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    Can Mean Platelet Volume be a New Risk Factor in Portal Venous Thrombosis?
    (Sage Publications Inc, 2013) Aliosmanoglu, Ibrahim; Gul, Mesut; Oguz, Abdullah; Basol, Omer; Uslukaya, Omer; Keles, Celalettin
    Background: The aim of this study was to discuss the possibility of mean platelet volume (MPV) being a new risk factor in the etiology of portal venous thrombosis (PVT). Methods: Study participants were categorized into 2 different groups: group I, control group (n = 35) and group II, PVT group (n = 34). Demographic data and MPV values were recorded retrospectively. Results: No differences were determined between the 2 groups regarding hypertension, diabetes mellitus, and smoking (P > .05). The average hemoglobin levels were 10.8 +/- 2.1 in group II and 14.0 +/- 1.7 in group I (P < .001). Although the MPV levels of group II patients were 8.2 +/- 0.52, the average level in group I was determined as 7.8 +/- 0.62 (P = .012). In the performed receiver-operating characteristic (ROC) analysis, the cutoff value for patients with PVT for MPV was determined as 7.9 (area under curve: 0.674), sensitivity as 70.6%, and specificity as 65.7% (P = .013). Conclusion: The current study shows that MPV is significantly higher in patients with PVT than in the control group.
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    The effect of platelet-albumin ratio on mortality and morbidity in peptic ulcer perforation
    (Lippincott Williams & Wilkins, 2022) Bilge, Huseyin; Basol, Omer
    Background: The aim of our study was to investigate the prognostic role of platelet/albumin ratio in patients treated under emergency conditions for peptic ulcer perforation (PUP). Methods: A retrospective study involving emergency patients who were operated for PUP was carried out. The patients were divided into 2 groups: PUP patients who died after surgical treatment (PUP-M) and PUP patients who survived after surgical treatment (PUP-S). The laboratory values of the patients were compared statistically. A P value of Results: This cohort study consisted of 171 patients treated between June 2013 and December 2019. The mean age of the patients was 46.3 +/- 20.5 years; and 33 (19.3%) patients were women. The age (P <= .001), platelet/lymphocyte ratio (P = .02), lactic dehydrogenase to albumin ratio (P <= .001), and platelet/albumin ratio (PAR; P <= .001) values were high and lymphocyte count was low (P = .006) in the PUP-M group. A positive correlation was determined between length of stay in hospital and age (P <= .001), lactic dehydrogenase/albumin ratio (P <= .001), platelet count (P = .044), and PAR (P <= .001). A substantial negative correlation was determined between length of stay in hospital and albumin count (P <= .001). Conclusions: We determined a high preoperative PAR level in PUP patients who had undergone surgery as a negative prognostic parameter. PAR is a candidate biomarker for clinical practice.
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    The Effective Factors on Morbidity Due to Penetrating Small Intestine Injuries
    (Aves, 2012) Onder, Akin; Kapan, Murat; Basol, Omer; Boyuk, Abdullah; Gumus, Metehan; Gul, Mesut; Girgin, Sadullah
    Objective: In this study, we aimed to investigate the effective factors on morbidity due to small intestine penetrating injuries. Material and Methods: Between January 2006 and December 2010, 114 patients who underwent surgery due to penetrating small intestine injuries were retrospectively reviewed. Results: The mean age was 32.8 +/- 12.3years (15-77), and there were 96 patients, (84.2%) male and 18 (15.8%) female patients. The most common etiologic cause was gun-shot injuries (66.7%).Fifty-one (44.7%) patients had isolated small intestine injuries and 63 (55.3%) had small intestine and additional organ injuries. Colon was the most common additional organ injured (66.7%) Most commonly, 68 (59.7%) patients underwent primary suture. T Postoperative morbidity occurred in 30 patients (25%) and the most common complication was wound infection. The morbidity was significantly higher in the patients with small intestine and additional organ injuries (p=0.006). The morbidity was higher in patients who exhibited signs of peritonitis (p=0.048) and had colonic injuries (p=0.002). The number of blood transfusions was effective in mortality (p<0.001). The mean length of hospital stay was 6.9 +/- 2.9 (1-21) days, significantly longer in the patients who developed morbidity (p=0.002). Seven (6.1%) patients died due to hemorrhage in 6 patients and anastomotic leakage in 1 patient. Conclusion: Small intestine injuries significantly increase the postoperative morbidiy when accompanied by additional intraabdominal organ injuries, especially the colon.
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    Investigation of the effects of sildenafil on liver and remote organ in hepatic ischemia-reperfusion damage
    (Wolters Kluwer Medknow Publications, 2020) Cetin, Erman; Oguz, Abdullah; Basol, Omer; Bilge, Huseyin
    Introduction The aim of this study was to demonstrate whether sildenafil is effective in minimizing and/or eliminating hepatic ischemia/reperfusion injury effects. For this purpose, the authors experimentally performed biochemical and histopathological examinations of the included rats using the hepatic ischemia/reperfusion model. Materials and methods The authors used 40 animals, with 10 rats in each group, in this study. Ischemia was applied 30-45min with the hepatoduodenal ligament clamping, and then reperfusion is started. The rats were grouped as follows: the first group, only laparotomy; the second group, laparotomy and sildenafil; the third group, hepatic ischemia-reperfusion; and the fourth group, hepatic ischemia-reperfusion and sildenafil. During experimental studies, sildenafil capsules were opened, and appropriate dose required for animals had been created with the weighing scales. Then, the powder was diluted with saline. The authors gave sildenafil through oral gavage 15 minutes before the ischemia. 60min after starting the experiment in 1-2 groups and 30min after beginning reperfusion in 3-4 groups (60min after beginning the experiment in all groups), blood was taken from the animals for biochemical analysis, and the animals were sacrificed. Simultaneously liver, lung, and kidney tissues were removed for biochemical and histopathological examination. Results Based on plasma evaluation, total antioxidant status was lower (P=0.0274) in ischemia/reperfusion group compared with ischemia/reperfusion+sildenafil group. However, there was no difference between the groups regarding total oxidant status values (P=0.0274). When comparing total antioxidant status and oxidative stress index in liver tissue, a statistically significant difference was observed between groups (P=0.012766 and P=0.004081), but on comparing histopathological scores, there was no difference between groups (P=0.1244). Conclusion Sildenafil partly reduced the effects of hepatic ischemia-reperfusion injury on the liver and distant organs, although this difference was not statistically significant.
