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    Öğe
    Evaluation of serum ghrelin levels in patients with vitiligo
    (OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2014) Demir B.; Uçak H.; Çiçek D.; Erden I.; Dertlio?lu S.; Aydin S.; Halisdemir N.
    Objective: There are several publications about vitiligo being related to metabolic disturbances such as insulin resistance, lipid abnormalities, and metabolic syndrome. Plasma ghrelin levels were found to be low in obese patients and it is accepted to be one of important findings of metabolic syndrome such as hyperinsulinemia and insulin resistance. The current study aimed to investigate change in serum ghrelin levels in patients with vitiligo. Material and Methods: A total of 30 patients presenting with vitiligo and 30 control subjects participated in this study. Fasting blood glucose, serum lipids, insulin, C-peptide and thyroid function tests were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate insulin resistance. Ghrelin levels were determined by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's protocol. Results: The mean serum ghrelin levels in the vitiligo patient group was 45.27±16.12 pg/mL and was statistically significantly higher in the control group 35.89±19.37 pg/mL, (p=0.04). The mean serum ghrelin level in the patients with insulin resistance 31.65±16.69 pg/mL was compared to the patient without insulin resistance 43.55±17.99 pg/mL and found statistically significant lower (p=0.02). Conclusion: In conclusion, the researchers found that ghrelin levels in patients with vitiligo were significantly high compared with controls and the researchers could not correlate this condition with serum glucose levels and body mass index. This increase in serum ghrelin levels in patients with vitiligo might be related to oxidative stress. Copyright © 2014 by Türkiye Klinikleri.
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    Öğe
    Physiology and clinical role of salusin-? and salusin-? peptides in the cardiovascular system: Review
    (Turkiye Klinikleri, 2014) Aydin S.; Eren M.N.; Aydin S.
    Hypertension and atherosclerosis are the major cause of cardiovascular diseases and the leading cause of death globally. Some peptide hormones play key roles in the regulation of the pathogenesis of hypertension and atherosclerosis. In this sense, salusin-? (28 amino acids) and ? (20 amino acids) are two new important peptides that cause strong hypotension and bradycardia. Both peptides are broadly expressed in kidneys, blood vessels, hypothalamus, pituitary gland, (hypophysis) and human coronary atherosclerotic plaques, with dominance of salusin-? in macrophage foam cells, fibroblasts, and vascular smooth muscle cells (VSMCs), where it exerts different functions. Indeed, salusin-? had a role macrophage foam cell formation in the human, albeit salusin-? had not. Both salusin-? and salusin-? improved calcium uptake and protein synthesis in neonatal rat cardiomyocytes through the calcineurin, calcium, microtubule-associated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) and protein kinase C (PKC) signal pathways. As stated above, both salusin-? and -? were multifunctional bioactive peptide hormones, and both of them play a pivotal role in the maintenance of blood pressure homeostasis and the pathogenesis of atherosclerosis. Therefore this review focuses on role of salusin peptides in the cardiovascular system as they play a major role in regulating blood pressure and the pathogenesis of atherosclerosis. Copyright © 2014 by Türkiye Klinikleri.