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Öğe Anticardiolipin antibodies in hemodialysis patients with hepatitis C and their role in fistula failure(Dustri-Verlag Dr Karl Feistle, 2009) Ozmen, S.; Danis, R.; Akin, D.; Batun, S.Background/Aims: Several conflicting results are presently reported regarding raised IgG and IgM-anticardiolipin antibodies (ACA) titers in hemodialysis (HD) patients and their role in vascular access dys-function. We aimed to determine the prevalence of both IgM and IgG-ACA titers and to analyze retrospectively their role in primary and secondary arteriovenous fistula (AVF) failure in a homogeneous group of HD patients with chronic hepatitis C. Methods: This study included 103 adults on maintenance hemodialysis with chronic hepatitis C infection. All participants had blood samples drawn predialysis and after an overnight fast. Analysis included biochemistry, IgG and IgM ACA, Anti-HCV, HBsAg, serum HCV RNA and HCV genotyping. Results: The prevalence of IgG-ACA was 14.6% (15/103). No patient had a positive value of the IgM-ACA test. HCV replication was detected in 52 of 76 patients. The most common HCV genotype was genotype 1 (90%). The percentage of females was higher in ACA(+) group (p = 0.038). There were no significant differences between subjects with and without ACA-IgG regarding other parameters studied. No difference in regard to AVF survival was detected between ACA(+) and ACA(-) groups (p > 0.05). Conclusion: We found no significant differences in primary or secondary AVF failure between patients with elevated and normal ACA. Therefore, we conclude that AVFF may be caused by factors other than ACA in these patients. More prospective studies are needed to confirm this observation.Öğe The corelation between serum VEGF levels and known prognostic risk factors in colorectal carcinoma(Amer Soc Clinical Oncology, 2008) Bestas, R.; Isikdogan, A.; Cil, T.; Batun, S.; Altintas, A.[Abstract Not Available]Öğe The effects of nimopidine on platelet aggregation in severe head injury(Springer-Verlag Wien, 2008) Tatli, M.; Guzel, A.; Kilincer, C.; Batun, S.Background. Severe head injury (SHI) is often associated with traumatic subarachnoid haemorrhage (tSAH), vasospasm, and results in an unfavorable outcome. The aim of this study was to evaluate the effect of nimodipine on platelet aggregation in SHI. Method. This prospective study consisted of 80 patients (53 male, 27 female; ages ranging from 17 years to 65 years, mean: 36.2 years) with severe head injury (Glasgow Coma Score, GCS < 8). All patients received antioedema therapy and prophylactic anticonvulsant. The patients were randomly assigned to either the nimodipine group (2 mg/h continuous infusion for one week) (n = 45) or the control group (n = 35). There were 13 patients with tSAH in the nimodipine group and 10 patients with tSAH in the control group. The platelet aggregation ratio (PAR) was measured on the initial day and the 7(th) day. Higher PAR indicates lower circulating platelet aggregates. Findings. The two groups were well matched for age, sex, mode of injury, neurological status and CT scan findings. In fact, comparison of PAR and GCS in the two treatment groups revealed no difference on the first day. Compared to initial values, the nimodipine group showed a significantly higher PAR value (0.6 +/- 0.1 vs. 0.9 +/- 0.2, p < 0.001) and mean GCS value (7.4 +/- 0.7 vs. 13.7 +/- 1.0, p < 0.001) on the 7(th) day. As a result, on the 7(th) day, the nimodipine group had a significantly higher PAR values (0.7 +/- 0.1 vs. 0.9 +/- 0.2, p < 0.001) and mean GCS (12.3 +/- 1.3 vs. 13.7 +/- 1.0, p < 0.001) as compared to the control group. When the analyses were repeated for the subgroups (the patients with tSAH or contusion) nimodipine showed the same effectiveness. Conclusions. Nimodipine effectively inhibits platelet hyperaggregability in severe head injury patients with or without traumatic subarachnoid haemorrhage. Thus, it may have a potential for use in these patients. However, its effect on long-term outcomes such as death and disability rates and quality of life is still to be determined.Öğe Lymphocyte Subsets and Cytokine Levels in Ascitic Fluid in Patients with Decompensated Liver Cirrhosis with Spontaneous Bacterial Peritonitis(Elsevier Sci Ltd, 2008) Goral, V.; Gil, C. A.; Batun, S.[Abstract Not Available]Öğe Screening survey of beta thalassemia carriers in Diyarbakir province(Blackwell Publishing, 2006) Ekinci, S.; Erdinc, L.; Gunes, K.; Batun, S.; Kaplan, A.; Kale, E.; Canoruc, N.[Abstract Not Available]Öğe Serum IL-2R, IL-6, Ig G, Ig G subgroups (IgG 1, 2, 3, 4) levels in iron deficiency anemia and ?-thalassemia carriers(Blackwell Publishing, 2006) Demir, M.; Canoruc, N.; Batun, S.; Kale, E.; Erdinc, L.; Kaplan, A.[Abstract Not Available]
