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    The fabrication of a highly sensitive electrochemical sensor based on AuNPs@graphene nanocomposite: Application to the determination of antidepressant vortioxetine
    (Elsevier, 2019) Ates, Ali Kemal; Er, Engin; Celikkan, Huseyin; Erk, Nevin
    This is the first report to development of a new generation and highly sensitive electrochemical sensing platform based on gold nanoparticles/graphene/(AuNPs@GRP) nanocomposite for the detection of vortioxetine (VOR). The electrochemical behavior of VOR has been investigated through adsorptive stripping differential pulse voltammetry (AdsDPV) on the proposed electrochemical sensor (AuNPs@GRP/GCE). The structural and morphological characterizations of fabricated AuNPs@GRP composite were performed by x-ray diffraction (XRD) and transmission electron microscopy (TEM) methods. A well-defined and irreversible oxidation peak at 972 mV was observed on the surface of AuNPs@GRP/GCE. The proposed electrochemical sensor exhibited outstanding electrocatalytic activity towards the electroxidation of VOR. Under the optimized conditions, the voltammetric response was linearly proportional to VOR concentration at two working range of 0.1-1.0 and 1.0-6.0 mu M with a low detection limit of 50.0 nM. The developed sensor was successfully carried out for reliable determination of VOR in pharmaceutical sample with satisfying recovery results. AuNPs@GRP/GCE could be utilized as a simple, inexpensive and reliable sensing platform for the routine analysis of VOR as an antidepressant drug in pharmaceutical samples.
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    Öğe
    Reduced graphene oxide/platinum nanoparticles/nafion nanocomposite as a novel 2D electrochemical sensor for voltammetric determination of aliskiren
    (Royal Soc Chemistry, 2017) Ates, Ali Kemal; Er, Engin; Celikkan, Huseyin; Erk, Nevin
    This study describes the fabrication of a sensitive and selective graphene-based electrochemical nanosensor for the detection of aliskiren (ALS). It is the first research study where the electrochemical oxidation and determination of ALS were investigated by cyclic voltammetry (CV) and adsorptive stripping differential pulse voltammetry (AdsDPV) using a 2D nanocomposite electrode modified with reduced graphene oxide/platinum nanoparticles/nafion (rGO/PtNPs/NFN/GCE). An rGO/PtNP nanocomposite was synthesized directly from graphene oxide (GO) and platinum salt using a single-step chemical reduction method. The synthesized rGO/PtNPs were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The developed sensor exhibited excellent electrocatalytic activity (i.e. shifting the potential from 1225 to 1059 mV) towards the oxidation of ALS. The voltammetric responses of ALS presented a good linearity with an increase in concentration within two concentration ranges of 0.045-0.45 mu M and 0.45-2.70 mu M with a low detection limit of 8.2 nM. The analytical applicability of the proposed sensor was demonstrated by determining ALS with the recovery result of 97.0% in human blood plasma. The results strongly suggested that the proposed sensor could be promising as an alternative analytical approach for routine analysis of ALS in clinical samples.
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    Synthesis of Thioglycolic Acid-Modified Molybdenum Disulfide Nanosheets for Electrochemical Sensing and Its Application in Molnupiravir Detection
    (Electrochemical Soc Inc, 2024) Ates, Ali Kemal; Er, Engin
    In the modern world, population growth, industrialization, and lifestyle changes have led to a rise in existing and new diseases, increasing global drug consumption. Proper pharmaceutical dosage is vital since drugs are only effective within specific concentration ranges. Therefore, developing reliable analytical methods for drug analysis in pharmaceuticals and biological samples is essential. Electroanalytical methods are particularly advantageous due to their low cost, ease of use, and rapid response. This study introduces a highly sensitive electrochemical sensor based on thioglycolic acid (TA)-decorated metallic phase molybdenum disulfide (MP-MoS2) nanosheets for the selective detection of molnupiravir (MOL), an antiviral drug used in Covid-19 treatment. The TA@MP-MoS2 nanomaterial was characterized using FTIR, TEM, and EIS. Screen-printed carbon electrodes (SPCE) were modified with TA@MP-MoS2 nanosheets to evaluate their electro-chemical and catalytic behaviours towards MOL by cyclic voltammetry (CV) and square wave voltammetry (SWV). The sensor displayed a well-defined electro-oxidation signal for MOL at 0.534 V, with the linear responses in two concentration ranges: 0.50-3.40 mu M and 3.40-9.55 mu M, and a low detection limit of 22.6 nM. The proposed design that has promising results could be an alternative strategy to fabricate the sensitive sensor for the detection of antiviral agents in real samples.
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    Voltammetric determination of linagliptin in bulk and plasma sample using an electrochemical sensor based on L-cysteine modified 1T-MoS2 nanosheets
    (Elsevier, 2021) Ates, Ali Kemal; Celikkan, Huseyin; Erk, Nevin
    In this work, a sensitive and selective electrochemical method using L-cysteine (L-cys) decorated MoS2 modified glassy carbon electrode (L-cys@MoS2/GCE) was developed for the determination of linagliptin (LIN). The characterization of L-cys@MoS2 was performed by Fourier transform infrared spectroscopy (FTIR), x-ray diffraction spectroscopy (XRD), x-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). The method using differential pulse voltammetry (DPV) exhibited two linear working ranges in the concentration ranges of 1.0-75.0 mu M and 75.0-153.4 mu M with a limit of detection (LOD) value of 0.19 mu M. The method was also applied to detect the LIN quantity of the plasma sample with satisfactory recovery results. To sum up, the developed method was successfully applied to the determination of LIN in bulk and plasma samples, and it may be a promising way for the detection of LIN for quality evaluation and clinical monitoring.