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Öğe Auricular mucormycosis: a case report.(2007) Oktay M.F.; Askar I.; Kilinç N.; Tuzcu A.; Topçu I.Mucormycosis is a rare, saprophytic, invasive, and fulminant fungal disease. It occurs in immunocompromised patients such as those with diabetes mellitus or blood dyscrasia, or in patients under immunosuppressive therapy. A 17-year-old female patient with diabetic ketoacidosis presented with a black-colored lesion in the auricle and external ear canal. Physical examination showed necrosis of the auricle, external ear canal, and neighboring skin. She also had facial paralysis. Debridement of the necrotic tissues was performed and the samples were submitted for microbiologic and histopathologic examination, which showed nonseptate hyphae. Postoperatively, systemic amphotericin B was empirically administered. The patient died on the seventh day.Öğe Bilateral basal cell carcinoma symmetrically appearing on lower eyelids: A case report(2003) Askar I.; Kilinc N.; Aytekin S.Basal cell carcinoma is the most common skin malignancy and is found in skin exposed to the sun. It is rarely seen bilaterally in ears, ankles or breasts. There has been no literature about bilateral basal cell carcinoma of lower eyelids symmetrically. A 68-year-old male patient had been suffering from two lesions on his lower eyelids for two years. The first lesion appeared on the right lower eyelid two years ago and got larger. Then the second lesion occurred on the left lower eyelid a year and a half ago. The patient had worked as a farmer for fifteen years. Physical examination revealed ulcerated lesions, with surrounding hyperemia, 12×6 mm in size, on both lower eyelids. Both lesions were excised and repaired with lateral malar flap+mucosal graft. One year later, there no evidence of recurrence, and postoperative scars were functionally and cosmetically acceptable. We present a case of bilateral basal cell carcinoma involving both lower eyelids symmetrically, reviewing the literature.Öğe Effects of polyglycolic acid bioabsorbable membrane and oxidised cellulose on the osteogenesis in bone defects: An experimental study(2003) Askar I.; Gultan S.M.; Erden E.; Yormuk E.Background: The purpose of the present study was to determine the effects of polyglycolic acid bioabsorbable membrane and oxidised cellulose on the osteogenesis in bone defects. Materials and Methods: Fifty-four male adult New Zealand White rabbits weighing 3.0 to 3.5 kg were used. The rabbits were randomly divided into three groups of eighteen rabbits: the control group (n=18), the polyglycolic acid bioabsorbable membrane group (biofix group, n=18), and the oxidised cellulose group (Surgicel group, n=18). Each experimental group was also randomly subdivided into two subgroups of nine rabbits, one with periosteum and the other without periosteum. A rectangular transosseous calvarial bone defect, 16 × 20 mm in size, was created. In the control group, the calvarial bone defect was not filled. Polyglycolic acid bioabsorbable membrane (Biofix®, Bioscience, Tampere Finland) was implanted over the bone defect area in the biofix group, and oxidised cellulose (Surgicel®, Ethicone, London, United Kingdom) in the Surgicel group. The calvarial bone defects were evaluated-histopathologically in the second, sixth, and tenth weeks. Results: As for the results of sequential bone regeneration, macroscopical and histological aspects were observed. Bone formation was significantly enhanced by oxidised cellulose in the calvarial bone defects covered with periosteum, whereas cartilage formation was observed in bare calvarial bone defects. Conclusion: We believe that oxidised cellulose has osteogenic potential, and that polyglycolic acid bioabsorbable membrane inhibits osteoinductive effect and retards osteogenesis.Öğe Mucosal malignant melanoma in upper aerodigestive tract: Report of two cases(2004) Oktay M.F.; Askar I.; Kilinc N.; Topcu I.Primary malignant melanoma has been seen in virtually all sites and organ systems where neural crest cells migrate. Upper aero-digestive tract is the unusual site. We presented two cases of mucosal malignant melanoma. A 59-year-old female patient had been suffering from nasal airway obstruction and headache for three months, and was admitted to our clinic. There was an upper cervical lymphadenopathy 5 cm in diameter ipsilaterally. Computerized tomography presented a nasal mass originating from the left maxillary sinus, and extending into nasal cavity and the left lateral wall of nasopharynx. Left total maxillectomy and radical neck dissection was performed. Postoperative radiotherapy was applied. A 68-year-old male patient suffering from nasal airway obstruction, hypernasality, dysphagia, and oral bleeding was admitted to our clinic. Oral examination revealed the tumoral mass protruding downward through oropharynx. The second patient referred to medical oncology. There was no recurrence in the first patient 18 months later. And the second patient died one year later. We believe that nasal mucosal malignant melanoma was rare, and carefully evaluated since it may be amelanotic lesion. Nasopharyngeal mucosal malignant melanoma is very rare, and has worse prognosis.