Yazar "Bayhan G." seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • [ X ]
    Öğe
    Cis-platinum combination chemotherapy during pregnancy for mucinous cystadenocarcinoma of the ovary. Case report
    (1999) Bayhan G.; Aban M.; Yayla M.; Gül T.; Yaldiz M.; Erden A.C.
    [No abstract available]
  • [ X ]
    Öğe
    A comparative study of a gonadotropin-releasing hormone agonist and finasteride on idiopathic hirsutism
    (2000) Bayhan G.; Bahçeci M.; Demirkol T.; Ertem M.; Yalinkaya A.; Erden A.C.
    Objective: To compare the efficacy of finasteride and GnRH agonist in the treatment of idiopathic hirsutism. Methods: Sixty women with hirsutism were randomly assigned to receive either 5 mg of finasteride or long-acting GnRH agonist (depot leuprolide 3.75 mg) intramuscularly monthly for six months. Main outcome measures: Hirsutism scores were measured according to the Ferriman-Gallway scoring system, and side-effects were monitored for six months of treatment. Blood samples were taken at each visit for assessment of endocrine (FSH, LH, estradiol, progesterone, total and free testosterone, androstenedione, DHEAS-S, 17-OH-P, SHBG), biochemical, and hematologic parameters. Results: All of the patients treated with finasteride or GnRH agonist showed neither menstrual abnormalities nor side-effects. The mean percent change (±SD) in hirsutism scores in the GnRH and finasteride groups was 36%±14% and 14%±11% at six months, respectively. Serum total testosterone, free testosterone, androstenedion and DHEA-S showed a meaningful decrease in patients treated with GnRH agonist. On the other hand, only serum total testosterone and free testosterone levels decreased with finasteride treatment (p<0.05 and p<0.0001, respectively).
  • [ X ]
    Öğe
    Primary gastric choriocarcinoma: Case report
    (2000) Bayhan G.; Yaldiz M.; Yalinkaya A.; Kilinç N.; Gül T.; Erden A.C.
    [No abstract available]
  • [ X ]
    Öğe
    Significance of changes in lipid peroxides and antioxidant enzyme activities in pregnant women with preeclampsia and eclampsia
    (2000) Bayhan G.; Atamer Y.; Atamer A.; Yokus B.; Baylan Y.
    This review addresses the general hypothesis that the pathogenesis of preeclampsia and enclampsia are related to an imbalance of increased oxidative stress and lipid peroxidation coupled with a deficiency of antioxidant protection. Accordingly, this study was initiated to assess total antioxidant status and free-radical activity in preeclampsia and eclampsia. The patients studied were 44 healthy pregnant women and 45 women with hypertension classified as having preeclampsia (n = 27), and eclampsia (n = 18). The serum levels of lipid peroxide were significantly increased (p < 0.0001) and antioxidant enzyme activities (superoxide dismutase and gluthathione levels) in erythrocytes were significantly decreased (p < 0.0001) in women with preeclampsia and eclampsia compared with the controls. The groups of preeclampsia and eclampsia had similar values of catalase activities as the controls (p > 0.05). There were no correlations between serum levels of lipid peroxide and antioxidant enzyme activities or systolic-diastolic blood pressure of pregnant women with preeclampsia and eclampsia. The mean systolic and diastolic blood pressure, the serum lactate dehydrogenase (LDH) and aspartate transaminase (AST) levels of preeclamptic and eclamptic women were high, whereas haemoglobin (Hb), Hematocrit (Htc) and platelet levels were lower than those of the control subjects (p < 0.0001). There were no differences in mean gestational week, whereas the mean age of eclamptic women was lower than that of the other two groups (p < 0.001). The serum levels of Alanin-transaminasis (ALT) and urea in eclamptic women were significantly higher compared with the other two groups (p < 0.0001), whereas creatinin levels were lower than those of the other two groups (p < 0.05). Our findings give support to those few studies considering lipid peroxidation as an important factor in the pathogenesis of preeclampsia and eclampsia. Further studies are needed to clarify the relations between lipid peroxidation and antioxidative function and their pathophysiological significance in preeclampsia and eclampsia.