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Öğe Association Between Neutrophil to Lymphocyte Ratio and Severity of Coronary Artery Disease(Sage Publications Inc, 2014) Kaya, Hasan; Ertas, Faruk; Islamoglu, Yahya; Kaya, Zekeriya; Atilgan, Zuhal Ariturk; Cil, Habib; Caliskan, AhmetThe aim of this study is to investigate the association between neutrophil to lymphocyte ratio (NLR) and severity of coronary atherosclerosis. A total of 172 patients undergoing coronary angiography were included in the study. Control group consisted of patients with normal coronary arteries. Patients with coronary stenosis were divided into 2 groups by use of Gensini scores. The NLR was higher in severe atherosclerosis group compared with mild atherosclerosis and control groups (P < .001). In correlation analysis, NLR showed significant correlation with Gensini score. A cutoff value of 2.5 for NLR predicted severe atherosclerosis with a sensitivity and specificity of 62% and 69%, respectively. After multivariate analysis, high levels of NLR were independent predictors of severe atherosclerosis together with glucose and high-density lipoprotein. Our study suggests that the NLR is a predictor of severe atherosclerosis that may be useful for cardiac risk stratification in patients with coronary artery disease.Öğe Atypical Presentation in Lymphoma; Cyanosis in Left Hand: Case Report(Aves, 2011) Ozhasenekler, Ayhan; Atilgan, Zuhal Ariturk; Bakir, Sule; Gokhan, Servan; Yilmaz, FevziA 17 year old female patient was admitted to the emergency service with complaints of cough, asthma, and cyanosis in the left hand. Expanding in the mediastinum, a rightward deviation of the trachea was specified in the posterior-anterior lung x-ray. In her thoracic computerised tomography, soft tissue density, rightward deviation of trachea, narrowing inwards from outside with the left major bronchus was observed and there were common lymph nodules on the upper section of the left trachea. These lymph nodes applied pressure on major vascular structures leading to the left arm. Primarily lymphoma was considered because she was a young patient. Diagnosis-based left axial and left nodule excision was carried out. Histopathologically, a non-Hodgkin lymphoma (NHL) was diagnosed. The patient was given chemotherapy. The cyanosis in the hand was healed after the mass decreased, thus decreasing pressure on vascular structures. Lymphoma, which is one of the mediastinal masses, is also considered with congenital cardiac illnesses such as pulmonary hypertension, improved Patent Ductus Arteriosis Eisenmenger Syndrome in young patients admitted to the emergency service with atypical complaints such as cyanosis in the left hand.Öğe The effect of isoniazide on myocardial tissue: protective role of cape(Drunpp-Sarajevo, 2012) Cil, Habib; Yavuz, Celal; Atilgan, Zuhal Ariturk; Demirtas, Sinan; Caliskan, Ahmet; Gunduz, ErcanAim: To investigate a toxic effect of Isoniazide on the myocardial tissue and protective role of the caffeic acid phenyl ester (CAPE). Material and methods: Animals: Male Sprague-Dawley rats were divided into four experimental groups, with ten animals in each group; Control, INH-treated group, CAPE treated group and INH plus CAPE-treated group. Biochemical analyses: Superoxide dismutase activity was measured according to the method described by Fridovich. Lipid peroxidation level in the myocardium was expressed as malondy-aldehyde (MDA). It was measured according to procedure of Ohkawa et al. The total antioxidant capacity of supernatant fractions was evaluated by using a novel automated and colorimetric measurement method developed by Erel (13). Histopathological analyses: Myocardial tissue specimens were fixed in 10% formaldehyde, dehydrated in alcohol solution and were embedded in paraffin for 24 hours and used for histopathological examination. Four micrometer (mu m) thick sections were cut, deparaffinized, hydrated and stained with hematoxyline and eosin (H&E) under a light microscope (Nikon Eclipse 80i, JAPAN). Results: In the INH group, malondialdehyde and total oxidant status levels were significantly higher than those of the control group in the myocardial tissues (p<0.05). In the INH group myocardial TAC levels, activities of SOD and PON-1 decreased compared with control group (p<0.05). CAPE plus INH treatment caused a significant decrease in MDA and TOS generation in the myocardium (p<0.05). Also, CAPE plus INH caused a significant an increase in TAC levels, SOD and PON-1 activities (p<0.05). Conclusion: We have shown that experimental administration of INH is accompanied by in-creased lipid peroxidation and oxidants in myocardial tissues of rats. Therefore, we suggest that oxidative stress is a cause of INH induced cardiotoxicity. Simultaneously, CAPE is a protective agent in this toxicity by overcoming the inactivation of antioxidant enzyme systems by INH. Thereby CAPE may play a role in preventing INH induced cardiotoxicity.