Yazar "Arpa, Abdurrahman" seçeneğine göre listele

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    Cerebrospinal Fluid Prognostic Index in Ventriculoperitoneal Shunt Infection
    (Elsevier Science Inc, 2025) Arpa, Abdurrahman; Ozturk, Pinar Aydin
    BACKGROUND: Considering the consequences of shunt infection, the importance of early diagnosis and effective treatment becomes clear. However, there is no clear parameter to predict the management of shunt infection. Since we thought that an index including cerebrospinal fluid (CSF) leukocyte, glucose, and protein levels may affect treatment guidance, we aimed to investigate its effect on prognosis using the index we defined as CSF prognostic index. METHODS: Ventriculoperitoneal shunt infection patients' age, gender, etiology of hydrocephalus, serum glucose, leukocytes, white blood cell, C-reactive protein, CSF leukocyte, glucose, and leukoglycemic index (LGI) at admission were included. A new index was defined to include leukocyte, glucose, and protein values in CSF and investigate their effect on prognosis. CSF prognostic index = CSF leukocyte 3 CSF protein/CSF glucose. RESULTS: The study included 46 patients aged less than 18 years with shunt infection. There was no correlation among serum glucose, C-reactive protein, leukocytes, monocytes, lymphocytes, platelets, serum LGI, CSF LGI, and treatment duration. A positive correlation was found between CSF prognostic index and treatment duration, which was statistically significant (P = 0.011). CONCLUSIONS: The CSF prognostic index is an index that can be easily evaluated with CSF findings at the time of presentation and can predict both the duration of treatment and the need for intrathecal treatment. Considering the use of broader spectrum antibiotherapies initially in patients with a high CSF prognostic index will avoid possible complications, provide less psychosocial impact on the patient and his/her relatives, and reduce the cost of treatment.
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    Choroid Plexus Papilloma and Factor XIII Deficiency: Case Report
    (Karger, 2018) Ozturk, Pinar Aydin; Sanri, Omer; Yilmaz, Adil; Arpa, Abdurrahman; Ozturk, Unal; Ceviz, Adnan
    Factor XIII deficiency is a rare hemorrhagic disorder that can cause spontaneous intracranial hemorrhage and bleeding after surgery. The diagnosis of factor XIII deficiency is difficult before surgical interventions, because coagulation parameters are normal in these patients. Important clinical findings are postsurgical bleeding and recurrent spontaneous intracranial hematomas. These findings should raise the clinical suspicion of factor XIII deficiency. Therefore, diagnosis of factor XIII deficiency is very important for neurologists and neurosurgeons in terms of reducing mortality and morbidity. We present an 8-month-old female patient who developed subdural hematoma after ventriculoperitoneal shunt surgery but not bleeding after choroid plexus papilloma due to FXIII deficiency. (C) 2018 S. Karger AG, Basel
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    The Effect of Hydrocephalus on the Optic Nerve in the Presence of Intracranial Mass
    (Elsevier Science Inc, 2024) Arpa, Abdurrahman; Yigit, Abdullah; Basar, Ibrahim; Yilmaz, Tevfik
