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  • Küçük Resim
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    A case report of allgrove syndrome with neurological involvement
    (Society of TURAZ BİLİM, 2015) Pekkolay, Zafer; Kılınç, Faruk; Tuna, Mazhar Müslüm; Soylu, Hikmet; Ateş, Kenan; Tuzcu, Alpaslan Kemal
    Allgrove syndrome is a very rare seen disorder with an autosomal recessive trait. The three characteristics of disease are alacrima, achalasia and adrenal failure. Alacrimia is the first manifestation in most cases. Achalasia and adrenal failure are seen later. Neurological involvement is rare and usually occurs in older age. A woman 22 years old admitted to our hospital with adrenal failure crisis. She had alacrimia and used teardrop for many years. Achalasia was diagnosed after evaluation of her dysphagia. Thus, diagnosis of Allgrove syndrome was done. Autonomic cardiac dysfunction and peripheral motor neuropathy were detected. In conclusion, Allgrove syndrome is rare and has life threatening potential due to adrenal failure. Early diagnosis and appropriate treatment may improve life quality and expectancy. Patients with relevant symptoms should be evaluated for autonomic neuropathy.
  • [ X ]
    Öğe
    A Case Report of Allgrove Syndrome with Neurological Involvement
    (2015) Tuzcu, Alpaslan Kemal; Soylu, Hikmet; Kılınç, Faruk; Tuna, Mazhar Müslüm; Ateş, Kenan; Pekkolay, Zafer
    Allgrove syndrome is a very rare seen disorder with an autosomal recessive trait. The three characteristics of disease are alacrima, achalasia and adrenal failure. Alacrimia is the first manifestation in most cases. Achalasia and adrenal failure are seen later. Neurological involvement is rare and usually occurs in older age. A woman 22 years old admitted to our hospital with adrenal failure crisis. She had alacrimia and used teardrop for many years. Achalasia was diagnosed after evaluation of her dysphagia. Thus, diagnosis of Allgrove syndrome was done. Autonomic cardiac dysfunction and peripheral motor neuropathy were detected. In conclusion, Allgrove syndrome is rare and has life threatening potential due to adrenal failure. Early diagnosis and appropriate treatment may improve life quality and expectancy. Patients with relevant symptoms should be evaluated for autonomic neuropathy
  • [ X ]
    Öğe
    Ejeksiyon fraksiyonu korunmuş kalp yetersizliği ile epikardiyal yağ dokusu arasındaki ilişki
    (2015) Ateş, Kenan
    Amaç: Epikardial yağ dokusu (EYD) viseral yağ dokusunun kalp etrafında depolanmış özel şeklidir. Kalp hastalıkları ve metabolik hastalıklarla ilişkisi kanıtlanmıştır. EYD ile obezite, metabolik sendrom, diyabet, hipertansiyon, gibi korunmuş ejeksiyon fraksiyonlu kalp yetersizliği (KEF-KY) için risk faktörü oluşturan hastalıklarla ilişkisi olduğundan, EYD’nin, KEF–KY’yi öngörmede önemini araştırmak amacıyla bu çalışma yapılmıştır. Gereç ve Yöntem: Kasım 2013 ile Ağustos 2014 tarihleri arasında Dicle Üniversitesi Tıp Fakültesi Kalp Hastanesi’ne başvuran 50-80 yaş aralığındaki hastalardan; kalp yetersizliği(KY) tanısı ile kardiyoloji yoğun bakım ünitesinde yatan 30 hasta KY grubunu, kardiyoloji polikliniğine kardiyovasküler risk faktörleri olup kalp yetersizliği semptomları ile başvuran 30 hasta da kontrol grubu olarak seçildi. Demografik ve klinik özellikler açısından benzer özellikli gruplar oluşturulmaya çalışıldı. Çalışmaya alınan hasta grubundaki hastalar, Avrupa Kardiyoloji Derneği 2012 kalp yetersizliği kılavuzundaki tanı kriterlerine göre belirlendi. EYD ekokardiyografi (GE Vivid S6) cihazı kullanılarak parasternal uzun akstan ölçüldü. EYD iki grup arasında karşılaştırıldı. Bulgular: Epikardiyal yağ dokusu, KEF-KY’li hastalarda, kontrol grubuna göre artmıştı (9.21 ± 0.82 mm ile 7.13 ± 1.39 mm p<0.001). SV hipertrofisi ile ilgili ekokardiyografik bulgular olan IVS (13.03±0.57 mm ile 12.11±2.22 mm p=0.013), LVMI (131.13 ± 18.00 gr/m2 ile 117.90 ± 20.30 gr/m2 p=0.010) ve SV diyastolik disfonksiyon ile ilgili bulgular olan LAVI (60.71 ± 21.53 ml/ m2, 44.92 ± 9.93 ml/m2 p<0.001), E/é (13.87±3.88, 10.12±2.44 p<0.001), KY grubunda daha yüksek bulundu. Obezite göstergesi olarak VKİ anlamlı değilken (p=0.097), viseral obezite göstergesi bel çevresi anlamlı olarak bulundu (p<0.001). KY grubunda anlamlı olarak bulunan EYD, yaş, LVMI, belçevresi, LAVI, E/é parametrelerinin lojistik regresyon analizinde EYD anlamlı bulundu (p=0.012). Bel çevresi sınırda anlamlı bulunurken (p=0.045) diğer parametreler istatistiksel olarak anlamsız bulundu. Sonuçlar: Epikardiyal yağ dokusunu, KY grubunda artmış olarak saptadık. EYD’yi KEF-KY için öngördürücü olarak belirledik. EYD, KEF-KY grubunda artmış olarak bulunduğu için, KEF-KY’nin patofizyolojisindeki inflamasyon biyobelirteçleri arasında gösterilebilir. Anahtar kelimeler; Epikardiyal yağ dokusu, KEF-KY, Komorbid hastalıklar, Obezite, İnflamasyon
  • Küçük Resim
    Öğe
    Importance of epicardial adipose tissue as a predictor of heart failure with preserved ejection fraction