Öğe The gastrocnemius muscle hematoma arising from warfarin use: The importance of genotype analysis in hematomas of atypical localization(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2012) Atilgan, Zuhal Ariturk; Tekbas, Ebru Onturk; Atilgan, Serhat; Yazici, Selma; Yavuz, CelalWarfarin is an effective anticoagulant which is used for the prevention of arterial and venous thrombosis. Currently, this type of oral anticoagulant drugs are often used with various indications and rarely leads life-threatening bleeding. Although bleeding into the gastrocnemius muscle, is usually associated with trauma, it may very rarely result from warfarin overdose. In this article, we report a-41-year-old female case with hematoma in the gastrocnemius muscle due to low doses (i.e. 1.25 mg) of warfarin every other. day.Öğe Investigation of the Effects of Leptin on the Cardiovascular System in Patients With Systemic Sclerosis(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2013) Atilgan, Zuhal Ariturk; Islamoglu, Yahya; Tekbas, Ebru; Budulgan, Mahmut; Batmaz, Ibrahim; Tahtasiz, Mehmet; Yuksel, HaticeObjective: Cardiac involvement in systemic sclerosis can be seen, and often remains silent. Leptin, which is often associated with hypertension and regulation of sympathetic tone, has been reported to contribute to the development of atherosclerosis, endothelial dysfunction and thrombosis by acting directly. The aim of this study was to investigate the effects of leptin on the cardiovascular system in patients with systemic sclerosis. Materials and Methods: Twenty-seven patients with systemic sclerosis and 28 healthy subjects as a control group were included in the study. Clinical and laboratory parameters, 24-hour Holter ECG and ambulatory blood pressure monitorings were recorded and serum leptin levels were measured in all subjects. Results: Mean leptin levels were lower in patients with systemic sclerosis than in controls. In 24-hour ambulatory blood pressure Holter recordings, the mean systolic and diastolic blood pressure, daytime systolic and diastolic blood pressure, systolic and diastolic blood pressure values at night were lower in patients when compared with controls. There was no relationship between leptin and heart rate variability parameters. A positive correlation was found between leptin levels and 24-hour ambulatory blood pressure parameters. Conclusion: Decreased serum leptin levels and increased mean heart rate in patients with systemic sclerosis may be the result of increased sympathetic tone.Öğe Left ventricle hydatid cyst mimicking acute coronary syndrome(J Infection Developing Countries, 2012) Tekbas, Ebru Onturk; Tekbas, Guven; Atilgan, Zuhal Ariturk; Islamoglu, Yahya; Cil, Habib; Yazici, MehmetCardiac echinococcosis rarely mimics acute coronary syndrome. The diagnosis of cardiac hydatid cyst might be difficult on account of varying clinical presentations and nonspesific symptoms. A 75-year-old female was admitted to our hospital with typical chest pain. The patient had no history of previous cardiac symptoms or any illness leading to heart disease. Her ECG revealed ischemic changes. However, her coronary angiography revealed noncritical plaques in the left anterior descending artery. The diagnosis of cardiac echinococcosis was identified using echocardiography, computed tomography and magnetic resonance imaging. The patient was referred to cardiac surgery for resection of the cyst; however, she refused surgery. Albendezol 800 mg/day was prescribed.Öğe Ostial Coronary Stenosis and Severe Aortic Stenosis in a Patient With Familial Hypercholesterolemia(Korean Soc Cardiology, 2012) Kaya, Hasan; Ertas, Faruk; Atilgan, Zuhal Ariturk; Demirtas, Sinan; Caliskan, Ahmet[Abstract Not Available]Öğe Platelet Count and Mean Platelet Volume in Patients With In-Hospital Deep Venous Thrombosis(Sage Publications Inc, 2012) Cil, Habib; Yavuz, Celal; Islamoglu, Yahya; Tekbas, Ebru Onturk; Demirtas, Sinan; Atilgan, Zuhal Ariturk; Gunduz, ErcanAim: To investigate the relationship between mean platelet volume (MPV) and in-hospital deep venous thrombosis (DVT). Material and methods: 147 patients with the diagnosis of DVT and 149 control participants were included in the study. For all participants, clinical risk factors, smoking status, and other demographic data were recorded from hospital registries. The data of patients with DVT were compared with the control participants. Results: Mean MPV was significantly higher in patients with DVT than the control group (8.91 +/- 1.86 vs 7.86 +/- 0.9; P < .001). Body mass index, smoking frequency, hematocrit, and platelet count were significantly correlated with MPV. Independent predictors of in-hospital DVT were MPV (odds ratio [OR] = 1.5; 95% confidence interval [CI] = 1.2-1.87; P <= .001), body mass index (OR = 1.17; 95% CI = 1.04-1.34; P = .012), and smoking (OR = 1.83; 95% CI = 1.09-3.08; P = .023). Conclusion: Mean platelet volume was significantly higher in patients with DVT, and it is an independent predictor of in-hospital DVT.
