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    The effect of platelet-albumin ratio on mortality and morbidity in peptic ulcer perforation
    (Lippincott Williams & Wilkins, 2022) Bilge, Huseyin; Basol, Omer
    Background: The aim of our study was to investigate the prognostic role of platelet/albumin ratio in patients treated under emergency conditions for peptic ulcer perforation (PUP). Methods: A retrospective study involving emergency patients who were operated for PUP was carried out. The patients were divided into 2 groups: PUP patients who died after surgical treatment (PUP-M) and PUP patients who survived after surgical treatment (PUP-S). The laboratory values of the patients were compared statistically. A P value of Results: This cohort study consisted of 171 patients treated between June 2013 and December 2019. The mean age of the patients was 46.3 +/- 20.5 years; and 33 (19.3%) patients were women. The age (P <= .001), platelet/lymphocyte ratio (P = .02), lactic dehydrogenase to albumin ratio (P <= .001), and platelet/albumin ratio (PAR; P <= .001) values were high and lymphocyte count was low (P = .006) in the PUP-M group. A positive correlation was determined between length of stay in hospital and age (P <= .001), lactic dehydrogenase/albumin ratio (P <= .001), platelet count (P = .044), and PAR (P <= .001). A substantial negative correlation was determined between length of stay in hospital and albumin count (P <= .001). Conclusions: We determined a high preoperative PAR level in PUP patients who had undergone surgery as a negative prognostic parameter. PAR is a candidate biomarker for clinical practice.
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    Investigation of the effects of sildenafil on liver and remote organ in hepatic ischemia-reperfusion damage
    (Wolters Kluwer Medknow Publications, 2020) Cetin, Erman; Oguz, Abdullah; Basol, Omer; Bilge, Huseyin
    Introduction The aim of this study was to demonstrate whether sildenafil is effective in minimizing and/or eliminating hepatic ischemia/reperfusion injury effects. For this purpose, the authors experimentally performed biochemical and histopathological examinations of the included rats using the hepatic ischemia/reperfusion model. Materials and methods The authors used 40 animals, with 10 rats in each group, in this study. Ischemia was applied 30-45min with the hepatoduodenal ligament clamping, and then reperfusion is started. The rats were grouped as follows: the first group, only laparotomy; the second group, laparotomy and sildenafil; the third group, hepatic ischemia-reperfusion; and the fourth group, hepatic ischemia-reperfusion and sildenafil. During experimental studies, sildenafil capsules were opened, and appropriate dose required for animals had been created with the weighing scales. Then, the powder was diluted with saline. The authors gave sildenafil through oral gavage 15 minutes before the ischemia. 60min after starting the experiment in 1-2 groups and 30min after beginning reperfusion in 3-4 groups (60min after beginning the experiment in all groups), blood was taken from the animals for biochemical analysis, and the animals were sacrificed. Simultaneously liver, lung, and kidney tissues were removed for biochemical and histopathological examination. Results Based on plasma evaluation, total antioxidant status was lower (P=0.0274) in ischemia/reperfusion group compared with ischemia/reperfusion+sildenafil group. However, there was no difference between the groups regarding total oxidant status values (P=0.0274). When comparing total antioxidant status and oxidative stress index in liver tissue, a statistically significant difference was observed between groups (P=0.012766 and P=0.004081), but on comparing histopathological scores, there was no difference between groups (P=0.1244). Conclusion Sildenafil partly reduced the effects of hepatic ischemia-reperfusion injury on the liver and distant organs, although this difference was not statistically significant.
