Methods: This retrospective study analyzed 214 pediatric patients with liver hydatid cysts, focusing on clinical presentation, treatment outcomes, and associated complications. Patients were classified based on treatment modality, including non-operative management with albendazole, PAIR, and surgical intervention. This study compared cyst characteristics, recurrence rates, and complications such as cysto-biliary fistulas. Results: Among the patients, 68% (n = 145) had a single cyst and 86% (n = 184) were found to have isolated liver cysts. No significant statistical difference was observed between Group 1 and Group 2 in terms of age, gender, and basic laboratory values and general characteristics of the cysts, such as the lobe where the cyst was located, involvement of multiple organs, number of cysts, the state of cyst rupture, and recurrence; no statistically significant difference was found between the groups (p > 0.05 for each comparison). Cyst rupture incidence was 6%, and the average incidence of recurrence was 2%, with a surgical recurrence incidence of 3%. A total of 37 patients had a laparotomy, while 7 had laparoscopic surgery. In total, capitonnage was performed in 68 patients, omentopexy in 4, and cystostomy in 6. Consequently, among the treated patients (PAIR + surgery), the incidence of cysto-biliary fistula was 11%, anaphylaxis was 2%, surgical recurrence was 3%, and the incidence of reoperation (Clavien-Dindo >= 3) was 6%. The average follow-up period was 72 months, during which no mortality was observed. Conclusions: We identified key clinical outcomes related to both non-surgical treatments (cyst rupture and recurrence) and surgical groups (cysto-biliary fistulas, anaphylaxis, the need for reoperation, rupture, and recurrence).
  • Küçük Resim
    Öğe
    Diyarbakır yöresi Ailevi Akdeniz Ateşli çocuklarda MEFV gen mutasyon sıklıkları
    (Dicle Üniversitesi Tıp Fakültesi, 2009) Evliyaoğlu, Osman; Bilici, Salim; Yolbaş, İlyas; Kelekçi, Selvi; Şen, Velat
    Ailevi Akdeniz Ateşi otozomal resesif bir hastalık olup, periyodik karın ağrısı, ateş ve eklem ağrısı ile karakterizedir. Ailevi Akdeniz Ateşinden sorumlu tutulan MEFV geninde bir çok mutasyon belirlenmiştir. Bu çalışmamızda klinik olarak Ailevi Akdeniz Ateşi şüphesi taşıyan toplam 332 çocuktan DNA örnekleri alındı ve 12 MEFV mutasyonu [E148Q, P369S, F479L, M680I (G/C), M680I (G/A), I692del, M694V, M694I, K695R, V726A, A744S, R761H] ters hibridizasyon yöntemi ile yapıldı. Toplam 113 çocukta (ortalama yaş: 11.5 yıl) mutasyon tespit edildi. E148Q mutasyonu 60 çocukta (4 tanesi homozigot), M694V mutasyonu (4 tanesi homozigot) 19 çocukta, P369S mutasyonu (homozigot mutasyon yoktu) 16 hastada ve V726A mutasyonu (homozigot mutasyon yoktu) 13 çocukta tespit edildi. Ancak Ailevi Akdeniz Ateşi şüphesi ile mutasyon analizi istenen 332 çocuktan toplam olarak 104’ünde tanı kriterlerine göre hastalığın tanısı klinik olarak doğrulandı. Ailevi Akdeniz Ateşi tanısı alan hastalarda gen mutasyonları sıklık sırasına göre; E148Q (%30.8), M694V (%18.3), P369S (%10.6), V726A (%8.6), A744S (%2.9), R761H (%2.9), M694I (%1.9), K695R (%1.9) ve I692del (%1.0). Ailevi Akdeniz Ateşi tanısı konan hastaların 15’inde (%14.4) hiçbir mutasyon saptanmazken, 13’ünde (%12.5) iki farklı mutasyon aynı anda belirlenerek bileşik heterezigot olarak tanımlandı. Sonuç olarak hastalarımızda E148Q mutasyonuna, normalde en sık görülen M694V mutasyonundan daha sık rastlandı. Bu farklılık demografi k yapı veya metot ile ilişkili olabilir.
