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Öğe The correlation between adiposity and adiponectin tumor necrosis factor ?, interleukin-6 and high sensitivity C-reactive protein levels.: Is adipocyte size asssociated with inflammation in adults?(Springer, 2007) Bahceci, M.; Gokalp, D.; Bahceci, S.; Tuzcu, A.; Atmaca, S.; Arikan, S.Objective: Hypertrophic obesity correlates with metabolic complications of obesity. We evaluated adipocyte volume and its relationship with tumor necrosis factor ct (TNF-ct), interleukin-6 (IL-6), adiponectin and high sensitivity C-reactive protein (hs-CRP) levels. Subjects and methods: Patients were divided into 4 groups; lean healthy controls [body mass index (BMI): 24.2 +/- 1.4 kg/m(2)], non-diabetic obese patients (30.2 +/- 2.9), obese (30.1 +/- 3.2) and non-obese (22.2 +/- 11.5) Type 2 diabetic patients. TNF-a., hs-CRP, adiponectin and IL-6 levels were measured preoperatively and sc fat specimens were obtained during operation. Semi-thin sections were stained with toluidine-blue and evaluated by light microscopy. Fat volumes were calculated by Goldrick's formulation. Results: Mean adipocyte volumes were higher in obese diabetic patients than in other groups (p<0.0001). Mean TNF-alpha, hs-CRP and IL-6 levels were higher in obese diabetic patients than in control subjects, obese non-diabetic and non-obese diabetic patients (p<0.0001, p<0.02 and p<0.01, respectively). Mean TNF-alpha levels of non-diabetic obese patients were higher than the control group (p<0.05). Mean IL-6 levels of diabetic and non-diabetic obese patients were higher than control subjects (p<0.02 and p<0.0001, respectively). Mean adiponectin levels of control subjects were higher than non-diabetic obese, non-obese diabetic and obese-diabetic subjects (p<0.0001). Mean adiponectin levels of obese diabetic patients were lower than non-diabetic obese subjects (p<0.008). Mean hs-CRP levels were higher in diabetic patients whether they were obese or not. There was a positive correlation between adipocyte size and TNF-a. (p<0.01), IL-6 (p<0.03) and hs-CRP levels (p<0.004), and negative correlation between adipocyte size, adiponectin levels (p<0.0001). Conclusions: TNF-cc, IL-6 and hs-CRP levels were positively, adiponectin negatively correlated with adipocyte size. Therefore, adiposity may be an inflammatory condition.Öğe HEPATITIS C VIRUS GENOTYPES ARE CHANGING IN THE SOUTHEAST OF TURKEY(Diagnosis Press Ltd, 2009) Ozbek, E.; Ozekinci, T.; Mese, S.; Atmaca, S.Hepatitis C virus (HCV) infection is a frequent cause of acute and chronic hepatitis, and may lead to the development of cirrhosis and subsequently hepatocellular carcinoma. It is estimated that about 150 to 200 million people have been in contact with HCV worldwide, and approximately 85% are chronically infected. HCV is a highly heterogenous virus. At least 6 genotypes and more than 50 subtypes marked with letters (e.g. 1a, 1b, 2a, 2b) of the virus, have been detected worldwide until now HCV genotype 1 was detected as the most common genotype in the studies also done in our country. The aim of this study is to determine the HCV genotypes and reveal the change in HCV genotypes in the South-Eastern region of Turkey. Between April 2007 and October 2008, the study evaluated serum samples of 74 patients (40 women) that were HCV RNA positive determined by polymerase chain reaction (PCR). HCV genotypes were determined with Inno-LIPA method. 5'non-coding region (5'NCR) of HCV-RNA was amplified by reverse transcriptase polymerase chain reaction (RT-PCR) and genotyped by line probes in Inno-LIPA assay. The genotype results of HCV in the serum samples were as follows: 87.8% genotype 1b, 4.1% genotype 1, 2.7%genotype 2, 2.7% genotype 3 and 2.7% genotype 3a. Genotype I was determined predominantly in a total of 68 (91.9%) patients.Öğe Hepatitis C virus genotypes are changing in the southeast of Turkey(Elsevier Science Bv, 2009) Ozbek, E.; Ozekinci, T.; Mese, S.; Atmaca, S.[Abstract Not Available]Öğe Lack of correlation between CRP and hepatitis B viral load in serum of patients with chronic HBV(W B Saunders Co Ltd, 2007) Gedik, M.; Ozekinci, T.; Ozbek, E.; Atmaca, S.; Yilmaz, S.[Abstract Not Available]
