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Öğe The effectiveness of combined preventive treatment with Ceftiofur, Oxytocin and PGF2? on fertility parameters in cows(Ecole Nationale Veterinaire Toulouse, 2012) Kaya, D.; Ay, S. S.; Kucukaslan, I.; Beceriklisoy, H. B.; Agaoglu, A. R.; Findik, M.; Ozyurtlu, N.The present study is aimed at evaluating the effectiveness of combined preventive treatment with Ceftiofur Hydrochloride (CHR), Oxytocin (OXT) and PGF(2 alpha) on fertility parameters and puerperal disorder rates in postpartum (pp) dairy cows. A total of 191 Holstein-Friesian cows were divided into four groups. The cows in group I (GI; n=37) and II (GII; n=69) were treated on a daily basis with CHR and OXT for five and three days pp, respectively. Group III (GIII; n=52) was designed as the PGF(2 alpha) group, and group IV (GIV; n=33) served as a control group. The animals in GI, GII, and Gill were given a PGF(2 alpha) analogue on days 15 and 26 pp. Each group was further divided into subgroups of normal parturition (np) and dystocia (d) when the study results were evaluated. It was found that the first service pregnancy rates for the subgroup of dystocia were significantly higher (P<0.05 and P<0.01) in subgroup GII (76.9%) than in GI (30.0%) and GIV (37.5%). Furthermore, the median time to first service and the median time to pregnancy were longer for cows in subgroup GIVd as compared with subgroups GId, GIId, and GIIId (P<0.001; P<0.01). Group II was found to have the lowest endometritis rates after treatment of subgroups-d and -np. No statistically significant difference was found between the groups with regard to cystic ovary rates after treatment (P>0.05). As the treatment with CHR-OXT combined with PGF(2 alpha) on days 15 and 26 was associated to improved uterine involution patterns and reproductive performance, our results suggest that administration of this preventive treatment would be useful, especially for cases of dystocia.Öğe Effectiveness of Thuja occidentalis and Urtica urens in pseudopregnant bitches(B W K Publishing Solutions & Verlag, 2008) Beceriklisoy, H. B.; Ozyurtlu, N.; Kaya, D.; Handler, J.; Aslan, S.The aim of this study was to investigate the effectiveness of Thuja occidentalis and Urtica urens in pseudopregnant bitches. Clinically pseudopregnant bitches (n=38) were assigned per random to groups as follows: Group I: Thuja occidentalis D30 (8 globules, 3 times a day, per os, n=15); Group II: Urtica urens D6 (8 globules, 3 times a day, per os, n=15); Group III: naloxone (control group, 0.01 mg/kg, twice daily, s.c., n=8). Treatments were continued until clinical signs resolved. Animals were classified as no, mild, moderate, and severe (score -, +, ++, and +++) according to the clinical signs of mammary glands and behavioural signs during the study. Bitches were examined at 3-5 days intervals by means of adspection and palpation until clinical signs resolved. Successful recovery rates (100 %) were found in Group I and II. Application of naloxone was found to be successful in only 3 of 8 bitches (37.5 %). Mean duration of treatments in Group I, II and III was 11.6 +/- 4.6 (min-max: 3-18) days, 13.5 +/- 3.7 (min-max: 6-19) days and 14.3 +/- 5.9 (min-max: 10-21) days, respectively. During treatment with Thuja occidentalis D30 and Urtica urens D6, the percentages of bitches with behavioural problems significantly decreased within 3-5 days from 33.3 % to 6.7 % (p=0.033) and from 66.7 % to 33.3 % (p=0.050), respectively. All bitches treated with Thuja occidentalis D30 or Urtica urens D6 showed normal behaviour within 10 days after onset of treatments but 2 bitches in the naloxone group kept showing behavioural signs until Days 15-20 of treatment. Concerning mammary gland scores, treatments yielded significantly higher success rates in Group I and Group II (100 in both groups) compared to the success rate observed in Group III (37.5 %; p=0.012). No side effects were observed during the study. In conclusion, the homeopathic agents Thuja occidentalis D30 and Urtica urens D6 proved to be effective and safe in pseudopregnant bitches.Öğe Is Apoptosis a Regulatory Mechanism During Early Canine Pregnancy?(Wiley-Blackwell, 2012) Schaefer-Somi, S.; Sabitzer, S.; Klein, D.; Tomaszewski, C.; Kanca, H.; Beceriklisoy, H. B.; Kucukaslan, I.Contents Fas is a membrane-bound protein which upon activation causes programmed cell death. Fas ligand (FasL) binds Fas on target cells. Both these factors are known to regulate apoptosis at implantation in different species and thus might be involved in the regulation of implantation in dogs. The aim of the study was to assess the expression of Fas and FasL in canine uterine tissue throughout pregnancy as well as in pre-implantation embryos using RT-PCR and RT-qPCR. Uterine tissues was collected from of 21 healthy pregnant bitches (group I: days 1012, n=5; group II: days 1825, n=6; group III: days 2845, n=6) and from 4 non-pregnant bitches (controls: days 1012). Pregnancy stage was determined by days after mating, that is, 23days after ovulation as determined by vaginal cytology and progesterone measurement. After ovariohysterectomy, uteri from group I bitches were flushed with PBS and the embryos washed and stored frozen at -80 degrees. Tissues from the other groups were taken from the implantation and placentation sites, respectively, covered with Tissue Tek (R) and frozen at -80 degrees. Extraction of RNA was performed with Trizol Reagent and RT-qPCR using SYBR green probes. In pre-implantation embryos, only FasL but not Fas could be detected. In all tissues from pregnant and non-pregnant bitches, both parameters were detectable. Before implantation (group I) expression of FasL resembled that of non-pregnant bitches in early dioestrus and decreased significantly during implantation and thereafter (p<0.05). Expression of Fas did not change significantly until day 45. The relative expression of Fas exceeded that of FasL at each stage investigated, which is comparable to observations of other species; however, high standard deviations indicate high individual differences. These preliminary results point towards a regulatory function of the Fas/FasL system during early canine pregnancy.Öğe Vascular Endothelial (VEGF) and Epidermal Growth Factor (EGF) as well as Platelet Activating Factor (PAF) and receptors are expressed in the early pregnant canine uterus(Wiley-Blackwell, 2012) Schaefer-Somi, S.; Sabitzer, S.; Klein, D.; Reinbacher, E.; Kanca, H.; Beceriklisoy, H. B.; Kucukaslan, I.[Abstract Not Available]
