Yazar "Arslan, Eda" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Effects of Nicotine on the Submandibular Gland in Rats
    (Sci Printers & Publ Inc, 2015) Arslan, Eda; Samanci, Baver; Samanci, Seyla Bolukbasi; Caypinar, Basak; Sengezer, Tijen; Deveci, Engin; Seker, Ugur
    OBJECTIVE: To evaluate the histopathologic and immunohistochemical effects of systemic use of nicotine on the submandibular glands. STUDY DESIGN: We investigated the effects of nicotine on apoptosis and angiogenesis. Twenty adult Sprague-Dawley rats were divided into 2 groups: nicotine (n=10) and controls (n=10). The rats of the nicotine group were administered 2 mg/kg nicotine sulphate for 28 days. All animals were sacrified at the end of the study, and submandibular samples were removed and prepared for histologic examination. Proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), and Bcl-2 antibodies were used for immunohistochemical examination. RESULTS: In the group treated with nicotine, we observed degeneration in serous cells and striated duct cells, dilation and hemorrhage of blood vessels in the stromal area, and an increase of fibrous tissue and edema. An increase was observed in the number of PCNA-positive cells as compared to in the controls. VEGF expression was found to be positive in vascular endothelial cells and inflammatory cells around the excretory ducts in the stromal area. The duct cells are immunoreactive to Bcl-2 antibody. Apoptosis was observed in some cells of the serous glands and ducts. CONCLUSION: Nicotine administration in this study induced apoptosis with salivary gland cell proliferation and is thought to have affected angiogenesis.
  • [ X ]
    Öğe
    Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats
    (Soc Chilena Anatomia, 2016) Samanci, Baver; Arslan, Eda; Samanci, Seyla Bolukbasi; Caypinar, Basak; Deveci, Engin; Soker, Sevda; Seker, Ugur
    The objective of this study was to evaluate the histopathologic and immunohistochemical effects of propineb on rat nasal mucosa. Twenty adult Sprague-Dawley rats weighing 180-220 g, were used as experimental animals. The rats were divided into propineb and control groups. The control group received distilled water with spray at the same time period. The experiment was terminated after three weeks. In each case, sections of the nosewere taken. In experimental group, microscopic examination of nasal respiratory mucosa revealed that degenerative changes in epithelium were observed in sections of propineb-treated group. There were also leukocyte infiltration and vascular dilatation detected in the connective tissue. We detected CD34-immunoreactive mononuclear cells and endothel cells in the lamina propria of propineb group. In propineb group compared to the control group, the respiratory epithelium, goblet and basal cell nuclei were stained positive for PCNA. Propineb inhalation may be irritating to the nasal mucosa.