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Öğe CHANGE OF ANTIOXIDANT ENZYME ACTIVITIES, SOME METALS AND LIPID PEROXIDATION IN ALZHEIMER'S DISEASE(Carbone Editore, 2016) Arslan, Ayse; Tuzun, Fatma Aykan; Tamer, Sibel; Demir, Halit; Aycan, Abdurrahman; Demir, Canan; Tasin, MuhteremIntroduction: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive regression and memory loss. It has been claimed that oxidative stress and factors such as metal accumulation in the brain play important roles in the etiopathogenesis of the disease. Material and methods: The subjects of this study consisted of 24 individuals with Alzheimer's disease and 15 healthy agematched controls. Blood samples were withdrawn from the patients and healthy controls, and the activities of antioxidant enzymes SOD (Superoxide Dismutase), GSH (Glutathion), GSHPx (Glutathion peroxidase), GST (Glutathion S-Transferase) and MDA (Malondialdehyde) levels were determined by Spectrometer. Some metals and heavy metals were measured by atomic absorption spectrometry (AAS). Results: Biochemical analyses showed a significant decrease of the main enzymatic antioxidant defences (SOD, GSH, GST and GSHPx) and increased production of lipid peroxidation marker (MDA) in the serum of AD patients, compared to age-matched control group (p< 0.001). Also the levels of Zn, Mg, and Mn was lower and Fe, Pb, and Cd was higher in the patient group, compared to the control group. Serum Cu and Co levels did not differ significantly between the patient and control groups (p> 0.001). Conclusion: These results supports the theory that in AD there is a defect in the antioxidant defense system, which may lead to oxidative damage. Also alterations in some trace metals and their related enzymes may play a role of etiopathogenesis in AD.Öğe Efficiency of topical rifampin on infection in open neural tube defects: a randomized controlled trial(Taylor & Francis Ltd, 2021) Deger, Ibrahim; Basaranoglu, Murat; Demir, Nihat; Aycan, Abdurrahman; Tuncer, OguzObjectives Neural tube defects are the second most common congenital malformation in humans. Despite significant decreases in neural tube defects and related mortality and morbidity with recent developments, infections remain an important problem. Research on the role of topical therapy for managing neural tube defects and associated infections in the neonatal period has been limited. This randomized controlled trial aimed to investigate the efficiency of topical Rifampin on infection control in paraplegic newborns with open neural tube defects. Methods Thirty-seven patients who underwent an operation for neural tube defects were included. Topical Rifampin and cefotaxime were administered to 19 patients constituting the case group and local saline and cefotaxime were administered to a control group. Patients were examined for ventriculoperitoneal shunt infection/dysfunction, surgical site infection, urinary tract infection, and sepsis. Results None of the patients using topical rifampin had ventriculoperitoneal shunt infection/dysfunction, surgical site infection, urinary tract infection, or sepsis. In the control group, ventriculoperitoneal shunt infection/dysfunction was found in 4 (22.2%) cases, surgical site infection in 3 (27.7%), urinary tract infection in 3 (27.7%), and sepsis in 5 (27.7%), with statistically significant differences between the groups (p = 0.01, p = 0.032, p = 0.032, and p = 0.002, respectively). No local or systemic side effect was observed regarding rifampin use. Conclusion Topical Rifampin is effective in minimizing complications like sepsis, surgical site infection, urinary tract infection, and ventriculoperitoneal shunt infection due to neural tube defect operations. Further research with larger numbers of cases is needed to implement this practice routinely.