    (Associacao Medica Brasileira, 2022) Ateş, Kenan; Demir, Muhammed
    OBJECTIVE: Epicardial adipose tissue is a special form of visceral fat surrounding the heart. It is associated with cardiac and metabolic diseases. Epicardial adipose tissue is associated with risk factors for heart failure with preserved ejection fraction, such as obesity, metabolic syndrome, hypertension, and diabetes. In this study, we examined the importance of Epicardial adipose tissue as a predictor of heart failure with preserved ejection fraction. METHODS: Patients who were admitted to the Dicle University Medicine Faculty Heart Hospital between November 2013 and August 2014 were recruited for the study. The heart failure group consisted of 30 patients who were admitted to the cardiac intensive care unit, and the control group consisted of 30 patients who were admitted to cardiology polyclinics. We care about patients’ demographic and clinical features to be similar. Heart failure was diagnosed according to the European Cardiology Society 2012 heart failure guidelines. Epicardial adipose tissue was measured with a transthoracic parasternal long axis with an echocardiography device (GE Vivid S6). We compared the Epicardial adipose tissue measurements between the two groups. RESULTS: Epicardial adipose tissue was higher in patients with heart failure with preserved ejection fraction than in the control group (9.21±0.82 and 7.13±1.39 mm, respectively; p<0.001). Echocardiographic findings associated with left ventricular hypertrophy were intact ventricular septum (13.03±0.57 and 12.11±2.22 mm, respectively; p=0.013) and left ventricular mass index (131.13±18.00 and 117.90±20.30 g/m2, respectively; p=0.010). Findings associated with left ventricular diastolic dysfunction were as follows: left atrial volume index (60.71±21.53 and 44.92±9.93 mL/m2, respectively;p<0.001) and E/è (13.87±3.88 and 10.12±2.44, respectively; p<0.001) were higher in patients with heart failure with preserved ejection fraction than in the control group. Body mass index was not a significant indicator of obesity (p=0.097), but waist circumference was a significant indicator of visceral obesity (p<0.001). Logistic regression analyses indicated that Epicardial adipose tissue, age, left atrial volume index, left ventricular mass index, waist circumference, and E/é were significant in the Heart failure group; Epicardial adipose tissue was significant (p=0.012), and waist circumference significance was borderline (p=0.045). CONCLUSIONS: Epicardial adipose tissue was higher in patients with HF than in the control group, and Epicardial adipose tissue was a predictor of heart failure with preserved ejection fraction. In patients with heart failure with preserved ejection fraction, increased Epicardial adipose tissue means that Epicardial adipose tissue can be used as a biomarker of inflammation in the pathophysiology of heart failure with preserved ejection fraction.
  • Küçük Resim
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    Trend of sex differences and predictors of complications of cardiac electronic device implantations in the Southeast Anatolian Region of Turkey: An observational study
    (Gaziantep Üniversitesi Tıp Fakültesi, 2022) Demir, Muhammed; Özbek, Mehmet; Polat, Nihat; Yıldırım, Bünyamin; Argun, Lokman; İldırımlı, Kamran; Toprak, Nizamettin; Aktan, Adem; Ateş, Kenan; Öztürk, Cansu
    Objective: The comparison of complications after cardiac implantable electronic device procedures has not been studied adequately between both genders. Here, we examined the effect of gender on complications in the Southeast Anatolian Region of Turkey. Methods: A total of 1640 patients from 3 centers in the Southeast Anatolian Region of Turkey were randomly selected. We compared major adverse cardiac events (clinically significant hematoma, pericardial effusion or tamponade, pneumothorax, and device infection) between genders. Univariate and multivariate analyses were plotted to identify predictors of outcomes between both genders. Results: The overall rate of major adverse cardiac events was 3.8% (63 of 1640). Major adverse cardiac events occurred in 4.1% (40 of 983) of the men and 3.5% (23 of 657) in the women groups (P=.557). The most complications were device-related infection (2.1%) and pneumothorax (1.3%) in both genders. Single- and dual-chamber pacemakers were more implanted in women than in men (11.7% vs. 6.2% and 32.6% vs. 20.1%, respectively, P < .001). On the contrary, single- and dual-chamber implantable cardioverter defibrillators were more implanted in men than in women (38.1% vs. 19.6% and 8.5% vs. 4.1%, respectively, P < .001). Additionally, warfarin treatment and history of heart failure were found predictors of major adverse cardiac events in multivariable analysis. Conclusions: This small-scale, real-life patient data revealed no remarkable distinction in terms of complications between both genders. Multinational randomized large-scale cohort trials are required to support our results.