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Öğe The Demonstration of Changes in Bulbar Conjunctiva Surface Epithelium in the Psoriatic Patients Treated With PUVA(Amer Soc Contemporary Medicine Surgery & Ophthalmology, 2008) Soker, Sevda; Nergiz, Yusuf; Cakmak, Sevin; Bahceci, Selen; Aytekin, SemaWe investigated the effects of disease itself and PUVA treatment on surface epithelium of conjunctiva in psoriatic patients (PP) before PUVA and after PUVA therapy and in 32 healthy volunteers. Squamous metaplasia was detected in PP both before and after PUVA therapy. We concluded that PUVA treatment applied together with preventive measures, would lead to less severe ocular side effects.Öğe An Embryological Cause of Primer Hypothyroidism, Lingual Thyroid(Galenos Yayincilik, 2006) Arikan, Senay; Gokalp, Deniz; Tuzcu, Alpaslan; Bahceci, Mithat; Bahceci, SelenLingual thyroid is a rare developmental thyroid abnormality usually affecting females. It is often found in the region of the foramen caecum as a lingual thyroid at the base of the tongue in patients whose gland fails to descend. A 16-year-old female patient with severe hypothyroidism applied to our outpateint clinic. She was complaining from growth retardation, primary amenorrhea, weakness, decreases of school performance and short stature. No thyroid tissue was seen at the usual site with ultrasonography. Scintigrapy with 99mTC pertechnetate showed an ectopic functioning thyroid in the lingual area. CT scan showed a mass in the base of lingular region. The thyroid profile implied severe hypothroidism (free T3: 0,142 ng/ dl, free T4: 0,741 ng/dl, and TSH: 100 mu IU/ml). Patient was accepted as primary hypothyrodism due to ectopic thyroid tissue (lingual thyroid) and substitution treatment with L-thyroxine was started at the dose of 2-3 mu gr/kg. Surgical treatment did not consider because of patient was asymptomatic in terms of pressure. As a result we reported a rare cause of primary hypothyroidism due to ectopic thyroid gland (lingual) in a young female patient.Öğe Evaluation of effects of memantine on cerebral ischemia in rats(Riyadh Armed Forces Hospital, 2008) Aluclu, Mehmet U.; Arslan, Seyfi; Acar, Abdullah; Guzel, Asian; Bahceci, Selen; Yaldiz, MehmetObjective: To evaluate the effects of memantine on infarct size in cerebral ischemia and on neurological outcome after temporary middle cerebral artery occlusion (MCAO) and reperfusion in rats. Methods: In this study, performed between 2002-2004 in Dicle University School of Medicine, Diyarbakir, Turkey, 30 adult Sprague-Dawley rats were used. Cerebral ischemia was constituted by the intraluminal filament method with a 4-0 nylon suture. Reperfusion was started after 2 hours of MCAO. The rats were randomly divided into 2 groups as control and memantine. Saline 0.9% (0-5 ml/kg) and memantine (30 mg/kg) were administered via nasogastric intubations. Three coronal slices of 2 mm thickness were obtained from cerebrum, cerebellum, and brain stem, and were stained with a 2% solution of triphenyltetrazolium chloride. Transparent sheets were placed over each section and the areas of the brain and infarct were measured. Results: Forty-five slices from each group (total 90) were obtained. Percent of ischemic area (%) in cerebrum, cerebellum, and brain stem level in memantine was lower than those of the control group (p < 0.0001). In addition, we determined an improvement in neurological score at 24th and 72nd hours in the rats that have been given memantine. The memantine group showed significantly better recovery than the control group (p < 0.0001). Conclusions: We concluded that memantine may decrease ischemic area in experimental cerebral ischemia in rats and it seems that memantine may be beneficial in cerebral ischemia.Öğe Evaluation of erythroprotein effects on cerebral ischemia in rats(Maghira & Maas Publications, 2007) Aluclu, Mehmet Ufuk; Acar, Abdullah; Guzel, Aslan; Bahceci, Selen; Yaldiz, MehmetObjective: Majority of severe disabilities in adults are caused by stroke. The aim of our study is to learn the effects of erythropoietin (EP), on infarct size in cerebral ischemia and to determine neurological behavioral scores and histopathological evaluation. Material & Methods: In this study 30 adult Sprague-Dawney rats were used. Cerebral ischemia was constituted by intraluminal filament method with a 4-0- nylon suture. Reperfusion was started after two hours of middle cerebral artery occlusion. The rats were randomly divided into two groups as follow: control and EPO groups. Saline 0.9% (0.5 ml/kg) and EPO (5000 U/kg) was administered intraperitoneally in the groups. Three coronal slices in two millimeters thickness were obtained from cerebrum, cerebellum and brain stem, and were stained with a 2% solution of triphenyltetrazolium chloride. Transparent sheets were placed over each section and the areas of the brain and infarct were measured. The neurological scores were determined at 24(th), 48(th) and 72(nd) hours after reperfusion. Results: Percent of ischemic area (%) in cerebrum, cerebellum and brain stem level in EPO groups were less than those of control group (p<0.0001). In addition, we determined that EPO group was better than controls of neurologic score and histopatologically after cerebral ischemia. Conclusions: We concluded that EPO may decrease ischemic area in experimental cerebral ischemia in rats and it seems that EPO may be beneficial.