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    Öğe
    MicroRNA-related gene polymorphisms and idiopathic azoospermia
    (Wiley-Blackwell, 2016) Balkan, M.; Ay, O. I.; Erdal, M. E.; Rustemoglu, A.; Atar, M.; Hatipoglu, N. K.; Yildiz, I.
    [Abstract Not Available]
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    Öğe
    THE TUMOR NECROSIS FACTOR-A (TNF-A) GENE-308 G/A POLYMORPHISM AND THE TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND (TRAIL) GENE POLYMORPHISMS IN BEHCET'S DISEASE
    (Diagnosis Press Ltd, 2010) Isi, H.; Erdal, M. E.; Akdeniz, S.; Oral, D.; Ay, O. I.; Tekes, S.; Sula, B.
    Behcet's disease (BD) is a chronic, multisystemic inflammatory disease. The specific etiology of BD remains elusive, but the interaction between infectious-agent exposure and genetic factors may have a role. In this report, we aim to investigate the possible association between pathogenesis of the BD and TNF-alpha gene 308A/G (rs1800629) polymorphism and the TRAIL gene (Arg141His, G422A (rs6557634), Thr209Arg, C626G (rs20575) and Glu228Ala, A683C (rs20576)) polymorphisms in people from southeast of Turkey. The study population consisted of 55 BD patients and 80 healthy subjects. All samples were collected and studied between July 2009 and January 2010. Polymorphisms were detected by polymerase chain reaction restriction fragment length-polymorphism (PCR-RFLP) analysis. The patients and healthy control groups were similar with respect to their ages and sex characteristic. Statistically, there was not significant difference between the BD patients and healthy control groups in terms of TRAIL Arg141His, G422A (rs6557634) polymorphism, TRAIL Thr209Arg, C626G (rs20575), TRAIL Glu228Ala, A683C (rs20576) and TNF-alpha-308 G/A (rs1800629) polymorphisms. We could not detect statistically significant difference between the BD patients and healthy control groups according to TNF-a-308 G/A (rs1800629), TRAIL Arg141His, G422A (rs6557634), TRAIL Thr209Arg, C626G (rs20575) and TRAIL Glu228Ala, A683C (rs20576) gene polymorphism.
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    Öğe
    THE TUMOR NECROSIS FACTOR-A-308 G/A POLYMORPHISM AND THE TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND POLYMORPHISMS, IN ASTHMATIC PATIENTS AND HEALTHY SUBJECTS
    (Taylor & Francis Ltd, 2010) Isi, H.; Oral, D.; Yildiz, T.; Ates, G.; Sinir, C.; Ay, O. I.; Turkoz, G.
    Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. Like other atopic diseases, asthma is a complex disorder caused by interactions between multiple genes of small to modest effect and equally important environmental factors. The aim of this study was to determine the TNF-alpha-308 G/A polymorphism and the TRAIL polymorphisms, and their influence on asthma in asthmatic patients and healthy subjects. The study population consists of 51 asthmatic patients (47 female and 4 male) and 72 healthy subjects (62 female and 10 male). The mean age of the asthmatic patients and healthy controls were 45.33+/-14.05, and 41.88+/-17.41 years, respectively. The asthmatic patients and healthy controls were similar with respect to their ages and sex characters. There was statistically a significant difference between the asthmatic patients and control groups in terms of TRAIL Arg141His, G422A (rs6557634) polymorphism (p=0.02). Statistically, there was not any significant difference between the asthmatic patients and control groups for TRAIL Thr209Arg, C626G (rs20575) TRAIL Glu228Ala, A683C (rs20576) and polymorphisms (p=0..57). Also, there was no significant difference between the asthmatic patients and control groups in terms of TNF-alpha-308 G/A polymorphism (p=0.90). In our study, the TRAIL Arg141His G422A (rs6557634) polymorphism was detected for the first time in asthmatic patients, which may influence the susceptibility to the asthma.