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    Effects of isotretinoin on obsessive compulsive symptoms, depression, and anxiety in patients with acne vulgaris
    (Taylor & Francis Ltd, 2012) Yesilova, Yavuz; Bez, Yasin; Ari, Mustafa; Kaya, Mehmet Cemal; Alpak, Gokay
    Background: Depression, anxiety, and obsessive compulsive symptoms are known to be common among patients with acne vulgaris. In contrast to earlier reports, a number of recent studies suggested isotretinoin to be beneficial for depression and anxiety symptoms in acne patients. Moreover, its effects on obsessive compulsive symptomatology are still widely unknown. Objectives: To examine the effects of isotretinoin treatment on obsessive compulsive symptoms, depression, and anxiety in acne vulgaris patients. Methods: The Hospital Anxiety and Depression Scale, Maudsley Obsessive Compulsive Questionnaire, and Sheehan Disability Scale were administered to 43 patients with acne vulgaris who accepted isotretinoin treatment and agreed to participate in the study. Severity of acne was evaluated with Global Acne Grading System. Thirty-three patients completed 6 months treatment with oral isotretinoin at 0.5-1.0 mg/kg daily doses. Measurements were repeated at the end of 6 months. Results: Depression, anxiety, and obsessive rumination symptoms were significantly improved after isotretinoin treatment. On the other hand, obsessive doubting of acne patients was worse at the end of the treatment. There was no significant change in disease related disability of patients. Conclusion: Besides worsening of obsessive doubting, successful treatment with oral isotretinoin seems to be related with improvement in depression, anxiety, and obsessive rumination symptoms in acne vulgaris patients. These changes were not reflected in the disability level that acne patients have reported.
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    Effects of Isotretinoin on Social Anxiety and Quality of Life in Patients with Acne Vulgaris: A Prospective Trial
    (Croation Dermatovenerological Soc, 2012) Yesilova, Yavus; Bez, Yasin; Ari, Mustafa; Turan, Enver
    Social anxiety is common in acne patients and the effects of isotretinoin treatment on social anxiety symptoms have not yet been thoroughly investigated. The aim of the study was to assess the effects of isotretinoin treatment on the quality of life and social anxiety symptoms in a group of acne vulgaris patients. The Liebowitz Social Anxiety Scale (LSAS) and Short Form-36 (SF-36) were administered to 39 (24 female and 15 male) patients with acne vulgaris who accepted isotretinoin treatment and agreed to participate in the study. The severity of acne was evaluated using the Global Acne Grading System. Thirty patients completed 6-month treatment with oral isotretinoin at 0.5-1.0 mg/kg daily doses. Measurements were repeated at the end of 6 months. Acne significantly improved over time in the study group. The mean performance avoidance score in LSAS and mean pain and social functioning scores in SF-36 were significantly better at the end of isotretinoin treatment. In conclusion, isotretinoin treatment improves the quality of life and social anxiety symptoms in acne patients.
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    High plasma nesfatin-1 level in patients with major depressive disorder
    (Pergamon-Elsevier Science Ltd, 2011) Ari, Mustafa; Ozturk, Oktay Hasan; Bez, Yasin; Oktar, Suleyman; Erduran, Dudu
    Aim: In the present study, our aim was to determine the changes in the plasma concentrations of a recently discovered peptide hormone nesfatin-1 in patients with major depressive disorder and then to make a comparison with the control group. Method: Subjects in the patient group were randomly selected from Mustafa Kemal University, Medical School, Research and Training Hospital, Psychiatry Department, Outpatient Clinic and subjects in the control group were selected from healthy volunteers. Healthy control subjects were matched in terms of weight and body mass index. Hamilton Depression Rating Scale (HAM-D) was applied to both groups. ELISA method was used for measurement of plasma nesfatin-1 levels. Results: The average nesfatin-1 level was statistically higher in patients with major depressive disorder than in the control group (p<0.001). A positive correlation was observed between plasma nesfatin-1 levels and HAM-D scores both in the patient group (r = 0.59, p<0.001) and in the control group (r = 0.58, p<0.001). Conclusion: Our findings suggest a possible relationship between major depressive disorder and high plasma nesfatin-1 level. (C) 2010 Elsevier Inc. All rights reserved.