Öğe Late Histopathological Features of Testis Tissue in a Patient With Male Pseudohermaphroditism Due to Leydig Cell Aplasia(Galenos Yayincilik, 2006) Bahceci, Selen; Nergiz, Yusuf; Bahceci, Mithat; Tuzcu, Alpaslan; Gokalp, DenizLeydig cell aplasia is a rare form of male pseudohermaphroditism. We determined Leydig cell aplasia in a 39 yr old patient, grown up as a female, with female external genitalia and primary amenorrhea. Gonads were bilaterally palpable in the inguinal regions. Karyotype was 46, XY. Hormonal evaluation revealed markedly elevated gonadotropin levels with a low testosterone, which failed to increase after human chorionic gonadotropin stimulation. In Leydig cell aplasia, classically, testicular histology reveals seminiferous tubules, whereas Leydig cells are not present or appear only as immature forms. In addition to classical features of Leydig cell aplasia, we determined diffuse fibrosis, atrophy, interstitial edema and marked thickness in lamina propria of seminiferous tubules, and although Sertoli cells were seen, no germ cell was present. Very long duration of undescended testes (cryptorchidism) may be responsible for these additional histopathological changes. Becasue of a criptorchid testis is more likley to undergo malignant degeneration than normal testes, many urologists recommend orchiectomy for unilaterally undescended testicle.Öğe Levels of proinflammatory cytokines and hs-CRP in patients with homozygous familial hypercholesterolaemia(Acta Cardiologica, 2009) Gokalp, Deniz; Tuzcu, Alpaslan; Bahceci, Mithat; Arikan, Senay; Pirinccioglu, Ayfer Gozu; Bahceci, SelenObjective - Homozygous familial hypercholesterolemia (FH) is an extremely rare (1/1.000.000) condition characterized by markedly increased LDL cholesterol levels and a significantly increased risk of premature coronary heart disease (CHD). We aimed to evaluate the levels of high-sensitivity C-reactive protein (hs-CRP) and proinflammatory cytokines, which are known to be associated with atherogenesis, in patients with this condition. Method and results - A total of 10 patients with homozygous FH (5 women and 5 men, mean age 17.0 +/- 6.9 years, body mass index (BMI) (18.8 +/- 1.9 kg/m(2)) and 16 healthy controls were included. hs-CRP levels, proinflammatory cytokine levels and lipid parameters were measured and compared between patients and control subjects. Homozygous FH patients had significantly higher total cholesterol, LDL-cholesterol and Lp(a) levels and significantly lower triglycericle and HDL cholesterol levels, compared to controls (P = 0.0001, for all). Serum hs-CRP (3.7 +/- 1.3 mg/L vs. 0.6 +/- 0.6 mg/L) and IL-1 beta, IL-2R, IL-6, IL-8, IL- 10, TNF-alpha levels were all significantly higher in the homozygous FH group, compared to controls (P = 0.0001, for all). Conclusions - Homozygous FH patients have significantly higher levels of hs-CRP and circulating proinflammatory cytokines, which may explain their increased risk of atherosclerotic disease. hs-CRP is an important biomarker that may be helpful in the identification of asymptomatic CHD in FH patients.Öğe Lingual Thyroid, A Rare Embryological Aberration of Thyroid Gland and Primary Hypothyroidism(Galenos Yayincilik, 2007) Bahceci, Selen; Tuzcu, Alpaslan; Kemec, Zeki; Tuzcu, SadiyeLingual thyroid is an abnormal formation appearing as the result of a deficient descent during embryological development of the thyroid gland through the thyroglossal duct to its normal pretracheal location, and it is a rare embryological aberration. A 32yr old woman was admitted to endocrinology clinic for hypothyroidism with foreign-body-feeling, swallowing difficulties, dyspnea, hoarseness, constipation, cold intolerance, dry skin, fatigue and lethargy. Oropharyngeal examination showed a spherical, fixed, red fleshy and hard basilingual tumor. The thyroid gland was nonpalpable and patient was diagnosed as primary hypothyroidism. Neck ultrasound showed a heterogeneous, smooth contoured, hypoechoic solid nodular mass on the base of the tongue. Computerized tomography also confirmed this finding. Thyroid scan with technetium 99m revealed isotope uptake in the base of tongue area and no uptake in the normal thyroid location. With these findings lingual thyroid was diagnosed, and the lingual thyroid mass was resected. Biopsy revealed thyroid tissue with noduler colloidal goiter containing hyperplastic nodule. Levothyroxine treatment was started and there was no complication in the