Öğe Prefabrication of periosteal graft alone or with oxidised cellulose: An experimental study(2003) Askar I.; Sabuncuoglu B.T.The purpose of this study was to evaluate the feasibility of prefabrication of periosteal grafts, alone or with oxidised cellulose (surgicel®), which was an osteoinductive material using femoral vasculature. Fifteen white New Zealand rabbits were used in both femoral regions (30 grafts), and randomly divided into three groups including five rabbits (10 grafts): the control group, the periosteal graft group, and the periosteal graft+surgicel® group. A periosteal graft, 30×40 mm in size, was obtained from the calvarium of each rabbit. The periosteal graft taken was divided into two equal parts, 20×30 mm. All these periosteal grafts were sutured in the shape of tube. In all rabbits, femoral vasculature and periosteal tube was included in a silicone tube. Additionally, in the control group, femoral vasculature was cut above and below the silicone tube, whereas in the periosteal graft+surgicel® group, surgicel® was added to the periosteal graft. The results were evaluated macroscopically and histopathologically in the second (two rabbits for each group - 4 grafts) and fourth week (3 rabbits for each group - 6 grafts). In the second week, in all three groups, while no osteoid tissue that indicated osteogenesis developed, it was seen that inflamation and increased vascularity occurred. Surgicel® was observed to be absorbed in the periosteal graft+surgicel® group. In the fourth week, fibrotic tissue was developed whereas inflammatory tissue disappeared; any osteoid tissue or lamellar bone was not accompanied in all three groups. In conclusion, we do not believe that periosteum was able to survive as a graft, and we found that neovascularization occurred too slowly to preserve the bone forming qualities of the periosteum. We suggested that it could not be prefabricated, being taken away from its donor site although surgicel® was used as a stimulating material.Öğe Pyogenic granuloma appearing on port-wine stain: A case report(2003) Askar I.; Kilinc N.; Yucetas A.Background: Pyogenic granuloma has been reported to be associated with hemangiomas and hamartomas, including port-wine stain. It has been suggested that the spontaneous development of pyogenic granuloma in port-wine stain might be associated with microscopic arteriovenous anastomoses in highly vascularized areas such as the fingers, hands, lips, tongue and face. Case report: A 25-year-old male patient presented with a history of a reddish, solitary nodule on the posterior cervical area for eight months. There had been an associated port-wine stain at the same localization since birth. Physical examination revealed a solitary, strawberry-like dome-shaped papule, 12 mm in diameter, within a well-demarcated reddish colored surrounding patch which had been present on the posterior cervical area. The lesion was excised, considering pyogenic granuloma arising in a port-wine stain. Histopathologic examination showed a mass of capillaries with variable luminal diameters, infiltration of intlammatory cells, and immature endothelial proliferation in the upper dermis. The capillaries were organized into lobules separated by fibrous stroma and were surrounded by an epithelial collarette. Immunohistochemical staining for factor VIII-related antigen supported all these findings of the port-wine stain. Conclusion: We present a pyogenic granuloma arising in port-wine stain on the posterior cervical area, since the posterior cervical area is not as highly vascular as the fingers, hands, lips, tongue and face. We believed that the collar of the patient's shirt continuously traumatized port-wine stain, and consequently led to the development of pyogenic granuloma.Öğe Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: A case report(2002) Askar I.; Kilinc N.; Aytekin S.Background. Syringocystadenoma papilliferum is an unusual benign tumor most commonly located on the scalp or face, which frequently arises from a nevus sebaceous. Transition of SP to basal cell carcinoma and, rarely, to metastatic adenocarcinoma may occur. Case Report. A 28-year-old female patient had been suffering from a pinkish, painless nodule for 25 years. Physical examination revealed a pinkish, non-tender, painless nodule, 5mm in diameter, on the lower eyelid. The nodular lesion was excised, and the lower eyelid was reconstructed with V-Y advancement flap. Histopathologic examination revealed hyperkeratosis with papillomatosis of epidermis. The dermis showed several cystic invaginations extending downwards from the epidermis. One year later, the postoperative result was cosmetically and functionally acceptable. Conclusion. Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid is of interest, since there were scanty skin appendages. Our paper considers the issue of differentiating between SP and BCC, since SP is asymptomatic and may have similar appearance. We believe that SP may be a transitional step from nevus sebaceous to basal cell carcinoma, since molecular studies show PTCH gene in all three lesions, the origins of SP are still debatable, and both SP and BCC can arise in nevus sebaceous of Jadassohn.
