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  • Küçük Resim
    Öğe
    Psödohipoparatiroidi Tip 1A: Olgu sunumu
    (Dicle Üniversitesi Tıp Fakültesi, 2017) Güven, Mehmet; Pekkolay, Zafer; Soylu, Hikmet; Balsak, Belma Özlem Tural; Tuzcu, Alpaslan Kemal
    Psödohipoparatiroidizm (PHPT); hedef organın parathormona (PTH) yanıt vermediği kalıtımsal bir bozukluktur. Biyokimyasal olarak; hipokalsemi, hiperfosfatemi ve PTH yüksekliği ile karakterizedir. PTH uygulamasına verilen yanıt belirgin derecede düşüktür. Tip 1A, biyokimyasal özelliklere ek olarak Albright herediter osteodistrofisi (AHO) olarak bilinen karakteristik somatik bir fenotipe de sahiptir. Bu fenotipin, kısa boy, yuvarlak yüz, frontal bombelik, brakidaktili, obezite özelikleri bulunmaktadır. Burada biz, hipokalsemi ve Albright herediter osteodistrofisi tanısı koyduğumuz; kalsiyum, aktif D vitamini ile tedavi ettiğimiz olgumuzu sunduk.
  • Küçük Resim
    Öğe
    Testicular adrenal rest tumor
    (Turkiye Klinikleri, 2018) Balsak, Belma Özlem Tural; Pekkolay, Zafer; Güven, Mehmet; Tuzcu, Alpaslan Kemal
    Purpose: Testicular Adrenal Rest Tumor (TART) is a condition that is seen in men with congenital adrenal hyperplasia and particularly in uncontrolled cases. Its pathogenesis is not certain, but TART is believed to be derived from ectopic adrenal cortex remnants in the testis or from reprogrammed Leydig stem cells, that differentiate and grow under the effect of chronically elevated ACTH. Pressure in the testis increases due to the mass effect, and it prevents sperm exit, It presents with bilateral testicular mass and infertility. Case Report: Bilateral testicular mass was detected in a 28-year-old male patient on scrotal ultrasonography who had referred for infertility 1.5 months earlier. Bilateral orchiectomy was suggested to the patient with a presumed testicular tumor. There were hypervascularized solid lesions in right (18 mm), and left testes (15 mm) in his scrotal USG. In MRI, bilateral testicular masses were detected (25x33 mm in right testicle and 16x22mm in the left). The patient who did not accept the operation was directed to our endocrine polyclinic with the complaints of testicular mass and azoospermia. His laboratory test results were as following: LH: 0.1mIU/ml (1.7-8.6), FSH: 0.1 mIU/ml (1.5-12.4), T, Testesteron: 6.7 ng/ml (2.18-9), Prolaktin: 18 ng/ml (4.04-15.2), TSH: 3.19 (0.270-4.2), T4: 16.7 pmol/L (12-22), Kortizol: 3.5 µg/dL, ACTH:153 pg/mL, 17 Hidroksiprogesteron: 48 ng/mL, BHCG:0.1 mIU/ml (<5.3), AFP: 0.55 IU/ml (0.5-5.5), Synacten Test was conducted, Kortizol 30.dk was 4.9. 60.dk 4.9. 90.dk 4.9. 120.dk 5.4. 17-hydroxyprogesterone level at 30.dk was 39.7. 60.dk 36.5. 90.dk 28.8. 120.dk 25. No sperm cells were detected in the spermiyogram. Congenital Adrenal Hyperplasia and Testicular Adrenal Rest tumor were diagnosed in this patient. Prednisolone 5 mg started. Genetic analysis revealed mutation in 21 hydroxylase gene. In his follow-up, 7.5 million sperm were detected in the spermiogram and bilateral masses with slight shrinkage. Conclusions: Adults with congenital adrenal hyperplasia (CAH) may refer with infertility and bilateral testicular adrenal mass. The patient should be well assessed; surgery should not be performed if not necessary. Fertility is possible by starting corticosteroid therapy and adjusting the optimal dose.
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    Öğe
    TİROTOKSİKOZUN NADİR BİR NEDENİ: MOL HİDATİFORM
    (2017) Soylu, Hikmet; Tuzcu, Alpaslan Kemal; Pekkolay, Zafer; Fındık, Fatih Mehmet; Balsak, Belma Özlem Tural
    1Dicle Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Endokrinoloji Bilim Dalı, DİYARBAKIR 2 Dicle Üniversitesi Tıp Fakültesi, Kadın Doğum Hastalıkları Anabilim Dalı, DİYARBAKIR