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    Predictive factors affecting mortality in relaparotomies
    (E-Century Publishing Corp, 2016) Basol, Omer; Pulat, Huseyin; Zihni, Ismail; Damar, Sedat; Ozcelik, Kazim Caglar; Eken, Huseyin; Karakose, Oktay
    Aim: The present study was aimed to analyze the predictive factors for the mortality of relaparatomies. Materials and method: The retrospective study included 236 patients who underwent abdominal surgery and at least one subsequent relaparatomy at Dicle University School of Medicine Department of General Surgery between January 2000 and December 2011. The evaluations included age, gender, accompanying systemic diseases, procedure used in the primary surgery and its condition (emergency/elective), total amount of blood transfusion since the primary surgery, length of time between the primary surgery and relaparatomy, date of the primary surgery, preoperative parameters (albumin, platelet, hemoglobin, leukocyte, and MPV), Glasgow coma score, length of hospital stay, length of stay in intensive care unit, and presence of shock. Results: The patients comprised 165 (69.9%) men and 71 (30.1%) women. The mean age was 55.5 +/- 17.22 years (15-89). Early stage relaparatomy (i.e. within the 21 days following the primary surgery) was performed in 231 (97.8%) patients while 5 (2.2%) patients received it in the late stage (i.e. after the 21st day). Mortality rate was 13.8% (32/231) in the early stage and 80.0% (4/5) in the late stage. The patients over 50 years old had a mortality rate of 66.6% (24/36) and the ones below 50 years old had 6.0% (12/200). It can be concluded that the need for a relaparatomy and the risk of mortality could be reduced by a well-arranged primary surgery and efficient time management in handling the postoperative complications. Nevertheless, if needed, relaparatomy could be life-saving when performed at the correct time. Conclusion: The decision whether and when to perform a relaparatomy, preoperative preparation, number of laparatomies, amount of blood transfusion, and the length of period since the primary surgery are important factors for the mortality.
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    Rectus Sheath Hematoma-a Hitherto Less Described Entity
    (Springer India, 2021) Basol, Omer; Bilge, Huseyin; Kirsan, Mehmet Ali; Yaman, Gizem
    Rectus sheath hematoma is a rare condition that is manifested by abdominal wall pain and stiffness in the abdominal wall. It is usually a result of the rupture of the epigastric vessels or rectus muscle into the lower part of the umbilical region. Surgical intervention is rarely required due to diagnosis and uncontrollable growth. Twenty-two patients who were diagnosed and followed up with rectus sheath hematoma between January 2010 and January 2020 in Dicle University Medical Faculty, Clinic of General Surgery, were retrospectively reviewed for demographic features, clinical and radiological findings, and length of hospital stay. The most common complaints of patients with rectus sheath hematoma were abdominal wall pain, swelling, ecchymosis, and mass on the abdominal wall. The average age of the patients was 63 (22-78) years. Twenty of the patients were women and 2 of them were men. None of the patients had a history of trauma, and all were using anticoagulant drugs. In radiological imaging, types of rectus sheath hematoma were type 1 in twelve patients, type 2 in seven, and type 3 in three. Firstly, anticoagulant medications used by patients were discontinued. Then, all patients, except two who were undertaken surgery, were treated conservatively. The reason for the surgery was rapid and widespread growth of hematoma. The average length of hospital stay was 7 (6-13) days. At the end of the first month after diagnosis and treatment, computed tomography revealed that the mass disappeared in patients with type 1 rectus sheath hematoma, while the other patients had a marked reduction in mass size. In patients with an abdominal wall pain, anemia, a mass/ecchymosis on anterior abdominal wall, and history of anticoagulant medication, rectus sheath hematoma should be considered in the differential diagnosis. Early diagnosis of rectus sheath hematoma ensures the prevention of unnecessary surgical interventions and determines the success of conservative treatment.
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    Risk Factors Effecting Mortality in Acute Mesenteric Ischemia and Mortality Rates: A Single Center Experience
    (Int College Of Surgeons, 2013) Aliosmanoglu, Ibrahim; Gul, Mesut; Kapan, Murat; Arikanoglu, Zulfu; Taskesen, Fatih; Basol, Omer; Aldemir, Mustafa
    The objective of this study is to discuss the effective factors on morbidity and mortality in patients who were operated on for acute mesenteric ischemia. Between 2006 and 2011, 95 patients, who underwent emergent surgery for acute mesenteric ischemia, were analyzed retrospectively. The study group consisted of 56 men (58.9%) and 39 women (41.1%), with an average age of 68.4 +/- 14.4 years. Elapsed time between the onset of the symptoms and the surgical operation was less than 24 hours in 47 (49.5%) cases, and more than 24 hours in 48 cases (50.5%) (P < 0.001). Although all of the patients had intestinal necroses, colon involvement was seen in 38 patients, and mortality was higher in this group of patients (P M 0.001). Mortality rate was 42.1%. This was higher in older patients, those with increased leukocyte levels, increased elapsed time to laparotomy, and when the colon was involved.