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    EPR study of free radicals in amino acids derivatives irradiated by gamma rays
    (2011) Aydin M.; Osmanoglu Y.E.
    Exposure of powders forms of DL-arginine hydrochloride and glycine hydrochloride to gamma radiation results in the formation of free radicals detected by electron paramagnetic resonance spectroscopy at room temperature. The observed radicals were assigned to be NH2(NH)NH?HCH2CH2CH(NH2)COOH and (NH+3) ?HCOO-respectively. The g values and the hyperfine coupling constants of the unpaired electron with the environmental protons and 14N nucleus were determined for these two radicals. These results were compared with the earlier studies on amino acid derivatives.
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    Prognostic factors and in-hospital outcome of native valve endocarditis in Turkey. A multicenter study
    (Acta Medica Mediterranea, 2014) Ata Akil M.; Acet H.; Elbey M.A.; Aydin M.; Bilik Z.; Yildiz A.; Yuksel M.
    Aim: To investigate the predisposing factors, demographic and clinical characteristics, echocardiographic and prognostic features, and outcomes of patients with native valve infective endocarditis (IE) in Turkey in a multicenter based study. Materials and methods: The study population consisted of 158 consecutive patients with native valve IE (NVE). Data on demographics, medical history, medications, clinical procedures, predisposing factors, clinical examination, microbiology, antibiotic therapy, echocardiography, surgery, complications, and outcome were collected and compared. Results: The mean age of the patients was 47±19 (range 13-87). Seventy seven patients (49%) were female. Of the 158 NVE patients, 49 died during hospitalization. Mortality rate was 31%. Twenty eight patients experienced a stroke. The patients who died during hospitalization were significantly older than the survivors and had higher mean heart rate, white blood cell, C reactive protein, creatinine, poor NYHA functional class, multiple vegetations and large vegetations. Culture-negative endocarditis was seen in 54 cases (34%). Staphylococci were the most common causative organisms (28%). Eighty patients had undergone surgical treatment (51%). Hemoglobin, presence of multiple vegetation, vegetation size (>10 mm), septic shock and poor NYHA class on admission were independent risks for in hospital mortality and stroke. Beside these variables C reactive protein was also an independent risk for in hospital mortality Conclusion: Native valve IE in Turkey was associated with high in-hospital mortality. Rheumatic heart disease continues to be the most common underlying heart condition and echocardiographic findings on admission were the most important independent predictors of mortality or stroke.
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    Statin therapy and increased coronary heart disease risk in primary prevention of people with enhanced low-grade inflammation
    (OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2014) Onat A.; Aydin M.; Köro?lu B.; Can G.; Kaya H.; Ademo?lu E.
    Objective: We investigated whether statin treatment, associated with slightly increased risk of incident diabetes, confers elevated coronary heart disease (CHD) risk, and circumstances thereof.Material and Methods: Totally, 2959 participants 270 of whom were medicated with statins, and free of CHD at baseline, were analyzed at 7.9-years' follow-up using Cox regression.Results: Participants using statin at baseline-compared with remaining participants-had significantly higher values of metabolic syndrome (MetS) components, but lower apolipoprotein B, were fewer current smokers, and had similar HDL- and LDL-cholesterol levels. Women additionally had higher plasma fibrinogen and lipoprotein[Lp](a). Adjusted Lp(a) concentrations were significantly associated with statin medication, especially in men. In Kaplan-Meier analyses for 381 incident CHD cases (stratified to gender, age category and changed status of statin usage) demonstrated steadily separating curves in statin users, compared with non-users (Log rank <0.0001). Cox regression hazard ratio for developing incident CHD was 2.42 (95% CI 1.80; 3.25) in individuals using statin, after adjustment for traditional risk factors, in men irrespective of MetS-status.Conclusion: Appropriately instituted statin therapy in population subsets with MetS or enhanced inflammation may increase CHD risk in a primary prevention setting. Excess risk imparting may be attributed to a modifying effect of statins on Lp(a). Copyright © 2014 by Türkiye Klinik leri.