  • Küçük Resim
    Öğe
    Laparoscopic versus open portoenterostomy for treatment of biliary atresia: a meta-analysis
    (Springer Science and Business Media, 2023) Okur, Mehmet Hanifi; Aydoǧdu, Bahattin; Azizoǧlu, Mustafa; Bilici, Salim; Bayram, Salih; Salık, Fikret
    Objective: Our goal was to compare laparoscopic portoenterostomy versus open portoenterostomy for the treatment of biliary atresia. Materials and methods: Using the databases EMBASE, PubMed, and Cochrane, we carried out a thorough literature search up to 2022. Studies comparing laparoscopic and open surgery for the treatment of biliary atresia were included. Results: Twenty-three studies comparing laparoscopic portoenterostomy (LPE) (n = 689) and open portoenterostomy (OPE) (n = 818) were considered appropriate for meta-analysis. Age at surgery time was lower in the LPE group than OPE group (I2 = 84%), (WMD − 4.70, 95% CI − 9.14 to − 0.26; P = 0.04). Significantly decreased blood loss (I2 = 94%), (WMD − 17.85, 95% CI − 23.67 to − 12.02; P < 0.00001) and time to feed were found in the laparoscopic group (I2 = 97%), (WMD − 2.88, 95% CI − 4.71 to − 1.04; P = 0.002). Significantly decreased operative time was found in the open group (I2 = 85%), (WMD 32.52, 95% CI 15.65–49.39; P = 0.0002). Weight, transfusion rate, overall complication rate, cholangitis, time to drain removal, length of stay, jaundice clearance, and two-year transplant-free survival were not significantly different across the groups. Conclusions: Laparoscopic portoenterostomy provides advantages regarding operative bleeding and the time to begin feeding. No differences in remain characteristics. Based on the data presented to us by this meta-analysis, LPE is not superior to OPE in terms of overall results.
  • [ X ]
    Öğe
    Unusual Histopathological Findings in Appendectomy Specimens Obtained from 1683 Pediatric Patients with Suspected Acute Appendicitis
    (Springer India, 2019) Oztas, Tulin; Dursun, Ahmet; Sogutcu, Nilgun; Bilici, Salim
    The aim of this study is to emphasize the importance of rare histopathological findings in appendix specimens of pediatric patients who underwent surgery for the preliminary (underwent appendectomy to treat an initial diagnosis) diagnosis of acute appendicitis. In this study, the demographic and histopathologic data of 1683 patients who underwent surgery for (presumed acute appendicitis) acute appendicitis between 2011 and 2017 were retrospectively evaluated. Appendectomy specimens were classified microscopically as appendix vermiformis, lymphoid hyperplasia, acute appendicitis, phlegmonous appendicitis, gangrenous appendicitis, perforated appendicitis, and unusual histopathological findings. Age, sex, clinical features, surgical reports, and macroscopic and microscopic features of appendix vermiformis were evaluated in patients with unusual histopathological findings. Ages of these 1683 patients ranged between 6 months and 17 years; among them, 1091 were men and 592 were women. Pathology reports included acute appendicitis (n = 827), phlegmonous appendicitis (n = 300), lymphoid hyperplasia (n = 274), perforated appendicitis (n = 181), appendix vermiformis (n = 50), gangrenous appendicitis (n = 3), and abnormal findings (n = 48). Of the 48 patients who were detected to have unusual findings, 32 were women and 16 were men and their ages ranged from 6 to 17 years. The frequency of unusual histopathological findings were as follows: Enterobius vermicularis (n = 37), fibrous obliteration (n = 6), neuroendocrine tumor (n = 2), mucinous neoplasm (n = 1), pseudodivericulitis (n = 1), and foreign body in the lumen (n = 1). No tumor recurrence or distant metastasis developed during the 2-year follow-up in any of the three patients detected to have a tumor. Even if the appendectomy specimen is normal during the surgery, histopathologic evaluation is necessary for the diagnosis of diseases that require treatment and follow-up after surgery.