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    The Biochemical and Histologic Effects of Adnexal Torsion and Early Surgical Intervention to Unwind Detorsion on Ovarian Reserve: An Experimental Study
    (Sage Publications Inc, 2013) Ozler, Ali; Turgut, Abdulkadir; Soydinc, Hatice Ender; Sak, Muhammet Erdal; Evsen, Mehmet Siddik; Alabalik, Ulas; Basarali, Mustafa Kemal
    Objective: The aim of the present study was to determine to what extent ovarian reserves are affected by ischemia-reperfusion injury, evaluating the number of growing follicles and the serum levels of the ovarian hormones. Study Design: Thirty female fertile adult Wistar albino rats, weighing 200 to 220 g, were previously numbered to randomization, and then randomly divided into 3 equal groups (n = 10): sham, torsion, and detorsion groups. In torsion and detorsion groups, bilateral adnexal torsion (3-hour ischemia) was carried out. Bilateral adnexal detorsion (3-hour reperfusion) was performed in the detorsion group. Results: The mean number of preantral and small antral follicles in detorsion group were lower than those of the sham group (P < .01). After torsion, anti-Mullerian hormone (AMH), estradiol, and inhibin B levels decreased significantly compared to the preoperative and postoperative periods (P = .003, P = .032, and P = .014, respectively). In detorsion group, only AMH levels were found to decrease significantly following the 3-hour ischemia and 3-hour reperfusion (P < .05). Conclusion: After adnexal torsion, a significant decrease in ovarian reserve has been detected for the first time in this study. Additionally, the results of this study suggest that conservative surgery alone is insufficient to protect ovarian reserve.
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    A comparison of the effects of aggressive dose and conventional dose atorvastatin applications on IL-6 and NO levels in patients with acute myocardial infarction
    (Academic Journals, 2011) Basarali, Mustafa Kemal; Buyukbas, Sadik; Yazar, Hayrullah; Kiyici, Aysel; Kayrak, Mehmet; Ulgen, Siddik
    High dose statin medication in acute coronary syndrome cases is a therapy which lowers mortality and morbidity rates. Interleukin-6 (IL-6) is produced in higher amounts in acute myocardial infarction (MI) and facilitates myocardial damage. However, secretion of nitric oxide (NO) is depleted. We aimed to compare the effects of conventional dose (10-40 mg/day) and aggressive dose (80 mg/day) atorvastatin medications on IL-6 and NO levels in patients with primary percutaneous transluminal coronary angioplasty (PTCA) intervention after acute MI. 50 patients (8 females, 42 males) with the diagnosis of acute MI with ST segment elevation enrolled to the study. Primary PTCA intervention was performed on these patients and consequently either conventional dose (10 to 40 mg/day) or aggressive dose (80 mg/day) atorvastatin medications were given to the patients. Three months later, plasma IL-6 and NO levels were determined and alterations in the groups were evaluated. IL-6 levels decreased from 24.34 +/- 12.04 to 11.40 +/- 5.79 pg/ml and from 29.62 +/- 17.38 to 12.51 +/- 8.95 pg/ml in conventional dose and aggressive dose regimens respectively (p<0.001). However, NO concentrations increased from 22.90 +/- 8.24 to 31.70 +/- 7.56 mu M in conventional dose and from 19.37 +/- 5.60 mu M to 34.15 +/- 9.60 mu M in aggressive dose groups (p < 0.001). The effects of aggressive dose atorvastatin medication on IL-6 and NO levels were similar to conventional dose application in cases with ST segment elevation acute MI.
