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Öğe Clinical and histopathological features of patients with cicatricial marginal alopecia(Turkiye Klinikleri, 2014) Akkurt Z.M.; Uçmak D.; Do?ruk Kaçar S.; Alabalik U.; Karabulut P.; Türkçü G.; Arica M.Objective: The aim of this study was to investigate the clinical and histopathologic characteristics of patients presenting with band-shaped alopecia of the temporal and frontal areas who had no history of traction. Material and Methods: Patients with cicatricial marginal retrospective study were included in this retrospective study. Severity of disease was classified as mild, moderate and severe according to the density of hair and size of lesions. Classification of the alopecia was made as follows: "bitemporal" in patients with involvement of only the temporal areas, "band-like" in patients with involvement of both temporal areas and the frontal area, and "other" in patients which did not fit the previous classifications. Dermoscopic findings were noted. Previous biopsy samples were restained with Masson Trichrome, CD3, CD1a, CD20 and CD68 and re-evaluated. Results: A total of 20 patients were included in the study. The mean age of the patients was 27,68 (15-41) years and the mean disease duration was 2,33 years. The most frequently reported symptoms were moderate-to-severe pruritus and mild pain. The disease was mild in nine, moderate in seven and severe in four patients (45,0%, 35,0% and 20,0%, respectively). The frontal and temporal hairline was intact and had in all patients. Eight patients had a bitemporal, eight had a band-like pattern of disease, whereas the rest were of other patterns. No signs of inflammation, including erythema, pustules, were observed on the lesions. On dermoscopy, decreased hair density, decreased number of follicles and hair shafts with reduced diameters were seen in all patients. Histopathologic findings of the 14 patients who had consented to biopsy were all similar. Decrease in number of hair follicles, perifollicular fibrosis and retention of sebaceous glands were notable findings. Inflammatory cells were very scarce. Conclusion: Cicatricial marginal alopecia is a type of alopecia seen in females which can seriously affect the cosmetic well-being of patients. An intact hairline and lack of inflammation are characteristic properties of the disease. Copyright © 2014 by Türkiye KlinikleriÖğe Evaluation of clinical and epidemiological features of children with facial viral warts(Dermatologia Pediatrica, 2014) Uçmak D.; Akkurt Z.M.; Dal T.; Acar G.; Arica M.Verrucae are viral lesions commonly encountered in the pediatric population. They occur relatively rarely on the face. The occurence of verrucae in the facial region leads to limitation in treatment modalities and increases patient discordance. The clinical and epidemiological data of 37 patients (26 females) seen at the Dicle University Faculty of Medicine Dermatology outpatient clinics from January 2012 to January 2013 were reported. The mean age of the patients was 10.43±4.51 (range 4-18). The mean duration of lesions was 16.59±14.90 months. Number of lesions ranged from 1 to 50 (mean: 15.92). The most common localization on the facial area was the cheek in 23/37. Extrafacial involvement was present in 5/37 patients. The most common type of verruca in the facial region was verruca plana (50%). Before admission to our clinic, 56.8% had not received any form of treatment. Treatment modalities included reassurance - 16% -, cryotherapy -10.8% -, topical treatment with tretinoin cream, salicylic acid + 5-FU solution - 5.4% - and cauterization -1%-. Twelve of the 21 patients who had not previously received therapy had periorbital lesions. Positive correlation was present between age and duration of lesions (p < 0.01, r = 0.42).Öğe Generalized pustular psoriasis in two children: Acitretin therapy: Case report(Turkiye Klinikleri, 2014) Uçmak D.; Akkurt Z.M.; Türkçü G.; Acar G.; Akdeniz S.; Arica M.Von Zumbusch type pustular psoriasis is rarely seen in pediatric patients. Attacks of pustular psoriasis are characterized by fever that lasts several days, followed by sudden onset of pustules. The pustules are disseminated over the trunk and extremities, including the nail beds palms, and soles. Acitretin, alone, or combined with oral corticosteroids, is the first-line treatment method. Methotrexate or cyclosporine may also be used. Acitretin is a second generation aromatic retinoid. It takes effect by regulating keratinocyte proliferation and differentiation. A two-yearold girl and a three-year-old boy, presented with widespread pustules on an erythematous background, accompanied by fever and leukocytosis. Skin and blood cultures were negative. A diagnosis of Von Zumbusch type pustular psoriasis was made. We present two pediatric cases of generalized pustular psoriasis responding to acitretin rapidly and effectively. Copyright © 2014 by Türkiye Klinikleri.Öğe Oral fluconazole in the treatment of tinea corporis and/or cruris and tinea pedis(1996) Arica M.; Pinar O.Z.; Soyaldi M.; Derici M.Design.- Thirty-one who had tinea corporis and/or tinea cruris and 12 patients who had tinea pedis were treated with oral fluconazole. All patients were given once-weekly doses of oral fluconazole 150 mg for four weeks. Results.- After treatment, 22 of 31 (71%) patients who had tinea corporis or tinea cruris were clinically cured, 6 (19.4%) patients were improved and 3 (9.6%) patients failed, 9 of 12 (75%) patients who had tinea pedis were improved and 3 (25%) patients failed. Conclusion.- It is concluded that fluconazole is an effective oral antifungal drug for the treatment of tinea corporis and/or cruris.Öğe Recombinant interferon alpha-2a in the treatment of classic Kaposi's sarcoma(1996) Arica M.; Arslan A.; Mevlitoglu I.; Aytekin S.; Derici M.Observations. A case of classic Kaposi's Sarcoma (AIDS non related) in a 51-year-old man is presented. He was treated with recombinant interferon alpha-2a (6 million units/day) three times per week intramuscularly for 3 months. All lesions were completely resolved after treatment.