postoperative period. We present here a case of lingual thyroid and hypothyroidism in a 32 year old female patientÖğe A rare embryologicaL malformation of brain - Dandy-Walker syndrome - and its association with Kallmann's syndrome(Maghira & Maas Publications, 2007) Aluclu, Mehmet Ufuk; Bahceci, Selen; Bahceci, MithatBackground & Aim: Dandy-Walker malformation, a rare congenital brain malformation, is described as a triad of cystic dilatation of the fourth ventricle, complete or partial agenesis of the cerebellar vermis, and an enlarged posterior fossa with elevated tentorium. We aimed to report an association of Kallmann's syndrome and Dandy-Walker malformation. Case: A fifteen years old boy was referred to endocrinology department due to delayed puberty. Stages of male genital development according to Marshall and Tanner, was stage G1 and P1 respectively. In the LHRH test, peak LH level was 40(th) min.: 15.3 IU/ml. Peak growth hormone with insulin tolerance test was 14.5 mu g/L. Olfactory test revealed light anosmia. With these findings the patient was accepted as isolated gonadotropin deficiency (Kalmann's syndrome). In computed tomography of the brain, cerebellar vermis was found to be hypoplastic and 4(th) ventricle was large and in posterior fossa broad hypodens area with cerebrospinal fluid density were seen (Dandy-Walker malformation). Conclusion: We reported an association of Kallmann's syndrome and DandyWalker malformation. This is second reported case probably.Öğe Sheehan's syndrome as a rare cause of anaemia secondary to hypopituitarism(Springer, 2009) Gokalp, Deniz; Tuzcu, Alpaslan; Bahceci, Mithat; Arikan, Senay; Bahceci, Selen; Pasa, SemirAlthough its exact mechanism is unclear, anaemia is well recognised as a feature of hypopituitarism; and anaemia is associated with Sheehan's syndrome (SS). We aimed to evaluate the frequency and severity of anaemia and other haematological changes among patients with Sheehan's syndrome, in comparison with healthy controls. Sixty-five SS patients and 55 age-matched female healthy controls were included. Biochemical and hormonal assessments and haematological evaluations were carried out, and groups were compared. The mean number of red blood cells, as well as mean haemoglobin, iron and erythropoietin levels, total iron-binding capacity and transferrin saturation were all significantly lower in SS patients compared to controls. SS patients had significantly higher rates of anaemia (80.0% vs. 25.5%, p = 0.0001), iron deficiency (44.6% vs. 5.4%, p = 0.001), leukopenia (20.0% vs. 5.4%, p = 0.015), thrombocytopenia (9.2% vs. 0.0%, p = 0.028) and bicytopenia (21.5% vs. 1.8%, p = 0.001) compared to controls. Anaemic SS patients had normochromic-normocytic anaemia (55%) or hypochromic-microcytic anaemia (45%). Anaemia is frequently associated with Sheehan's syndrome and responds to appropriate replacement therapy. Hypopituitarism should be considered as a possible cause of anaemia, and a hormone examination should be undertaken promptly, particularly in patients with anaemia resistant to therapy and/or with a history suggestive of Sheehan's syndrome.Öğe Ultrastructural evaluation of the effects of cinnamon on the nervus ischiadicus in diabetic rats(Riyadh Armed Forces Hospital, 2009) Bahceci, Selen; Aluclu, Mehmet U.; Canoruc, Naime; Bahceci, Mithat; Akkus, Murat; Baran, Sedat; Gokalp, DenizObjective: To investigate the effects of oral cinnamon supplementation on the nervus ischiadicus at the electron microscopical level in rats. Methods: This study was performed between 20042006 in Dicle University School of Medicine, Diyarbakir, Turkey in 15 adult Sprague-Dawley rats. Rats were divided into 3 groups; control (C) (n=5), diabetic without cinnamon (D) (n=5), and diabetic with cinnamon (D-C) (n=5). Diabetes was induced with intraperitoneal alloxan administration. All diabetic rats were treated with human insulin. AN rats were fed with standard pellet chow. The D-C group rats were fed with standard pellet chow plus Cinnamomum cassia at the dose of 400mg/kg. All rats were sacrificed after 3 months and we obtained the nervus ischiadicus of all rats. Contrast stained thin sections evaluated by Jeol-TEM-1010 electron microscope, were not statistically different in both groups and photo samples were obtained. Results: Mean blood glucose, hemoglobin AlC, and lipid profile were not statistically different in both groups. Marked detachment of myelin lamellae at Schmidt-Lanterman clefts, lysis in cristae mitochondrialis and degenerative changes, severe dispersion of organelles in neurolemma, mesoaxon region, and remarkable edema at the endoneurium were found in diabetic rats. On the contrary, mesoaxon, nucleus, nucleolus and myelin sheet were almost of normal appearance at the ultra-structural level in the D-C group. Conclusions: Cinnamon extracts may have beneficial effects on the development of diabetic neuropathy in alloxan induced diabetic rats.
