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Öğe Atretic parietal cephalocele(Karger, 2007) Guzel, Aslan; Tatli, Mehmet; Er, Uygur; Bavbek, Murad[Abstract Not Available]Öğe Azathioprine as a neuroprotective agent in experimental traumatic spinal cord injury(Turkish Neurosurgical Society, 2021) Bahadır, Sinan; Önal, Mehmet Bülent; Narin, Fırat; Başar, İbrahim; Yigitkanlı, Kazım; Bavbek, Murad; Ziyal, Mustafa İbrahimAIM: To evaluate the protective effects of azathioprine, a macrophage-inhibiting agent, on secondary injury in spinal cord trauma. MATERIAL and METHODS: A total of 40 Wistar rats were randomly divided into 4 groups. All the animals had undergone T8-10 laminectomy. Except in group I (control), all the animals were exposed to spinal cord trauma at the T9 level. Animals in group II (trauma) received no treatment following trauma. Animals in group 3 (treatment) and group IV (vehicle) were given intraperitoneal azathioprine 4 mg/kg and saline 2 ml, respectively, 30 minutes after the trauma. Half of the animals in each group were sacrificed 24 hours after injury and specimens were used for biochemical and immunohistochemical evaluations. The rest of the animals were followed-up for 4 weeks in terms of neurological functions and were also sacrificed to perform the histopathological analysis. RESULTS: Significant decrease in apoptotic cells and improved neurological function were observed in the animals treated with azathioprine. Biological and immunohistochemical analysis also showed less oxidative stress in this group compared to those without treatment. CONCLUSION: Azathioprine, a potent macrophage-inhibiting agent, has been shown to decrease the extent of secondary injury following spinal cord trauma.Öğe Multifocal Ewing's sarcoma of the brain, calvarium, leptomeninges, spine and other bones in a child(Elsevier Sci Ltd, 2008) Guezel, Aslan; Tatli, Mehmet; Er, Uygur; Yimaz, Fahri; Bavbek, MuradEwing's sarcoma (ES) is a malignant osseous neoplasm that mostly affects children and young male adults, and usually presents as a solitary bony lesion. Multifocal ES of the central nervous system is extremely rare, with an incidence ranging from 1.1% to 4.3%. Clinically, ES may mimic osteomyelitis. In this report, we describe the case of an 11-year-old boy who had multiple calvarial, leptomeningeal, spinal and various other bony lesions of ES, which were diagnosed radiologically and histopathologically. To the best of our knowledge, this is the first time that multiple brain, calvarial and spinal lesions of ES in a single patient have been reported in the English-language literature. We discuss possible mechanisms and differential diagnoses for this rare pathology. (C) 2007 Elsevier Ltd. All rights reserved.Öğe Unusual presentation of cervical spinal intramedullary arachnoid cyst in childhood: Case report and review of the literature(Karger, 2007) Guzel, Aslan; Tatli, Mehmet; Yilmaz, Fahri; Bavbek, MuradThe authors report a 7-year-old girl who presented with progressive quadriparesis which had started a month before admission. Magnetic resonance imaging of the spine revealed an intramedullary cystic lesion extending from C-2 to C-4. After performing a C2-5 laminectomy, the cyst was drained and anatomically fenestrated with the subarachnoid space by a 1-cm vertical median myelotomy without using a stent. The histopathological findings revealed arachnoid cyst. In the first month after operation, the neurological deficits disappeared gradually, except for a slight left upper paresis. Cervical spinal intramedullary arachnoid cyst is extremely rare and should be considered in the differential diagnosis of intramedullary cystic lesions in childhood. Recovery is possible after subtotal excision and fenestration of the cyst to allow communication with the subarachnoid space even if neurological deficits are present for a long time. Copyright (c) 2007 S. Karger AG, Basel.