Öğe Evaluation of cholinergic enzymes and selected biochemical parameters in the serum of patients with a diagnosis of acute subarachnoid hemorrhage(Walter de Gruyter GmbH, 2023) Aycan, Abdurrahman; Taş, Abdurrahim; Yeltekin, Aslı Çilingir; El-Tekreti, Sama Amer Abbas; Arslan, Ayşe; Arslan, Mustafa; Aycan, NurBackground: Spontaneous subarachnoid hemorrhage (SAH) is the most severe form of hemorrhagic stroke and accounts for 5-7% of all strokes. Several chemical enzymes and cytokines are thought to cause reactions that may affect the mortality and morbidity of SAH patients. This study aimed to examine the possible relationships between these parameters and the occurrence of SAH and the clinical-radiological parameters in patients with acute SAH. Methods: This study evaluated 44 patients, including 20 with SAH and 24 controls. We obtained blood from the patients and control groups, which was stored in heparinized tubes and used in determining tumor necrosis factor alpha (TNF-α), brain-derived neurotrophic factor (BDNF), acetylcholinesterase (AChE), caspase-3, and butyrylcholinesterase (BChE) enzymes. Results: TNF-α, BDNF, AChE, and BChE enzyme levels were not related to the Glasgow Coma scale (GCS) score in the patient group (p > 0.05), whereas higher enzyme levels of caspase-3 were associated with lower GCS scores (p < 0.05). The difference between the control and patient groups in terms of mean TNF-α levels was statistically significant (p < 0.01). The BDNF levels were statistically insignificant in the patient groups (p > 0.05). Caspase-3, AChE, and BChE levels were significantly different between the control and patient groups (p < 0.01). Conclusions: Our results may be valuable for predicting the prognosis, diagnosis, and follow-up of patients with SAH. However, further studies are required to elucidate the relationship between the clinical and radiological results in patients with SAH and certain enzymes, cytokines, and growth factors.Öğe A Neglected case admitted with paraplegia: An intradural extramedullary epidermoid cyst(2012) Eroğlu, Saliha Demir; Özaras, Nihal; Sarıyıldız, Mustafa Akif; Güzey, Feyza Karagöz; Esenyel, Meltem; Aycan, AbdurrahmanSpinal epidermoid tümörler, spinal tümörlerin %1.5-2’sini oluşturan nadir tümörlerdir. Servikal ve torasik spinal kord epidermoid tümörleri oldukça nadirdir. Bu yazıda polikliniğimize üriner inkontinans ve paraparezi ile başvuran torasik bölgede intradural ekstramedüller epidermoid kist tespit edilen 28 yaşında bir olgu sunuldu. Hastanın ilk şikayetleri 16 yıl önce başlamış. Bu dönemde hastaya peroneal muskuler atrofi teşhisi konulmuş ve ayrıntılı tetkik edilememiş. Geç tanı ve tedavi nedeniyle başarılı cerrahi ve kapsamlı fizik tedaviye rağmen mevcut paraparezi ve üriner inkontinans düzelmedi. Spinal epidermoid tümörlerin prognozu histolojik olarak benign oldukları için iyidir. Erken teşhis edilirse tam cerrahi rezeksiyon hastaya iyi nörolojik sonuç sağlar. Nörolojik defisiti mevcut olan hastaların kapsamlı araştırılması ve en erken sürede teşhis konulması hayati önem taşımaktadır.Öğe NEUROSURGICAL INJURIES CAUSED BY THE 2011 VAN EARTHQUAKE: THE EXPERIENCE AT THE VAN REGIONAL TRAINING AND RESEARCH HOSPITAL(Elsevier Science Inc, 2015) Aycan, Abdurrahman; Yener, Ulas; Aycan, Nur; Gonullu, Edip; Dursun, Recep; Gonullu, HayriyeBackground: On October 23, 2011, a devastating earthquake, magnitude 7.2 on the Richter Scale, jolted the province of Van in the east of Turkey and led to hundreds of casualties. Objectives: In this study, we aimed to present our clinical experience in the management of patients with cranial and spinal injuries who were admitted to the Van Regional Training and Research Hospital. Methods: The retrospective study included 44 (77.2%) patients who were referred to the neurosurgery department after being diagnosed with spinal and cranial injuries due to earthquake at the emergency department between October 23 and 27, 2011. Results: The patients comprised 32 male (72.7%) and 12 (27.3%) female patients with a mean age of 23.5 years. The injuries included scalp injury (n=16), burst fracture (n=7), compression fracture (n=3), epidural hematoma (n=9), subdural hematoma (n=3), contusion (n=1), traumatic subarachnoid hemorrhage (n=2), depressed skull fracture (n=3), linear fracture (n=9), cervical fracture (n=2), and pneumocephalus (n=1). Most of the patients (90.9%) had isolated injuries and the others (9.1%) presented with combined cranial and spinal injuries. At discharge, the 3 patients with spinal fractures were paraplegic, and of the 2 patients who were operatively treated due to subdural hematoma, 1 was hemiparesic and the other was hemiplegic. No mortality occurred in our patients. Conclusions: The results of this study demonstrated that, in the aftermath of a natural disaster, conducting correct triage procedures and performing a prompt intervention with appropriate and qualified equipment play key roles in reducing morbidity and mortality. (C) 2015 Elsevier Inc.