    - OBJECTIVE: The measurement of optic nerve sheath diameter is a noninvasive, practical, and economical method used to identify increased intracranial pressure. The purpose of this study is to detect the preoperative and postoperative changes in optic nerve sheath diameter in patients with intracranial mass, to correlate these changes with optic nerve diameter variations, and to evaluate the impact of hydrocephalus on these alterations. - MATERIAL AND METHOD: This study was conducted with patients who presented to our clinic with complaints of intracranial mass, were decided for surgery, and underwent surgical procedures.- FINDINGS: The optic nerve and optic nerve sheath diameter measurement values were different preoperatively and postoperatively, with a significant decrease in the optic nerve sheath diameter in all groups in postoperative measurements, while the optic nerve diameter significantly increased. - CONCLUSIONS: Although there was no significant difference between the effects of hydrocephalus and intracranial mass-related increase in intracranial pressure on the optic nerve and optic nerve sheath, it was observed that hydrocephalus increased intracranial pressure when considering the Evans ratio. It has been determined that as ventricular dilatation increases, so does intracranial pressure, which leads to an increase in the diameter of the optic nerve sheath, resulting in papilledema and thinning of the optic nerve. These findings indicate the importance of early cerebrospinal fluid diversion and monitoring optic nerve sheath diameter in the management
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    Pediatric case of a penetrating lumbar spinal injury
    (Springer, 2024) Arpa, Abdurrahman; Ozturk, Pinar Aydin; Sanri, Omer; Yilmaz, Adil
    Purpose Penetrating spinal injuries are generally extremely rare and are seldom encountered in pediatric patients. The non-compliance of pediatric patients with physical examination can sometimes delay diagnosis and treatment. Here, we present a case of a child who had a fall and suffered penetrating spinal trauma due to a small glass fragment.Case report A penetrating foreign body was detected in the lumbar spinal region of a 2-year-old patient with complaints of increased restlessness on physical activity followed by difficulty in walking. The patient was operated on and followed up without any complications in the perioperative and late postoperative periods.Conclusion A detailed physical examination is necessitated in the pediatric age group because of insufficient anamnesis. The high number of patients per physician, especially in societies having a low socioeconomic standard, prevents detailed examinations, and unnecessary examinations may cause delays in diagnosis. However, one must note that the skin findings of pediatric patients can be very helpful, especially in pediatric neurosurgery, and examination should not be neglected.
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    Rat karotid arterlerinde yapılan anastomozlarda nimodipin ve pentoksifilin maddelerinin damar duvarı üzerine histopatolojik etkilerinin araştırılması
    (2017) Arpa, Abdurrahman; Kemaloğlu, M. Serdar
    Giriş ve Amaç: Serebral iskemi, arteryel kan akımının azalmasına bağlı olarak serebral dokular için gerekli oksijenizasyonun sürdürülememesi durumudur. İskemi sonrasında oluşan reperfüzyon sonucunda, iskemik dokuya ulaşan oksijen, serbest oksijen radikallerini artırarak paradoks sekonder hasarlara neden olur. Bu nedenle enfarkt gelişmeden önce yapılacak revaskülarizasyon, morbiditenin derecesini etkileyebilmektedir. Revaskülarizasyon amacıyla yapılan girişimlerin başarısı stenoz oluşumu, düz kas hücre proliferasyonu ve intimal hiperplazi oluşumu nedeni ile beklenenden daha azdır. Vasküler rekonstruktif girişimlerden sonra gelişen bu hadiseler mortalite ve morbiditenin beklenenden daha yüksek olmasına sebep olmaktadır. Aynı zamanda geç dönemdeki daralma veya restenozda düz kas hücre migrasyonu, proliferasyonu ve ekstrasellüler matriks birikimi sonucu oluşan neointimal hiperplazi önemli rol oynamaktadır. Nimodipin, dihidropiridin türevi olan bir kalsiyum kanal blokörüdür. Pentoksifilin, ksantin türevi (teofilin benzeri) fosfodiesteraz inhibitörü bir ilaçtır. Rat karotis arterinde yapılan anastomozlarda nimodipin ve pentoksifilin maddelerinin damar duvarı üzerine histopatolojik etkilerini araştırdık. Gereç ve Yöntem: Çalışmamızda randomize olarak seçilen, 18 adet Sprague-Dawley tipi erkek veya dişi rat kullanıldı. Deney günü 4 saatlik açlık süresinden sonra ratlara 80mg/kg ketamin + 10 mg/kg ksilazin ile anestezi uygulandı. Anastomoz için sağ karotid arteri, kontrol için sol karotid arteri kullanıldı. Sterilizasyon sonrasında horizontal boyun insizyonu ile common karotid arter eksplore edildi. Karotid arter mikroklemple klemlenerek mikromakasla transekte edildi. 