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    Effects of extremely low frequency electromagnetic fields on hematologic and immunologic parameters in welders
    (Elsevier Science Inc, 2002) Dasdag, S; Sert, C; Akdag, Z; Batun, S
    Background. Electric are welding is known to cause considerable exposure to extremely low frequency magnetic fields. Although some studies of exposure to magnetic fields and epidemiologic studies have included groups of welders, typically little information is available concerning the hematologic and immunologic effects of ELF electromagnetic fields on welders. Therefore, the aim of the present study is to investigate whether or not extremely low frequency electromagnetic fields (ELF EMF) emitted from electric arc welding affect sonic hematologic and immunologic parameters of welders. Methods. The study was carried out on 16 male welders and 14 healthy males between 20 and 40 years of age from the same geographic area and with similar life styles. The following hematologic and immunologic parameters were measured in both groups: red blood cells (RBC); hemoglobin (Hgb); hematocrit (Hct); platelets (Plt); total white blood cells (WBC); neutrophils; lymphocytes; eosinophils; and CD3, CD4, CD8, and CD4/CD8. Results. Some of the hematologic and immunologic parameters under investigation were similar in both groups. Although T lymphocyte surface antigens, such as levels of CD4 and CD8 were found to be lower in the welders than in the control subjects (p<0.001, p<0.05), the hematocrit levels of the welders were found to be higher than those of the control subjects(p<0.05). However, the differences observed were not clinically significant. ELF electromagnetic field intensities in the welding areas varied between 0.10 and 0.25 mT. Conclusions. These results suggest that ELF electromagnetic fields do not affect the hematologic and immunologic parameters of welders. (C) 2002 IMSS. Published by Elsevier Science Inc.
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    Factor V Leiden mutation in venous thrombosis in southeast Turkey
    (Sage Publications Inc, 2006) Kalkanli, S; Ayyildiz, O; Tiftik, N; Batun, S; Isikdogan, A; Ince, H; Tekes, S
    Venous thrombosis (VT) is a common disease, with an annual incidence in the general population of approximately I per 1,000. Factor V Leiden mutation (G1691A) (FVL) is the most common risk factor in venous thrombosis. The prevalence of FVL for thrombosis varies greatly in different regions of the world. FVL mutation has been identified both by conventional method and fluorescence resonance energy transfer (FRET) with the LightCycler. Sixty-one patients with VT, different in age and sex, were consecutively entered into this study to assess the prevalence of FVL in VT in southeast Turkey. FVL mutation was found in 24.6% (15/61). Fourteen individuals were heterozygous and I homozygous, a rate of 22.9% and 1.6%, respectively. In conclusion, the authors suggest that FVL mutation is common in patients with venous thrombosis in southeast Turkey.
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    Hepatitis C virus in patients with non-Hodgkin's lymphoma in southeastern Anatolia region of Turkey: A prospective case-control study of 119 patients
    (Taylor & Francis Ltd, 2003) Isikdogan, A; Ayyildiz, O; Dursun, M; Tiftik, N; Batun, S; Muftuoglu, E
    Hepatitis C virus (HCV) has been associated with several extrahepatic disorders including mixed cryoglobulinemia (MC), autoimmune thyroiditis, Sjogren's syndrome. Such associations have led to the suggestion that HCV may participate in the development of various immunmediated disorders. Recently, it has been hypothesised that HCV might act as a trigger for the development of monoclonal B-cell disorders such as non-Hodgkin's lymphoma (NHL). Discordant data have been reported in different geographic regions of the world. The aim of this prospective case-control study was to detect the prevalence of HCV in patients with NHL in southeastern Anatolia region of Turkey. In this study, HCV antibody prevalence and cryoglobulinemia were investigated in 119 patients with histologically diagnosed NHL. The control group consisted of 117 patients who visited the outpatient clinic of internal medicine. None of the patients had HCV antibody positive (0%) with the enzyme immunoassay and reverse transcriptase polymerase chain reaction (RT-PCR). One of the control patients had positive HCV antibody (0.9%). Our data does not support the association between HCV infection and NHL in southeastern Anatolia region of Turkey.
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    The importance of CD7 and CD56 antigens in acute leukaemias
    (Wiley, 2004) Tiftik, N; Bolaman, Z; Batun, S; Ayyildiz, O; Isikdogan, A; Kadikoylu, G; Muftuoglu, E
    The prognostic significance of immunophenotypical properties of leukaemic cells is well known. However, the biological and clinical significance of CD7 and CD56 antigen expression in acute leukaemias are not clearly established. In patients with acute leukaemias, we identified CD7 and CD56 expression and analysed their associations with markers expressed early in haemopoietic ontogeny and clinical parameters. Among 22 patients with acute leukaemia [12 acute myeloblastic leukaemia (AML), 10 acute lymphoblastic leukaemia (ALL)], we found CD7 positivity in 15 of 22 patients (68%) and CD56 positivity in four patients (18%). CD7 positivity was observed in seven patients (58%) with AML and in eight patients (80%) with ALL. CD56 positivity was observed in three patients (25%) with AML and one patient (10%) with ALL. Lymphadenopathy was present in five patients and associated with hepatosplenomegaly in three patients with ALL. Splenomegaly and hepatomegaly were present in three patients with AML. Central nervous system involvement was seen in one patient with ALL. Complete remission was achieved in nine patients (41%) (five ALL and four AML). Our data showed that CD7 and CD56 positivity at diagnosis associated with low remission rate and biological aggressiveness in a significant proportion of patients. We suggest the evaluation of CD7 and CD56 in all patients with acute leukaemias at the time of diagnosis in view of poor clinical outcome.
