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Öğe Acquired Glanzmann thrombastenia due to immune thrombocitopenic purpura(2006) Altintaş A.; Ayyildiz O.; Söker M.; Müftüoğlu E.Glanzmann thrombastenia is a rare otosomal ressesive disease which has normal platelet count and morphology, and impairment of platelet aggregation. There is qualitative or quantitative abnormality in GPIIb-IIIa proteins that have a function of receptor to fibrinogen and Von-Willebrand Factor. Mucocutenous hemorrhage, epistaxis, gingival hemorrhage, and hemorrhage were seen especially in young age. The disease may occur rarely as an acquired. Autoantibodies developed in the course of some disease such as Non-hodgkin's lymphoma, Hodgkin disease, multiple myeloma, in patients who are taking immunusuppressive drugs, and particularly in immune thrombocytopenic purpura. We report here, a patient 42 years-old female, who is diagnosed as Acquired Glanzmann thrombastenia due to immune thrombocytopenia.Öğe The analysis of relationship between suicide attempt and the level of serum lipid(2013) Erdem Ö.; Kara I.H.; Ayyildiz O.Objective: In this study, it is aimed to compare the levels of the cases which have drug with the aim of suicide, by right control groups. Method: In this study, the cases which referred to Hospital of Dicle University with drug intoxication have been analyzed. In the study, their lipid; Triglyceride, Total Cholesterol, High Density Lipoprotein Cholesterol and Low Density Lipoprotein Cholesterol level of during first consultation was determined. Results: The lipid levels mean of the group that attempt to suicide were triglyceride 83,7±76,2 mg/dl, total cholesterol 137,5±46.0 mg/dl, HDL-C 38,0±14,0 mg/dl and LDL-C 74,0±39,2 mg/dl. The lipid levels mean of the control group were triglyceride 123,1±51,2 mg/dl, total cholesterol 176,7±48,7 mg/dl, HDL-C 44,0±6,3 mg/dl and LDL-C 107,7±44,4 mg/dl (in return; p=0.020, p=0.001, p=0.040 ve p<0.001). It was determined that there is a negative correlation between attempting to suicide with drug and the level of triglyceride, total cholesterol, HDL-C and LDL-C. Conclusion: As a result, a meaningful correlation has been determined between the levels of triglyceride, cholesterol, and HDL-C and LDL-C and the attempting to suicide.Öğe Assessment of patients with thrombotic thrombocytopenic purpura(2010) Demir C.; Altintaş A.; Paşa S.; Ali Kaplan M.; Küçükzeybek Y.; Ayyildiz O.Thrombotic thrombocytopenic purpura (TTP) is a severe microvascular occlusive thrombotic microangiopathy characterized by systemic platelet aggregation, organ ischemia, profound thrombocytopenia, and fragmentation of erythrocytes. Unexplained occurrence of thrombocytopenia and anemia should prompt immediate consideration of the diagnosis and evaluation of peripheral blood smear for evidence microangiopathic hemolytic anemia. Excellent remission and survival rates were achieved by therapeutic plasma exchange. We reviewed characteristics and response rates to plasmapheresis of our TTP patients. A total of 25 cases were diagnosed. The parameters of hemoglobin and platelet were analyzed at presentation, as well as the number of plasmapheresis sessions and adjunctive treatment given. We found a response rate of 80 percent to plasma exchange. Response was better in 23 patients who presented with idiopathic TTP. Response was poor in patients with TTP secondary to underlying metastatic carcinoma. Two patients relapsed and one of the relapsed patients died. Plasmapheresis is mandatory and effective for primary TTP. Plasmapheresis may not be effective in all instances, especially if TTP is secondary to underlying disseminated cancer.Öğe Autoimmune hemolytic anemia presented in course of Hodgkin's diseases: Report of two cases(2006) Altintaş A.; Ayyildiz O.; Işikdoğan A.; Atay E.; Müftüoğlu E.Autoimmune hemolytic anemia is a rare disorder that the incidence is approximately 1/100000 in adults. 50-70 % of cases are idiopathic. Recently, the percentages of secondary causes have risen due to detailed investigation and long term follow up. Hematologic and nonhematologic malignancies plays an important role in the etiology and pathogenesis of autoimmune hemolytic anemia that has many other causes. Lenfoproliferative malignencies, especially chronic lenfoid leukemia is the most striking disease. The association of Hodgkin's disease and autoimmune hemolytic anemia is being observed as rare case reports. We discussed two cases of Hodgkin's disease associated autoimmune hemolytic anemia in recent 3 years period. One was presented after therapy and the other was presented prior to therapy.