10/0 polipropilenle anastomoze edilerek dokular anatomik planda kapatıldı. Ratlar, 1 haftalık adaptasyon döneminden sonra rastgele seçilmiş üç gruba ayrıldı. Grup 1 ratlar kontrol grubu, grup 2 ratlar nimodipin 10mg/kg intraperitoneal günde tek doz 7 gün verilen grup, grup 3 ratlar pentoksifilin 100mg/kg oral günde tek doz 7 gün verilen grup olarak ayrıldı. Yedi günlük tedavi sonrasında anastomoz yapılan sağ karotid arteri ve yapılmayan sol karotid arteri 1 cm’lik segmentler halinde çıkarılarak patoloji laboratuvarına gönderildi. Alınan materyaller formol solusyonunda korunarak hematoksilen-eozin, PAS, masson ile boyanıp aynı patolog tarafından incelendi. İnflamasyon, damar duvar hasarı, intimal hiperplazi, lümen çapı, tunika media kalınlığı, trombüs, lümen alanı değerlendirildi. Bulgular: Anastomoz sonrasında kullanılan pentoksifilinin intimal hiperplaziyi azalttığı, lümen çap ve alanında belirgin küçülmeye sebep olmadığı görülmüştür. Nimodipin grubunun da aynı etkileri olduğu ancak pentoksifilin kadar etkin olmadığı görülmüştür. Sonuç: Pentoksifilin grubunun intimal hiperplaziyi önleme üzerine etkinliğinin belirgin olduğu ve ileri deneysel araştırmalar sonrasında tedavi protokollerinde yerinin olabileceği kanaati oluşmuştur. Anahtar Kelimeler: Rat, Anastomoz, İntimal hiperplazi, Restenoz, Nimodipin, Pentoksifilin, Vazoprotektif
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    Reliability and quality of online patient education videos for spina bifida
    (Elsevier Inc., 2023) Arpa, Abdurrahman; Özturk, Pınar Aydın
    Background: There is a growing trend among patients and their families to seek medical information online. Among the world's most popular websites, YouTube is ranked second. Our aim was to assess the reliability and quality of YouTube videos on spina bifida. Methods: Researchers searched the YouTube platform using 3 search keywords in February 2022. These were spina bifida, spina bifida treatment, and spina bifida surgery. The content of the first 35 videos for each search term was evaluated using the DISCERN scale. Two independent neurosurgeons with 6 years of experience in pediatric neurosurgery evaluated the content of the videos. Results: Of the total 105 videos, 58 met the inclusion criteria and were evaluated. Of these videos, 3 (6.5%) received a score between 3 and4. This suggests that the video is reliable but missing important information. Only one (2.1%) of the videos had a mean score of >4, which refers to a high-quality source of information. It has been found that the popularity of the video was not correlated with whether it was broadcasted by health professionals or whether it has surgical content. The correlation between video popularity and DISCERN score was not significant (P = 0.361/0.401 based on the number of views; P = 0.459/0.606 based on the number of likes). Conclusion: Based on the results of this study, patients and their families will generally encounter low-quality educational content on YouTube when searching for information about spina bifida. Since videos on spina bifida are insufficient, we recommend to universities, hospitals, and academic societies publish reliable video education content to support and optimize patient education, in line with approved tools such as DISCERN.
