Yazar "Babacan, Figen" seçeneğine göre listele

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  • [ X ]
    Öğe
    CHANGES IN SERUM PARAOXONASE ACTIVITY, CALCIUM AND LIPID PROFILES IN PRE-ECLAMPSIA, A PRELIMINARY STUDY
    (Galenos Yayincilik, 2011) Babacan, Figen; Isik, Birgul; Bingol, Banu
    Objective: To investigate serum paraoxonase (PON1) activity, serum calcium, and lipid profiles in pre-eclampsia. Material and methods: Serum PON1 activity, calcium, and lipid profiles were measured in a cohort of 45 women with normal pregnancies (11 patients) and pre-eclampsia (34 patients). Results: Triglyceride, total cholesterol, and LDL cholesterol concentrations were significantly increased in women with pre-eclampsia, compared with women with normal pregnancies. Serum HDL cholesterol, PON1, and calcium levels in pre-eclamptic patients were significantly lower than those in healthy pregnant women. Conclusion: The significant decrease of PON1 activity in pre-eclampsia is related to lipid profiles and calcium.
  • [ X ]
    Öğe
    Changes in serum paraoxonase activity, calcium and lipid profiles in pre-eclampsia, a preliminary study
    (2011) Babacan, Figen; Bingöl, Banu; Işık, Fatma Birgül
    Amaç: Preeklamptik ve normotansif gebelerde serum paraoxonaz (PON1) aktivitesi, serum kalsiyumu ve lipid profillerinin incelenmesi. Gereç ve yöntemler: 34 preeklamptik ve 11 normotansif gebede serum PON1 aktivitesi, kalsiyum ve lipid profillerinin incelenmesi. Bulgular: Preeklamptik gebelerde serum trigliserid, total kolesterol, LDL kolesterol sevyeleri, normotansif gebelerle kıyaslandığında anlamlı olarak daha yüksek bulunmuştur. Serum HDL kolesterol, PON1, ve kalsiyum sevyeleri ise normal gebelere kıyasla preeklamptik kadınlarda daha düşük olarak tespit edilmiştir. Sonuç: Preeklamptik hastalarda PON1 aktivitesindeki anlamlı düşüş, lipid profili ve kalsiyum seviyesi ile ilişkilidir.
  • [ X ]
    Öğe
    Evaluation of biological effects induced by diagnostic ultrasound in the rat foetal tissues
    (Springer, 2007) Karagoz, Irfan; Biri, Aydan; Babacan, Figen; Kavutcu, Mustafa
    In recent years, there has been growing interest in estimating the degree of heating caused by the diagnostic ultrasound in clinical practice. Both theoretical and experimental methods have been suggested for estimating the heating potential, or thermal hazard, of diagnostic ultrasound. Aim of this study was to evaluate in vivo effects of ultrasound exposure of variable duration (from 10 up to 20 min) with commercially available imaging systems commonly used for diagnostic imaging. Numerical results related to the thermal effect are obtained by simulation program based on B-mode (scanning) and Doppler (non-scanning). To investigate the biological effects of the ultrasound exposure to the brain and liver tissues, the antioxidant enzyme activity and thiobarbituric acid reactive substances (TBARS) of the tissues were evaluated. In liver tissue, as a lipid peroxidation index, TBARS levels very significantly increase in Doppler group compared to control. However, in B-mode, TBARS levels are the same with the control group. Use of B-mode in foetal tissue is more reliable than Doppler mode because temperature rise is very small compared to the Doppler mode. On the other hand, the antioxidant enzyme activities tend to increase in B-mode and Doppler groups compared to the control group as a defensive mechanism. In the brain tissue, lipid peroxidation is increased slightly in B-mode compared to the control group. This situation is related to the molecular structure of the brain tissue because of its high lipid concentration. In brain tissue, the antioxidant enzyme activities and lipid peroxidation were significantly increased, such as liver tissue in Doppler groups. Doppler ultrasound may produce harmful effects in rat foetus liver and brain tissues as a result of the high temperature rises.