Öğe Cancer and thrombotic thrombocytopenic purpura: Presentation of two cases(Turkiye Klinikleri, 2008) Altintaş A.; Çil T.; Atay A.E.; Kaplan M.A.; Işikdoğan A.; Ayyildiz O.Thrombotic thrombocytopenic purpura (TTP) is a rare and fatal disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, neurologic disorder, renal function deterioration and fever. TTP may be idiopathic or secondary to autoimmune diseases, drugs, cancer and infections. Clinical findings of TTP are also present in cancer patients with disseminated intravascular coagulation and sepsis. TTP must be considered in the differential diagnosis in the case of concurrent microangiopathic hemolytic anemia and thrombocytopenia with or without leukoerythroblastic blood smear in cancer patients. Here we presented two patients who were followed up in our clinic with TTP secondary to metastatic breast cancer. Copyright © 2008 by Türkiye Klinikleri.Öğe CD7 positive acute myeloblastic leukemia exhibiting pleural and pericardial involvement as an initial manifestation(2001) Söker M.; Ayyildiz O.; Devecioglu C.; Haspolat K.A 12-year-old girl was admitted to our hospital because of cardiac tamponade and pleural effusion. Her pericardial and pleural fluid contained myeloblasts and a diagnosis of acute myeloblastic leukemia was made from the findings of a bone marrow smear. She was classified as M4 acute myeloblastic leukemia according to French-American-British classification. The surface marker analysis of the blasts was positive for CD7, CD33, CD14, CD34 and HLA-DR. Leukemic pericardial effusion with cardiac tamponade and pleural involvement is very rare as an initial manifestation of acute myeloblastic leukemia. We report a case with a diagnosis of CD7+ acute myeloblastic leukemia presenting initially with pericardial effusion complicated with cardiac tamponade and pleural involvement as an unusual presentation.Öğe Cladribine treatment outcomes of hairy cell leukemia(2006) Altintaş A.; Ayyildiz O.; Atay A.E.; Çil T.; Müftüoğlu E.Hairy cell leukemia is a rare, clonal, chronic B cell lenfoproliferative disease characterized by splenomegaly and pancytopenia. Purine analogues are first-line choice of therapy. Although effectivity of treatment is established, relapses may occur. In this state, remission may achieved by a new cycle of 2-CdA or alternative modalities. In this report, we represented the results of our patients with HCL that were treated with 2-CdA and followed up in our center.Öğe Clinical significance of elevated antinuclear antibody test in patients with Hodgkin's and Non-Hodgkin's lymphoma: A single center experience(2008) Altintas A.; Cil T.; Pasa S.; Danis R.; Kilinc I.; Ayyildiz O.; Muftuoglu E.Aim. There is an increased risk of lymphoma subsequent to autoimmune conditions. Autoimmune disorders may occur in the course of lymphomas. In this study, the association of autoimmunity and related autoantibodies within non-Hodgkin's (NHL) and Hodgkin's lymphoma (HL) patients has been investigated. Methods. The study enrolled 119 patients affected by NHL and 60 patients affected by HL for the presence of autoantibodies and autoimmune diseases. Afterwards, the results between the two lymphoma groups have been confronted. Results. Autoimmune diseases were diagnosed in eight (6.7%) patients with NHL and three patients with HL (5%) (P=0.651). Thirty-four (28.5%) patients with NHL and 14 (23.3%) patients with HL displayed autoantibody positivity (P=0.083). As regards HL cases, antinuclear antibodies (ANA) were detected in 12 (20%) and anti PM-Scl in two patients (3.3%). None the patients had anti Jo-1, anti Scl-70, anti Sm, anti nRNP/Sm, anti single-stranded DNA (anti-ssDNA), anti double-stranded DNA (anti-dsDNA), antihistones, antinucleosomes, anti SS-A, anti SS-B or anti CENP-B autoantibodies. In patients affected by NHL ANA was detected in 16 (13.4%), anti SS-A and anti SS-B in two (1.7%), anti CENP-B in eight (6.7%) and anti PM-Scl in eight patients (6.7%). None of the patients had anti Jo-1, anti Scl-70, anti Sm, anti nRNP/Sm, anti ssDNA, antihistones or antinucleosome antibodies. There was a statistically significant difference between patients with HL and NHL in terms of anti CENP-B positivity (P=0.040). Conclusion. In conclusion, ANA and related autoantibodies can frequently be detected during lymphoma treatment. However, the majority of lymphoma patients with positive ANA did not display autoimmune diseases, demonstrating the lack of a strict correlation between the presence of ANA and autoimmune diseases.