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    Effects of chlorhexidine/benzydamine mouth spray on pain and quality of life in acute viral pharyngitis: A prospective, randomized, double-blind, placebo-controlled, multicenter study
    (Sage Publications Inc, 2010) Cingi, Cemal; Songu, Murat; Ural, Ahmet; Yildirim, Muzeyyen; Erdogmus, Nagehan; Bal, Cengiz
    We conducted a prospective, randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy of chlorhexidine gluconate/benzydamine HCl mouth spray for reducing pain and improving quality of life in patients with acute viral pharyngitis. Prior to treatment, patients rated the intensity of their pain on a visual analog scale and evaluated their quality of life on the 36-Item Short-Form Health Survey. Patients were then randomized to receive either paracetamol (acetaminophen) plus chlorhexidine/benzydamine or paracetamol plus placebo for 7 days. On days 3 and 7 of treatment, the participants again rated the intensity of their pain, and on day 7, they again rated their quality of life. A total of 164 patients were evaluable at study's end-80 in the chlorhexidine/benzydamine group and 84 in the control group. A comparison of self-evaluations revealed that the active treatment group reported less pain on both day 3 (p < 0.001) and day 7 (p = 0.002). Likewise, the chlorhexidine/benzydamine group reported a significantly better quality of life on day 7 (p < 0.001). Chlorhexidine/benzydamine was well tolerated, and no serious adverse events were observed.
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    The Score for allergic rhinitis study in Turkey, 2020
    (Dergipark Akad, 2021) Cingi, Cemal; Muluk, Nuray Bayar; Susaman, Nihat; Küçükcan, Nagehan; Kar, Murat; Altıntaş, Mustafa; Altın, Fazilet; Eroğlu, Sinan; Kef, Kemal; İpçi, Kağan; Güven, Selis Gülseven; Dizdar, Senem Kurt; Çayır, Serkan; Salcan, İsmail; Korkmaz, Müge Özçelik; Yılmaz, Aslı Şahin; Topuz, Bülent; Başak, Sema; Ural, Ahmet; Çobanoglu, Bengü Yaldız; Erkan, Alper Nabi; Oğhan, Fatih; Eskiizmir, Görkem; Çakır, Burak Ömür; Coşkun, Berna Uslu; Kara, Cüneyt Orhan; Gültekin, Erdoğan; Üçüncü, Harun; Selçuk, Adin; Altuntaş, Emine Elif; Durmuş, Kasım; Özlügedik, Samet; Toros, Sema Zer; Karameşe, Özgür; Bayındır, Tuba; Baylan, Müzeyyen Yıldırım; İynen, İsmail; Yılmaz, Orhan; Yılmaz, Nihat; Avcı, Deniz; Aysel, Abdulhalim; Bal, Cengiz; Başer, Serdar; Bozkurt, Ziya; Çatlı, Tolgahan; Çetinkaya, Erdem Atalay; Öner, Fatih; Coşkun, Zerrin Özergin; Dizdar, Denizhan; Eksi, Erkan; Gümüşlü, Bekir Can; Kaplan, Aşkın Keskin; Kınar, Abdullah; Parıldar, Hülya; Resuli, Ali Sayed; Köroğlu, Erdem; Yazıcı, Demet; Kurt, Yücel; Dilber, Muhammet; Çukurova, İbrahim; Annesi-Maesano, Isabella
    Objective: This study aimed to determine how prevalent allergic rhinitis (AR) is in Turkey and to compare the current prevalence with the figures obtained 10 years earlier. Methods: This study included 9,017 participants. The minimum number of participants required from each center was determined via a stratified sampling technique according to regional demographic characteristics as ascertained from the last census. For each region, both men and women were administered the score for allergic rhinitis (SFAR) questionnaire and a score for each participant was calculated based on the responses supplied. Results: A total of 9,017 individuals (55.3% men and 44.7% women) took part in this study. Of these, 94.4% were urban residents and 5.6% lived in a rural setting. Of the men, 38.5% self-reported as suffering from AR. The corresponding figure in women was 40.5%. The overall prevalence of AR, as deduced on the basis of the SFAR, was found to be 36.7%. Comparing the prevalence in different regions, we found that AR was the least prevalent in the Black Sea region with a frequency of 35.8%. The highest prevalence was in the Mediterranean region, where the prevalence was 37.7%. There was no statistical significance in the apparent differences in prevalence between different geographical regions. Despite this, however, there was a clear increase in the frequency of AR over the preceding decade. This increase was most pronounced in the South-Eastern Anatolian region, where the frequency rose from 21.0% to 36.9%. Conclusion: Our results indicate that there has been a marked increase in the prevalence of AR in every region in Turkey over the last 10 years. This could be related to living conditions in urban environments. Alterations in lifestyle, urban living, air pollution causing impairments in immune defense mechanisms, and other aspects of modern lifestyles may account for the increase in AR in Turkey.
  • Küçük Resim
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    Seawater gel in allergic rhinitis: Entrapment effect and mucociliary clearance compared with saline
    (2010) Cingi, Cemal; Ünlü, Halis H.; Songu, Murat; Yalçın, Şinasi; Topçu, İsmail; Çaklı, Hamdi; Bal, Cengiz
    Objective: We performed a prospective study to investigate the the efficacy of seawater gel in reducing symptoms in patients with mild allergic rhinitis. We also aimed to investigate the impact of nasal irrigation on mucociliary clearance with seawater gel compared with saline in this patient group. Methods: The study was performed in 100 consecutive adult individuals with a history of allergic rhinitis that was not controlled by anti-allergic drugs. Patients were assigned to receive seawater gel nasal spray for 10 days. The efficacy of treatment was assessed by means of total nasal symptom score and clinical findings. Results: A statistically significant difference was found between scores of ‘nasal discharge, nasal obstruction, sneezing, nasal itching—before and after treatment (p < 0.001). Clinical findings evaluation revealed a statistically significant decrease in lower turbinate colour rating and turbinate congestion at the end of treatment (p< 0.001). Saccharin transit time decreased from baseline in the seawater trials by 12% compared with a 4% decrease for saline. The difference between the percent changes was statistically significant (t = 2.177; p < 0.05). Conclusions: The present study provides evidence that a four times daily regimen of seawater gel can be an adjunctive therapy in the patient with allergic rhinitis.