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    Measurement of postoperative liver volume changes in patients with gastric cancer by computed tomography
    (Yuzuncu Yil University Faculty of Medicine, 2023) Yokuş, Adem; Arslan, Harun; Akdemir, Zülküf; Akbudak, İbrahim; Almalı, Necat; Kotan, Çetin; Doğan, Erkan
    One of the most prevalent cancer worldwide is gastric cancer. Surgical treatment is the only curative method. In this study, we aimed to investigate the changes in liver volume before and after open gastrectomy in patients diagnosed with gastric cancer. We retrospectively analyzed the computed tomography scans of 70 patients who underwent gastric cancer surgery between June 2013 and December 2020. Preoperative and postoperative total liver volume, the volume of segments II -III, and segment IV were measured. The data obtained from volume measurements were compared statistically. Of the 70 subjects included in the study, 48 were male and 22 were female, with an average age of 64.2±11.8 years. In the postoperative phase, the volume of segments II-III and IV dropped significantly compared to the preoperative period (p=0.001 for both). Total liver volume exhibited a mild decrease in the postoperative period, but the total volume loss was not statistically significant (p=0.744). In this study, we detected significant volume loss in segments II -III and segment IV after open gastrectomy. However, the total liver volume reduction was less.
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    Öğe
    The relationship between serum paraoxonase levels and carotid atherosclerotic plaque formation in Alzheimer's patients
    (Termedia Publishing House Ltd, 2016) Arslan, Ayse; Tuzun, Fatma Aykan; Arslan, Harun; Demir, Halit; Tamer, Sibel; Demir, Canan; Tasin, Muhterem
    Low paraoxonase 1 (PON1) activity and carotid atherosclerosis have been suggested to be important risk factors for dementia. However, the studies to date could not fully clarify the relationship between PON1, carotid atherosclerosis and dementia. The present study aimed to measure carotid atherosclerosis and PON1 activity in Alzheimer's Disease and to evaluate the relationship between them. The study included 25 Alzheimer's patients and 25 control subjects, for a total of 50 individuals. The study measured the serum PON1 activity and other biochemical parameters and carotid atherosclerotic plaque values of the participants. The mean paraoxonase activity (31.06 +/- 2.31 U/L) was significantly lower in the Alzheimer's group compared to the control group (59.05 +/- 7.05 U/L) (P < 0.001). Nonetheless, the carotid plaque values were significantly higher in the patient group (3.02 +/- 0.52 mm) compared to the control group (1.84 +/- 0.45 mm) (P < 0.001). Furthermore, there was a negative correlation (81.0%) between PON1 activity and carotid plaque in the overall study group (P < 0.05). Also serum homocystein level was higher in the patient group (22.15 +/- 7.05) compared to the control group (13.30 +/- 3.32). In conclusion, our findings show inverse association between PON1 activity and carotid atherosclerosis in Alzheimer patients: the lower the PON1 activity the more progressed the atherosclerotic process in AD. (C) 2016 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.