Öğe Daunorubicin induced blue-gray hyperpigmentation: A case report(2005) Ayyildiz O.; Şit D.; Söker M.; Kadiro?lu A.K.; Yeşilba?dan A.H.Daunorubicin is used widely in the treatment of acute myeloblastic leukemia (AML). Daunorubicin has some toxicity which limit the usage of drug. Blue-gray pigmentation is an uncommon side effect of daunorubicin. It is one of the side effect which might disturb patient for a long time cosmetically. We report here a hyperpigmentation case with acute myelomonocytic leukemia who is still on the treatment.Öğe Demographical characteristics of the patients with leukemia in Diyarbakir(2003) Işikdo?an A.; Ayyildiz O.; Tiftik N.; Altintaş A.; Müftüo?lu E.The distrubition of leukemias showed variation in various parts of the world. Chronic lymphocytic leukemia is the most common form of leukemia (31% of all leukemias) in western countries, but is rare in Japan. Acute myeloblastic leukemia consist of 80% of adult acute leukemias, whereas acute lymphoblastic leukemia is 20 percent. In this report we analyzed all leukemias according to types, age, sex and peak age. For this reason we analysed 497 leukemia cases followed in our clinic between January 1993-December 1999.Öğe Differential diagnosis of Churg Strauss syndrome: Two cases reports(2007) Altintaş A.; Çil T.; Ayyildiz O.; Şit D.; Müftüoğlu E.Churg-Strauss syndrome (CSS) is characterized by necrotising, eosinophilic-rich granulomatous inflammation of small and medium vessels. Differantial diagnosis with Hypereosinophilic syndrome is crucial. Herein, we presented two patients with eosinophilia and eosinophilia related organ damage and emphasize the clinical properties and differential diagnosis of CSS and Hypereosinophilic syndrome; which has many similarities.Öğe Do cellular phones alter blood parameters and birth weight of rats?(2000) Daşdağ S.; Akdağ M.Z.; Ayyildiz O.; Demirtaş Ö.C.; Yayla M.; Sert C.The present study aimed to investigate the effects of microwaves (MW) emitted by cellular phones (CPs) on peripheral blood parameters and birth weights of rats. Thirty-six albino rats were divided into four groups, male (n = 6) and female sham-exposed groups (n = 12) and male (n = 6) and female experimental groups (n = 12). No blood parameters differed following exposure (p > 0.05). The birth weight of offspring in the experimental group was significantly lower than in the sham-exposed group (p < 0.001). No significant differences were observed between rectal temperatures of rats in the sham and experimental groups (p > 0.05). The specific absorption rate (SAR) was found to be 0.155 W/kg for the experimental groups. All parameters investigated were normal in the next generation of rats (p > 0.05).Öğe Eosinophilia and related hematological disorders: Review(Turkiye Klinikleri, 2007) Altintaş A.; Özmen Ş.; Ayyildiz O.Eosinophilia is defined by an eosinophile count of >600/mm3; it may be primary or secondary due to the underlying cause. End-organ damage may develop in familial form as well as primary or secondary eosinophilia and it may also develop regardless of a specific cause in severe or mild eosinophilia;. Recently, the pathogenesis of clonal hypereosinophilia is well recognized and different variants are defined. Copyright © 2007 by Türkiye Klinikleri.Öğe Fever due to malaria in neutropenic patient. A rare complication of blood transfusion(2004) Isikdogan A.; Ayyildiz O.; Soker M.; Yakut M.; Muftuoglu E.