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    Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion
    (Wolters Kluwer Medknow Publications, 2011) Boyuk, Abdullah; Onder, Akin; Kapan, Murat; Gumus, Metehan; Firat, Ugur; Basarali, Mustafa Kemal; Alp, Harun
    Background: The aim of this study was to investigate the possible protective role of antioxidant treatment with ellagic acid (EA) on lung injury after intestinal ischemia-reperfusion (I/R) injury using biochemical and histopatological approaches. Materials and Methods: Forty rats were divided into four groups as control, control + EA, I/R, and I/R + EA. The control and control + EA groups were also anesthetized and subjected to laparotomy, but without clamp application. The control + EA and I/R + EA groups were given EA (85 mg/kg) orally prior to experiment. The I/R and I/R + EA groups underwent 30 minutes of intestinal ischemia and 1 hour of reperfusion. In all groups, serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels were determined. TAC, total oxidative status (TOS), and oxidative stress index (OSI) in lung tissue were measured. Lung tissue histopathology was also evaluated by light microscopy. Results: TAC levels were higher in control, EA, and I/R + EA groups while TOS, OSI, and MDA levels were lower in these groups compared with I/R group. Serum MDA levels were significantly higher in I/R + EA group than that of control group. Lung tissue TAC levels were lower in I/R + EA group while OSI values were higher in that groups compared with EA group. Histological tissue damage was milder in the EA treatment group than in the I/R group. Conclusion: These results suggest that EA treatment protected the rats lung tissue against intestinal I/R injury.
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    Evaluation of the Protective Effects of CoQ10 on Ovarian I/R Injury: An Experimental Study
    (Karger, 2013) Ozler, Ali; Turgut, Abdulkadir; Goruk, Neval Yaman; Alabalik, Ulas; Basarali, Mustafa Kemal; Akdemir, Fatih
    Background: The aim of this study was to investigate the protective effects of coenzyme Q(10) (CoQ(10)) on ovarian ischemia/reperfusion injury in an experimental rat adnexal torsion model. Methods: 48 female adult Wistar albino rats, weighing 220-250 g, were randomly equally divided into six groups (n = 8): sham, torsion, detorsion, sham+CoQ(10), torsion+CoQ(10), and detorsion+CoQ(10) groups. Bilateral adnexal torsion was performed for 3 h in all groups, except the sham and sham+CoQ(10) groups. Bilateral adnexal detorsion was performed on the detorsion and detorsion+CoQ(10) groups. CoQ(10) was injected intraperitoneally 30 min before the sham operation, torsion, and detorsion. Results: The torsion and detorsion groups had significantly higher histologic evaluation scores, as well as higher MDA levels, TOS values, and oxidative stress index values than the sham group. A strong correlation between total histologic evaluation scores for ischemia/reperfusion injury and the oxidative stress index was found. The mean oxidant marker levels and histopathologic scores for the ovarian tissue significantly decreased after using CoQ(10), which is a potent antioxidant. Conclusions: Conservative surgery (detorsion) was found to provide inadequate protection to ovarian tissue. The results of this study suggest that CoQ(10) could be useful for the protection of ovarian tissue before conservative surgery. (C) 2013 S. Karger AG, Basel
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    THE RELATIONSHIP BETWEEN TRACE ELEMENTS AND CERULOPLASMIN WITH SEVERITY OF FASCIOLIASIS PATIENTS
    (Carbone Editore, 2013) Basarali, Mustafa Kemal; Kaplan, Ibrahim; Cicek, Mutalip; Cakir, Fatih
    The aim of our study is to evaluate the relationship between trace elements, as zinc (Zn) and copper (Cu), and acute phase reactant ceruloplasmin (CP) levels during fascioliasis hepatic infection. 45 patients with fascioliasis and 38 healthy controls were enrolled in the study. Fascioliasis was diagnosed with ELISA IgG, stool examination and radiologic imaging. Number of females and males were determined as 34111 and 3018 in patient and control groups respectively. Mean age was 38.1 +/- 11.7 and 358 +/- 16.9 years in patient and control groups, respectively. Blood samples were collected to determine plasma Zn, Cu, and CP levels. As a result of the study serum Cu (from 1.4 to 1.8) and CP (from 26.7 to 33.4) levels were rised in while Zn (from 1.1 to 1.9) level was decreased in patient group. We determinated significant correlation (r: 0.781) of fasciola titers with ceruloplasmine that increased by acute phase in the patients with fascioliasis. In conclusion, an high correlation between CP and Cu levels in patients suffering from fascioliasis can be noted. On the other hand, low Zn levels, especially in endemic areas of disease, suggested that Zn can be given in addition to medical treatment, or as a dietary supplement. This situation may lead the way in terms of increasing the efficiency of treatment of fascioliasis.