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    Rectus Sheath Hematoma-a Hitherto Less Described Entity
    (Springer India, 2021) Basol, Omer; Bilge, Huseyin; Kirsan, Mehmet Ali; Yaman, Gizem
    Rectus sheath hematoma is a rare condition that is manifested by abdominal wall pain and stiffness in the abdominal wall. It is usually a result of the rupture of the epigastric vessels or rectus muscle into the lower part of the umbilical region. Surgical intervention is rarely required due to diagnosis and uncontrollable growth. Twenty-two patients who were diagnosed and followed up with rectus sheath hematoma between January 2010 and January 2020 in Dicle University Medical Faculty, Clinic of General Surgery, were retrospectively reviewed for demographic features, clinical and radiological findings, and length of hospital stay. The most common complaints of patients with rectus sheath hematoma were abdominal wall pain, swelling, ecchymosis, and mass on the abdominal wall. The average age of the patients was 63 (22-78) years. Twenty of the patients were women and 2 of them were men. None of the patients had a history of trauma, and all were using anticoagulant drugs. In radiological imaging, types of rectus sheath hematoma were type 1 in twelve patients, type 2 in seven, and type 3 in three. Firstly, anticoagulant medications used by patients were discontinued. Then, all patients, except two who were undertaken surgery, were treated conservatively. The reason for the surgery was rapid and widespread growth of hematoma. The average length of hospital stay was 7 (6-13) days. At the end of the first month after diagnosis and treatment, computed tomography revealed that the mass disappeared in patients with type 1 rectus sheath hematoma, while the other patients had a marked reduction in mass size. In patients with an abdominal wall pain, anemia, a mass/ecchymosis on anterior abdominal wall, and history of anticoagulant medication, rectus sheath hematoma should be considered in the differential diagnosis. Early diagnosis of rectus sheath hematoma ensures the prevention of unnecessary surgical interventions and determines the success of conservative treatment.
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    Retrospective analysis of metabolic effects of laparoscopic gastric plication and single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S)
    (Edizioni Luigi Pozzi, 2023) Cayoren, Huseyin; Yigitbas, Hakan; Aktokmakyan, Talar Vartanoglu; Bilge, Huseyin; Solmaz, Ali; Kutanis, Riza
    AIM: The aim of this study is to investigate the clinical outcomes of patients with type 2 diabetes mellitus (T2DM) who underwent laparoscopic gastric plication (LGP) or single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADIS) and analyze the postoperative first-year results of these two operations. METHODS: Forty-three patients who have undergone LGP and 36 patients who had undergone SADI-S were included in this study. Baseline and postoperative first-year data of patients with T2DM who have undergone LGP or SADI-S in our clinic between January 1, 2013, and June 30, 2016, were retrospectively analyzed. RESULTS: It is understood that both operations maintained a remarkable improvement in blood glucose parameters alongside total cholesterol and triglyceride levels. The complete diabetes remission rate was significantly higher in the SADI-S group than in the LGP group (69.4% vs. 42.1%, p=0.018). LGP group achieved better results than SADI-S on weight loss in terms of the percentage excess weight loss (EWL%) (p<0.001) and the percentage total weight loss (TWL%) (p<0.001). CONCLUSION: In our study, both operations facilitated diabetes remission, and complete remission or improvement was obtained in most of the cases. In addition, statistically significant weight loss was observed in both procedures. Therefore, both bariatric techniques can be chosen for obese diabetic patients considering their priorities and needs.
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    Retrospective analysis of metabolic effects of laparoscopic gastric plication and single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S)
    (Edizioni Luigi Pozzi, 2023) Cayoren, Huseyin; Yigitbas, Hakan; Aktokmakyan, Talar Vartanoglu; Bilge, Huseyin; Solmaz, Ali; Kutanis, Riza
    AIM: The aim of this study is to investigate the clinical outcomes of patients with type 2 diabetes mellitus (T2DM) who underwent laparoscopic gastric plication (LGP) or single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) and analyze the postoperative first-year results of these two operations. METHODS: Forty-three patients who have undergone LGP and 36 patients who had undergone SADI-S were included in this study. Baseline and postoperative first-year data of patients with T2DM who have undergone LGP or SADI-S in our clinic between January 1, 2013, and June 30, 2016, were retrospectively analyzed. RESULTS: It is understood that both operations maintained a remarkable improvement in blood glucose parameters alongside total cholesterol and triglyceride levels. The complete diabetes remission rate was significantly higher in the SADI-S group than in the LGP group (69.4% vs. 42.1%, p=0.018). LGP group achieved better results than SADI-S on weight loss in terms of the percentage excess weight loss (EWL%) (p<0.001) and the percentage total weight loss (TWL%) (p<0.001). CONCLUSION: In our study, both operations facilitated diabetes remission, and complete remission or improvement was obtained in most of the cases. In addition, statistically significant weight loss was observed in both procedures. Therefore, both bariatric techniques can be chosen for obese diabetic patients considering their priorities and needs.