[No abstract available]Öğe Hairy cell leukemia variant and differantial diagnosis: Case report(2006) Altintaş A.; Işikdoğan A.; Ayyildiz O.Hairy-cell leukemia-variant is an uncommon chronic B cell lymphoproliferative disorder, characterized by splenomegaly and leukocytosis. A variant form of Hairy-cell leukemia has been considered with features intermediate between Hairy-cell leukemia and B-prolymphocytic leukemia. Although there are some cases diagnosed during routine diagnostic tests, most of them admit with abdominal discomfort secondary to massive splenomegaly. A 72-years old female patients with abdominal distention, early satiety, and night sweating for 2 years admitted and a diagnosis variant form of hairy cell leukemia was established. In this report, we discussed clinic and laboratory features of Variant-Hairy cell leukemia.Öğe Hepatitis B virus infection in patient with Hodgkin's and non-Hodgkin's lymphoma and clinical significance(2007) Altintaş A.; Kaplan M.A.; Çil T.; Yilmaz Ş.; Bayan K.; Daniş R.; Ayyildiz O.Hepatitis B virus (HBV) is a hepatotrophic virus that have also a potential to replicate in lymphoid cells. This has led to evaluation of potential association between HBV infection and lymphomas. In this study, we retrospectively determined the HBV surface antigen and anti-HBs antibody in Southeastern region of Turkey where the prevalence of this infection is relatively high. A total of 276 patients were recruited, 203 (73.6%) with non-Hodgkin's lymphoma (NHL) and 73 (26.4%) with Hodgkin's lymphoma (HL), in the period of January 1995 and December 2005. In total, 40 (14.5%) patients were positive for HBsAg. Of them, 12 (16.4%) were in HL group and 28 (13.7%) were in NHL group. Anti-HBs antibody was positive in total of 123 patients [29 (39.7%) in HL and 94 (46.3%) in NHL]. Eleven patients were taken lamivudine prophylaxis (100 mg po / day) in the last two years. Ten were not developed a reactivation, while one with diffuse large-cell NHL reactivated. Besides, one patients with HL who was not taking prophylaxis developed anti-HBcIgM positive with aminotransferase elevations compatible with acute hepatitis. Although HBsAg positivity was higher in lymphoma patients than in general population in our study, for a possible casual association there is need for prospective studies with wider populations. In conclusion, prophylaxis with lamivudine of HBV carriers is important and treatment should be continued until one year after termination of chemotherapy.Öğe Horizontal pigmented nail bands during daunorubicin treatment [2](2004) Soker M.; Ayyildiz O.; Işikdo?an A.; Çelik M.[No abstract available]Öğe Öğe Inhibitors in hemophilia A and B in Southeast of Turkey(2006) Altintaş A.; Ayyildiz O.; Çil T.; Söker M.; Müftüoğlu E.Hemophilia A and B are inherited, X chromosome linked coagulation disorders that characterized by clinical signs and symptoms seen in males. The most important treatment related complication was viral infection in the past years, but this problem is overcoming by developing of modern factors concentrate which are available in the market, nowadays. However, developing inhibitor against concentrated factors that used is the most important problem, as in western countries. In this study, we aimed to evaluate the inhibitor developing rate in 73 hemophiliac pediatric and adult patients who have treated and followed up in Dicle University hematology polyclinics in Southeastern Anatolia. 62 (85%) of cases were hemophilia A and 11 (15%) were hemophilia B. Of hemophilia A patients 41 (66.2%) had severe and 17 (27.4%) had moderate disease. The same rates were 7 (63.6%) and 3 (27.3%) in hemophilia B patients, respectively. Only one patient (2.4%) with severe hemophilia A had high titrate of inhibitor positivity (17 BU/ml). Inhibitor was present in any of hemophilia B patients. This rate was lower than previously reported data from community of Turkey. We proposed that the most important cause of this low frequency of inhibitor is using fresh frosen plasma in treatment of those patients with bleeding.Öğe Intracranial myeloid metaplasia in idiopathic myelofibirosis(2004) Ayyildiz O.; Isikdogan A.; Soker M.; Celik M.Extramedullary hematopoiesis is a common finding in idiopathic myelofibrosis and is generally found in the liver, spleen and lymph nodes, but meningeal extramedullary hematopoiesis is very rare. Some diseases may be causes of intracranial masses and diagnosis is difficult. We present a case diagnosed as intracranial and meningeal extramedullary hematopoiesis with idiopathic myelofibrosis inducing serious headache.
