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    The effect of coenzyme Q10 on venous ischemia reperfusion injury
    (Academic Press Inc Elsevier Science, 2016) Ozalp, Burhan; Elbey, Huseyin; Aydin, Hulya; Tekkesin, Merva S.; Uzun, Hafize
    Background: Coenzyme Q(10) (CoQ(10)) is a lipid-soluble benzoquinone with antioxidant features that make it important in the treatment of ischemia reperfusion injury. In this study, we aimed to investigate the beneficial effect of CoQ(10) in the treatment of venous ischemia/reperfusion injury. Methods: Eighteen Sprague-Dawley male rats were randomly divided into two equal groups: the control group and an experimental group (n = 9 rats). The experimental group received CoQ(10) orally, and the control group received a control diet for 8 wk. An inferior epigastric island flap was raised, and the inferior epigastric vein was clamped for 9 h; the flap was then reperfused. All rats were sacrificed on postoperative day 5. The flap survival rate and levels of CoQ(10), malondialdehyde, glutathione, and superoxide dismutase were assessed, and flap tissues were examined under a light microscope (x200 magnification) after being stained with Hematoxylin & Eosin. Results: The flap survival rate and levels of CoQ(10), glutathione, and superoxide dismutase were significantly higher, but level of malondialdehyde was lower in the experimental group. The mean flap survival rates and plasma levels of CoQ(10) were 51% +/- 24% and 251 +/- 11 ng/mL in the control group, whereas they were 88% +/- 7% and 692.8 +/- 79.7 ng/mL in the experimental group with statistically significant differences (P < 0.001). Polymorphonuclear leukocyte infiltration was higher, and surface epithelial integrity was more impaired in the control group. Conclusions: We concluded that CoQ(10) supplementation has a beneficial effect on venous ischemia and/or reperfusion injury and improves flap survival rate. (C) 2016 Elsevier Inc. All rights reserved.
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    Reduction Mammaplasty Using Bipedicled Dermoglandular Flaps and Free-Nipple Transplantation
    (Springer, 2010) Guven, Erdem; Aydin, Hulya; Basaran, Karaca; Aydin, Utkan; Kuvat, Samet Vasfi
    Secondary revisions due to deflation, flattening, and ptosis have been the major concerns after free-nipple breast reduction procedures. This study used a new modification of the standard technique known as the bipedicled dermoglandular flap method to reduce reoperation rates. A total of 24 patients were treated with the bipedicled dermoglandular free-nipple method between the years 2004 and 2008. The mean patient age was 45.6 years, and the average body mass index (BMI) was calculated as 27.8 kg/m(2). In contrast to the standard technique, the superior dermoglandular flap was fixed as backfolded, whereas the inferior flap was fixed directly to the pectoralis fascia together with the superior flap with polydiaxanone sutures. An average breast tissue volume of 1,736 g was removed. One case of seroma and one case of partial nipple graft loss (8%) were observed in the follow-up period. The patients were followed for an average of 32.4 months. Complications such as deflation, flattening, and Regnault's mild (1st degree), moderate (2nd degree), and severe (3rd degree) ptosis were not observed. However minimal glandular ptosis was observed in four cases (16.6%). Central peripheral minimal hypopigmentation was observed in five cases. None of these complications required reoperation. Bipedicled dermaglandular flap modification of conventional free-nipple reduction mammaplasty is a new option for reducing the probable complications of the standard technique.
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    Swelling and Elongated Uvula with Unilateral Vocal Cord Paralysis after General Anesthesia
    (Aves, 2014) Ozalp, Burhan; Guven, Erdem; Aydin, Hulya
    Swelling and elongated uvula and vocal cord paralysis are very rare complications of general anesthesia. This report illustrates that these rare complications might occur together after general anesthesia. An adult male patient was operated for glomus tumor in left hand middle finger and six hours after the operation acute respiratory distress was diagnosed. There was no drug allergy in his medical history and breathing difficulty had not been observed after the operation which had been performed under general anesthesia ten years ago. Medical therapy with dexamethasone combined topical epinephrine was applied and complete recovery was obtained without surgery.