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    Retrospective evaluation and one year monitoring of 58 patients according to neural tube defect etiology
    (Czech Medical Association J.E. Purkyne, 2024) Arpa, Abdurrahman; Öztürk, Pınar Aydın; Asena, Muhammed; Aktaş, Ulaş; Güler, Tuğba Morali
    Aim: Neural tube defects (NTDs) are a group of diseases caused by genetic and environmental factors; however, their complete etiology remains unknown. Folate deficiency, medications, maternal diseases and a low socioeconomic status, as well as genetic factors, are known risk factors for NTD. The purpose of this study was to determine possible etiologic factors of NTD and to evaluate patients after 1 year of monitoring. Methods: We retrospectively analyzed 58 patients who were operated as neonates at our hospital in 2017. Results: Of 58 patients, 60.3% were female and 39.7% were male. The frequency of birth abnormalities was higher in mothers aged > 35 years. Overall, 56.9% of the pregnancies occurred during the hot months and 43.1% during the cold months according to the neurulation period. Encephalocele was detected in 3.4%, myelomeningocele in 31% and myeloschisis in 63.8% of patients. Of all patients, 60.3% were diagnosed with hydrocephalus either at birth or at a 1-year follow-up, and they wore a shunt. Conclusion: The results indicate that NTD incidence is higher among females and exerts a high myeloschisis frequency. Other risk factors include kin marriage, family history of NTD, a maternal age outside the range of 19–34 years and mothers with 0 Rh+ blood type. Furthermore, there was a high incidence of abnormalities in the urinary and other systems, which should be considered during patients’ monitoring and surgery. Additionally, there may be a correlation between a sac size and hydrocephalus as well as between myeloschisis and a risk of hydrocephalus.
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    Tavşanlarda deneysel subaraknoı?d kanama modelı?nde IV %20 mannı?tolün serebral vazospazm üzerı?ne etkı?leri
    (Dicle Üniversitesi Tıp Fakültesi, 2023) Sanrı, Ömer; Yılmaz, Adil; Arpa, Abdurrahman; Öztürk, Pınar Aydın; Turan, Yahya
    Amaç: Taradığımız tüm ingilizce literatürde Subaraknoid Kanama (SAK) tedavisinde sıklıkla kullanılan %20 mannitolün serebral vazospazm üzerine etkilerinin incelenmediğini gördük. Bu nedenle bu çalışmada tavşanlarda deneysel SAK modelinde bir osmotik diüretik ajan olan ve kafa içi basınç artışı sendromu (KIBAS) durumunda sıklıkla kullanılan intravenöz %20 mannitol uygulamasının serebral vazospazm üzerine etkilerini incelemeyi amaçladık. Yöntemler: Çalışmamızda 28 adet Yeni Zelanda beyaz tavşanı kullanıldı. Tavşanlar Grup 1 (kontrol, n=7),Grup 2 (SAK (+), n=7),Grup 3 (SAK(-)%20 Mannitol (+), n=7), Grup 4 (SAK(+), %20 Mannitol(+), n=7) olmak üzere 4 gruba ayrıldı. Deneysel SAK modeli Grup 2 ve 4’teki tavşanların sisterna magnalarına otolog arteryel kan verilerek SAK oluşturuldu. Grup 3 ve 4’teki tavşanlara 1gr/kg/gün % 20 mannitol 4 eşit doza bölünerek 3 gün süre ile intravenöz olarak verildi. Tüm tavşanlar SAK oluşumunu takip eden 72.saatte sakrifiye edilerek beyin beyin sapı global olarak çıkarılıp fiske edildi. Deneklerin baziller arterlerinden elde edilen kesitler Hematoksilen ve Eosin ile boyanarak mikroskop altında incelendi. Bulgular: Elde edilen baziller arter kesitlerinde damar kalınlığı, damar çapı, lümen çapı, lümen kesit alanı ve damar toplam alanları ölçüldü. Grup 1,3,4 arasında damar duvar kalınlığı yönünden anlamlı fark saptanmadı(p=0,01). Tüm gruplar arasında en fazla damar duvar kalınlığı grup 2’de ölçüldü. Grup 1 ve 3 karşılaştırıldığında baziller arter lümen çapları arasında anlamlı fark saptanmadı (p=0,46). Grup 1,2,4 lümen çapları arasında fark saptanmadı. Baziller arter lümen kesit alanları arasında da anlamlı fark saptanmadı (p=0,08). Sonuç: %20 Mannitol tedavisinin Subaraknoid kanama deneysel modeli sonrası gelişen serebral vazospazm üzerine olumlu veya olumsuz herhangi bir etkisinin olmadığı saptandı.