Yazar "Atay A.E." seçeneğine göre listele

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    Cancer and thrombotic thrombocytopenic purpura: Presentation of two cases
    (Turkiye Klinikleri, 2008) Altintaş A.; Çil T.; Atay A.E.; Kaplan M.A.; Işikdoğan A.; Ayyildiz O.
    Thrombotic thrombocytopenic purpura (TTP) is a rare and fatal disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, neurologic disorder, renal function deterioration and fever. TTP may be idiopathic or secondary to autoimmune diseases, drugs, cancer and infections. Clinical findings of TTP are also present in cancer patients with disseminated intravascular coagulation and sepsis. TTP must be considered in the differential diagnosis in the case of concurrent microangiopathic hemolytic anemia and thrombocytopenia with or without leukoerythroblastic blood smear in cancer patients. Here we presented two patients who were followed up in our clinic with TTP secondary to metastatic breast cancer. Copyright © 2008 by Türkiye Klinikleri.
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    Cladribine treatment outcomes of hairy cell leukemia
    (2006) Altintaş A.; Ayyildiz O.; Atay A.E.; Çil T.; Müftüoğlu E.
    Hairy cell leukemia is a rare, clonal, chronic B cell lenfoproliferative disease characterized by splenomegaly and pancytopenia. Purine analogues are first-line choice of therapy. Although effectivity of treatment is established, relapses may occur. In this state, remission may achieved by a new cycle of 2-CdA or alternative modalities. In this report, we represented the results of our patients with HCL that were treated with 2-CdA and followed up in our center.
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    Clinical manifestations of tuberous sclerosis complex
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2013) Atay A.E.; Akbas H.; Sakar N.; Pasa S.; Ari S.; Ekin N.
    Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome or in sporadic form characterized by hamartamatous lesions in multiple organs. It affects several sites such as skin, kidney, lung, heart, central nervous system and liver in diferent stages of disease. TSC is caused by mutations on either chromosome 9 (9q34, the TSC1 gene) or chromosome 16 (16p13, TSC2 gene). TSC1 and TSC2 genes encode proteins called tuberin and hamartin; respectively. Although the pathogenetic mechanism is exactly unknown, a possible mechanism is a GTPase-activating protein against Rheb (Ras homolog enriched in brain), which regulates mTOR (mammalian target of rapamycin) signaling. The mammalian target of rapamycin (mTOR), is a serine-threonine kinase that increases cell proliferation and growth. We aimed to review the clinical manifestations and their predictive role on the course of disease.
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    Distribution of gynecologic malignancies in an epidemiologic study from southeast of Turkey
    (2011) Sakar M.N.; Gul T.; Atay A.E.
    Retrospective evaluation of 105 patients with gynecologic malignancy. One hundred and five patients with gynecologic malignancies diagnosed at Obstetrics and Gynecology Clinics of Medical School, Dicle University, Diyarbakir, between 2001 and 2005 were analyzed retrospectively. Gynecologic malignancies were classified. Distribution of 105 patients with gynecologic malignancies were; cervical cancer 19.04%, endometrial cancer 21.90%, uterine sarcoma 10.47%, primary ovarian cancer 40.95%, metastatic ovarian cancer 5.71%, carcinoma of the fallopian tubes 0.95%, choriocarcinoma 0.95%. 17 of 20 (85%) patients with invasive cervical cancer were in stage?IIa. Endometrioid cancer was the predominant (86.95%) histologic type in 23 patients with endometrial cancer. Leiomyosarcoma was the most frequent (72.72%) histologic type in 11 patients with uterine sarcoma. 33 of 43 patients (76.74%) with ovarian cancer had epithelial type carcinoma. Six patients had metastatic ovarian cancer and 4 patients (66.66%) in this group had Krukenberg tumors (signet-ring cells), 1 patient had primary tubal adenocarcinoma and 1 patient had choriocarcinoma. Ovarian cancer was the most frequent gynecologic malignancy in our study.
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    The evaluation of paraoxonase 1 activity in patients with gestational diabetes
    (Acta Medica Mediterranea, 2013) Atay A.E.; Sakar M.N.; Culcu N.S.N.; Simsek H.; Akbas H.; Acar M.; Isik B.
