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    Assessment of the laboratory transmission of brucellosis in an endemic region
    (Acta Medica Mediterranea, 2014) Deveci O.; Tekin R.; Aslan E.; Hosoglu S.; Bozkurt F.; Dayan S.; Demirpence O.
    Objectives: Laboratory-acquired brucellosis (LB) has been one of the most commonly reported laboratory-associated bacterial infections in both endemic and non-endemic countries. Brucellosis is endemic in Turkey. The aim of this study is to describe the risk factors of LB among laboratory healthcare workers. Material and method: A regional survey study was conducted by face-to-face interview in 7 hospitals from Diyarbakir, Mardin and Batman province, in southeaster Anatolia in Turkey. A structured survey questionnaire was administered to the Laboratory healthcare workers, employed in infectious diseases clinics and microbiology departments, who were at risk of Brucella infection. Result: Of the 136 laboratory workers, 13 (9.5%) had a history of laboratory-acquired brucellosis. Logistic regression analysis identified factors independently associated with an increased risk of LB including lack of biosafety cabinet (P<0.005) and a lack of compliance in the use of the same (P<0.005). Using a biosafety cabinet (P<0.005), existence of biosafety cabinet (P<0.005), full adherence to glove use (P<0.005) and male gender(P<0.005) were found to be protective factors. Conclusion: Increased adherence to personal protective equipment and use of biosafety cabinets should be priority targets to prevent LB.
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    Evaluation of mean platelet volume levels in patients with brucellosis
    (Anatolian Journal of Clinical Investigation, 2014) Bozkurt F.; Aslan E.; Devecİ Ö.; Tekİn R.
    Brucellosis is still an important infectious disease, specially in Turkey. During brucellosis there is an inflammation which causes increase in acute phase reactants. Mean platelet volume (MPV) has been shown as an inflammatory marker in some diseases. Our aim were to assess MPV levels of the patients with Brucellosis. Demographic data of the study groups and their complete blood counting, PLT, MPV, ESR, CRP (C-Reactive Protein) values and serum tube agglutination test (STAT) results were recorded. Before and after treatment MPV levels of 100 patients with brucellosis were evaluated comparing with control group’s MPV levels. The average age of patients was 31.1±15.3 and they were 48 (48%) male and 52 (52 %) female. The average age of control group was 35,2±10,5 and they were of 49 (49 %) male and 51 (51 %) female. ESR, MPV, red cell distribution width (RDW), Hemoglobin (Hgb), CRP, PLT and white blood cell (WBC) values were statistically different among groups. MPV levels and RDW values were significantly lower in the pre-treatment group compared with posttreatment ones. Spearman’s correlation analysis showed a significant negative correlation between CRP and MPV values. MPV levels may be useful in the management of patients with brucellosis. © 2014, Anatolian Journal of Clinical Investigation. All rights reserved.
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    [Fascioliasis and brucellosis in same patient].
    (2014) Deveci O.; Aslan E.; Tekin A.; Toka Özer T.; Tekin R.; Bozkurt F.; Çetinçakmak M.G.
    Brucellosis is a zoonotic infectious disease that can affect many organs and systems and leads to very different clinical circumstances. Brucellosis is rare in association with various infectious agents. Fascioliasis is a zoonotic disease caused by Fasciola hepatica, popularly referred to as a large leaf-shaped liver fluke. This case is a 39-year-old male patient, and his complaints began a week ago, which were chills, fever, abdominal pain, nausea, vomiting, weakness, sweating, and widespread pain. The patient was considered brucellosis in the preliminary diagnosis. Rose Bengal test and Wright test (1/640) were detected as positive. Due to patients having elevated liver enzymes, abdominal ultrasound was taken. A liver lesion was seen with abdominal ultrasound. So, abdominal computed tomography (CT) was taken. The CT result report came in the form that at the left lobe of the liver segment 2, largely necrosis that showed no contrast enhancement, approximately 61x63 mm in size (compatible with fascioliasis) is viewed. The patient's IHA test results, required for fascioliasis, were detected as 1/320 positive. Especially for zoonotic diseases in areas with high endemicity, it should be considered that more than one infectious agent can be present together in high-risk patients.
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    Öğe
    Risk factors for central venous catheter-related bloodstream infections
    (EDIMES Edizioni Medico Scientifiche, 2019) Bekçibaşi M.; Dayan S.; Aslan E.; Kortak M.Z.; Hoşoğlu S.
    Our study aimed to identify the risk factors playing a role in central venous catheter-related bloodstream infections (CR-BSI) in a tertiary large volume university hospital. The current prospective clinical trial was conducted in a university hospital with 1400 beds. All demographic data, length of hospital stay, coexisting diseases, features of catheters used, invasive diagnostic and therapeutic procedures and all antibiotics used in patients with CVCs were recorded. A total of 356 CVCs inserted in 281 patients were followed up for 5667 catheter days. The mean duration of catheterization was recorded as 15.9±12.7days. CR-BSI was detected in 46 (12.9%) patients. The incidence of CR-BSI was found to be 8.12 in 1000 catheter days. Advanced age and longer duration of catheterization were found to be independent risk factors for the development of CR-BSI in multivariate analysis. Coagulase-negative staphylococci (15.2%), Candida spp (13%) and Klebsiella pneumoniae (13%) were the agents most frequently isolated. © 2019, EDIMES Edizioni Medico Scientifiche. All rights reserved.