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    The possible association of polymorphisms in MTHFR, MTRR, and MTHFD1 genes with male infertility
    (2013) Balkan M.; Atar M.; Erdal M.E.; Yildiz I.; Hatipoğlu N.K.; Bodakç M.N.; Ay O.I.
    Objective: The aim of this study was to investigate the association of the methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), and methylenetetrahydrofolate dehydrogenase (MTHFD1) polymorphisms in idiopathic infertile men and fertile men. Materials and Methods: Case-control study comprising a total of 233 individuals including 108 idiopathic infertile men with nonobstructive azoospermia and 125 fertile men as control. MTHFR C677T, A1298C; MTRR A66G; and MTHFD1 G1958A polymorphisms were studied by Real-Time PCR System. The results were analyzed statistically and a P value <. 05 was considered significant. The Chi square test was used to analyze the genotype distributions of polymorphisms. Results: Single-marker analysis revealed that none of the four polymorphisms was significantly associated with nonobstructive azoospermia. All groups were tested for Hardy-Weinberg equilibrium and the deviation from the Hardy-Weinberg equilibrium takes place for MTHFR C677T (P < 0.05) a combination of controls and infertile group. We also performed a multifactor dimensionality reduction (MDR) analysis to investigate any potential epistatic interactions among the four polymorphisms and male infertility. We found a synergistic interaction between some polymorphisms (P < 0.05). Conclusion: Our findings therefore suggest no individual but interactive association between four prominent folate metabolism pathway markers and male infertility among population in the Southeast Turkey. © 2013 Japan International Cultural Exchange Foundation & Japan Health Sciences University.