    Material and methods: Sixty five patients with GDM and 66 healthy pregnants were enrolled. Paraoxonase activity, insulin levels, HOMA-IR, demographic features and anthropometric measurements were evaluated. Results: The mean paraoxonase activity was significantly diminished in patients with GDM (p:0,004). Insulin level and HOMA-IR were significantly higher in GDM patients (p:0,004 and p:0,001; respectively). The mean interval between present and previous pregnancy was significantly shorter in patients group (p:0,004). There was a significant correlation between PON1 activity and serum LDL, HDL levels and weight gained during pregnancy (p:0,001,p<0,001 and p:0,002; respectively) but not with weight and parity. However HOMA-IR was significantly correlated with weight and parity (p:0,001 and p:0,002; respectively). Discussion: Diminished PON1 activity and enhanced oxidative stress accompany to insulin resistance in the pathogenesis of GDM. Oxidative stress is associated with weight gained during first 2 trimesters of pregnancy rather than obesity.
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    Patients with Hodgkin's disease: Clinical and pathological evaluation
    (2006) Altintaş A.; Çil T.; Kaplan M.A.; Atay A.E.; Işikdoğan A.; Büyükbayram H.; Ayyildiz O.
    Hodgkins' disease accounts 25% of all lymphoid malignancies and 1% of all cancers. In this study, 150 patients with Hodgkins' disease were reviewed retrospectively and compared according to age, gender, histopathologic subtype and stage of disease. 102 (68%) of patients were male and 48 (32%) were female with a median age of 41 (16-73) years. The frequencies of histopathological subtypes, mixed cellularity, nodular sclerosis, lymphocyte-rich and lymphocyte-depletion, were 63 (42%), 37 (24.6%), 25 (16.6%) and 21 (14%), respectively. Histological subtype was not determined in 4 (2.7%) patients. Distribution of patients according to stages were; 18 (12%) patients were in stage I, 35 (23.3%) patients were in stage II, 52 (34.7%) patients were in stage III and 43 (28.7%) patients were in stage IV. Sufficient staging procedure was not performed in two patients. SPSS 11.0 program was used for statistical analyzes. Patients were divided into two groups; older and younger than 40 years age and no statistical significancy was detected between groups. Also there was no significant relation between histopathological subtype and age. In conclusion; Hodgkin disease predominantly seen in males (M/F: 2.1). Mixed celularity HD was the most frequent subtype and 63.7% of our patients were in advanced stage (stage III ve IV).
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    The predictive role of Paraoxonase 1 (PON1) activity on survival in patients with metastatic and nonmetastatic gastric cancer
    (Societa Editrice Universo, 2014) Atay A.E.; Kaplan M.A.; Evliyaoglu O.; Ekin N.; Isikdogan A.
    Background. Oxidative stress is known to be implicated in the pathogenesis of malignancies including gastric cancer (GC). Paraoxonase 1(PON1) is a member of antioxidant defense system which acts by hydrolysing peroxidases. Our aim is to assess the levels PON1 activity in different stages and localizations of GC and analyze the predictive role of PON1 activity on overall survival in GC. Materials and Methods. One hundred and twenty six patients with GC were enrolled to the study. Patients were divided into two groups; group I (nonmetastatic GC, n=65) and group II (metastatic GC, n=61). Paraoxonase 1 activity, albumine and lactate dehidrogenase levels and whole blood count were analyzed. Union Internationale Contre le Cancer system was used for staging procedure. Results. Patients at advanced N or M stage have significantly lower levels of PON1 (34.26 U/L and 29.88 U/L, p=0.04 and p=0.03; respectively). Gender, Lauren's classification, grade, localization and T stage of tumor have nonsignificant impact on PON1 activity. PON1 activity was a significant prognostic factor in GC as well as metastasis, localization of tumor and low hemoglobine or albumine level. Conclusions. Lower levels of paraoxonase 1 activity in patients with metastatic gastric cancer may reflect the presence of enhanced oxidative stress in advanced stages of the disease. PON1 activity is a significant and independent predictor of overall survival. Identifying novel prognostic markers can help to establish appropriate therapeutic strategies, to determine preventive measures and to improve survival rates. © Società Editrice Universo (SEU).