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Neuroprotective Effects of Olanzapine in N-Methyl-D-Aspartate-Induced Retinal Injury
(Mary Ann Liebert, Inc, 2013) Onder, Halil Ibrahim; Aktan, Gulderen; Yuksel, Harun; Avcioglu, Sedat; Yildirim, Umran; Kaya, Murat; Tunc, Murat
Purpose: The aim of this study was to investigate the neuroprotective effect of olanzapine (OLA), an atypical antipsychotic drug, on N-methyl-D-aspartate (NMDA)-induced retinal injury. Methods: Retinal neuronal ischemia was induced by NMDA in Wistar rats. OLA was administered intraperitoneally in 2 different dosages: 2 and 12 mg/kg. At the end of 2 weeks of OLA treatment, 1 eye of each animal was enucleated for histopathologic examination. We also measured malondialdehyde (MDA) levels in retinal homogenates as a marker of ischemic injury. Results: The retinal ganglion cell (RGC) count was significantly higher in cases where we used OLA 2 mg/kg or OLA 12 mg/kg compared to the control group (P = 0.0032 and P = 0.0005, respectively). We also found that MDA was significantly reduced by OLA 2mg/kg or OLA 12 mg/kg compared to the control group (P = 0.0001 and P = 0.0001, respectively). There was no statistically significant difference between OLA 2 mg/kg or OLA 12mg/kg groups in terms of RGC count and MDA levels (P > 0.05 for all). Conclusion: Our data showed that OLA preserved RGCs from NMDA-induced retinal injury; thus, it may have potential neuroprotective effects.