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    Molecular basis of ?-Thalassemia mutations in Diyarbakir in the southeastern region of Turkey
    (Marcel Dekker Inc, 2003) Ince, HH; Ayyildiz, O; Kalkanli, S; Batun, S; Muftuoglu, E
    [Abstract Not Available]
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    Prevalence of factor V Leiden and prothrombin G20210A gene mutation
    (Saudi Med J, 2005) Irdem, A; Devecioglu, C; Batun, S; Soker, M; Sucakli, IA
    Objectives: To determine the prevalence of factor V Leiden (FVL) and prothrombin gene (PG) 20210A mutations in patients who attended the outpatient clinic and do not have a family history of thrombosis. Methods: We researched FVL and PG20210A mutations in 151 outpatients (92 males and 59 females) who attended the Pediatrics Polyclinic, Medical Faculty, Dicle University, Turkey between May 2002 and July 2002. Peripheral venous bloods (2 cc) with ethylenediaminetetraacetic acid were used to isolate DNA by high pure polymerase chain reaction (PCR). Later, by using light-cycler FVL (Roche) and prothrombin mutation detection kit (Roche) and light-cycler equipment, FVL and PG20210A gene mutations were determined from the samples in the glass capillary tubes by PCR specific adaptation. For active protein C (APC) resistance, STA-STACLOT APC-R Detection Kit was used. Expected values were evaluated with STA equipment and using STA-STACLOT APC-R procedure. Results: The prevalence of heterozygote mutations of FVL was 4.6% and PG20210A was 0.7%. The FVL mutation frequency obtained in our study is lower than the other studies in Turkey, but in correlation with the results of the other Caucasian populations throughout the world. Active protein C resistance in patients carrying heterozygote mutation of FVL has been found in low rates. Factor V Leiden and PG20210A were confronted in high prevalences in patients who suffer venous thrombosis (VT). Conclusion: Scanning of FVL and PG20210A gene mutations may be recommended in high risk groups such as relatives of FVL and PG20210A carriers and relatives of patients with VT, and in during pregnancy, the use of oral contraceptives and before surgery. Routine scanning of FVL and PG20210A gene mutations is not recommended in people who do not have risk factors for VT.
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    Prothrombin G20210A gene mutation with LightCycler polymerase chain reaction in venous thrombosis and healthy population in the southeast of Turkey
    (Springer, 2004) Ayyildiz, O; Kalkanli, S; Batun, S; Aybak, M; Isikdogan, A; Tiftik, N; Bolaman, Z
    Venous thrombosis (VT) is a common disease, with an annual incidence in the general population of approximately 1 per 1000. The prevalence of genetic risk factors for thrombosis varies greatly in different parts of the world. Prothrombin G20210A (PT G20210A) gene mutation has been recently identified as a common risk factor in venous thrombosis. Sixty-one patients with VT, differing in age and sex, and 340 healthy subjects were consecutively enrolled into our study to determine the prevalence of PT G20210A in VT and in the healthy population of the southeast of Turkey. The mutation was identified with fluorescence resonance energy transfer (FRET) with the LightCycler polymerase chain reaction. The PT G20210A mutation was found to be 6.5% (4/61) in the VT group and 1.2% (4/340) in the healthy group (P = 0.021). Three patients with VT had a heterozygous PT G20210A mutation, and the other patient with VT had both Factor V Leiden and PT G20210A mutations. We showed that this method may be used safely for detection of the PT G20210A gene mutation, and the prevalence of PT G20210A mutation is significantly higher in patients with VT than in the healthy population in the southeast of Turkey.
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    Serum levels of carnitine, apolipoprotein A I, and apolipoprotein B in children with nephrotic proteinuria
    (Springer Verlag, 1996) Bircan, Z; Kaplan, A; Soker, M; Batun, S; Sahin, A; Soran, M
    [Abstract Not Available]
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    Sialic acid in childhood renal diseases: Correlation with clinical and laboratory indices
    (Blackwell Science, 1998) Bircan, Z; Batun, S; Kervancioglu, M; Soran, M; Kaplan, A; Onur, H; Demir, F
    There are many kinds of glycoproteins that have sialic acid residues and it has been reported that these are elevated in some renal diseases and their significance in the pathogenesis of several renal diseases has been investigated. In the present study the serum and urine levels of sialic acid were measured in healthy controls and in children with either poststreptococcal acute glomerulonephritis (PSAGN) or minimal change nephrotic syndrome (MCNS) to test if there is any correlation with clinical and laboratory indices. In PSAGN and MCNS patients the serum and urine sialic acid concentrations at onset and relapse were significantly different from healthy controls (Mann-Whitney U-test P < 0.005). There was not a significant correlation between the clinical severity, serum creatinine and complement C-3 levels and serum sialic acid concentrations in PSAGN patients. Also there was not a significant correlation between edema, serum albumin, IgG, transferrin, alpha-1-antitrypsin and serum sialic acid concentrations in MCNS patients. Although high serum and urine sialic acid levels were found in both PSAGN and MCNS patients, it does not have any clinical significance nor is it important as a diagnostic or prognostic marker.