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    Increased Plasma Nesfatin-1 Levels in Patients with Obsessive Compulsive Disorder
    (Kure Iletisim Grubu A S, 2012) Bez, Yasin; Ari, Mustafa; Ozturk, Oktay Hasan; Oktar, Suleyman; Can, Yesim
    Increased plasma nesfatin-1 levels in patients with obsessive compulsive disorder Objective:To determine and compare the plasma nesfatin-1 (a satiety peptide) levels of patients with obsessive compulsive disorder (OCD) and healthy control subjects. Method: Plasma nesfatin-1 levels of 31 patients with OCD (18 females, 13 males) and 28 healthy control subjects (16 females and 12 males) similar to the study group in terms of weight, age, and gender were measured in this study. Severity of obsessions and compulsions both in OCD patients and control subjects were determined by using Yale-Brown Obsessive Compulsive Scale (Y-BOCS). ELISA method was used to measure plasma nesfatin-1 levels. Results: Median plasma nesfatin-1 levels in patients with OCD and healthy control subjects were 4.61 ng/ml (min-max: 1.28-8.11) and 2.0 ng/ml (min-max: 0.11-4.98) respectively. The observed difference in plasma nesfatin-1 levels between two groups was statistically significant (p<0.001). No statistically significant correlation was observed between Y-BOCS scores and plasma nesfatin-1 levels either in the study group (r=0.205, p=0.27) or in the control group (r=0.335, p=0.071). Conclusion: Increased plasma nesfatin-1 levels observed in patients with OCD suggest a potential role to nesfatin-1 in anxiety states besides its previosly known anorexigenic effects.
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    Monday Anxiety in Office Workers
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2011) Bez, Yasin; Emhan, Abdurrahim; Ari, Mustafa; Ozen, Sakir
    Objective: In this study, comparison of state and trait anxiety levels of office workers on monday and on thursday was aimed. Method: On monday morning, sociodemographical form, State Anxiety Inventory (SAI), Trait Anxiety Inventory (TAI) and Beck Depression Inventory (BDI) were delivered to the 230 office workers. The data collected from 144 participants were usable. On thursday morning (3 days after) anxiety inventories were delivered again to these 144 workers. Complete and valid forms were collected from 61 participants. Results: The mean SAI scores of 61 participants on monday and on thursday were 44.4+10.2 and 42.2+9.9 (t= 2.226, p= 0.030) respectively; whereas their TAI scores were 44.7 +/- 8.8 and 43.0 +/- 8.2 (t= 2.123, p= 0.038) respectively. Mean BDI scores was 14.4 +/- 10.5. Mean TAI scores of workers both on monday and thursday were higher than managers'. Similarly, mean BDI score of workers on Monday was also higher than managers'. Mean TAI scores was higher in middle aged workers than youngs and higher in women than men. Additionally, mean SAI and TAI scores of high school graduates were higher than university graduates'. Conclusion: Relatively higher levels of anxiety on monday was found to be associated with woman gender, being over middle ages, longer job experience in the same work, lower education level, and being blue collar employee.
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    Plasma Nesfatin-1 Level May Be Associated with Disease Severity in Patients with Panic Disorder
    (Kure Iletisim Grubu A S, 2010) Bez, Yasin; Ari, Mustafa; Ozturk, Oktay Hasan; Oktar, Suleyman; Can, Yesim; Sogut, Sadik
    Objective:We have compared the plasma levels of the recently discovered peptide hormone nesfatin-1 between patients with panic disorder (PD) and healthy control subjects. Method: The subjects in the patient group were selected from the patients who presented to the psychiatry outpatient clinic of a university hospital and were diagnosed with PD. Healthy subjects similar to the patient group in terms of age, gender, weight, and BMI constituted the control group in this study. The Panic-Agoraphobia Scale (PAS) was applied to all subjects in both groups. Blood samples were collected to measure plasma nesfatin-1 level by using ELISA method. Results: Mean plasma nesfatin-1 level (4.66 +/- 2.39 ng/ml in patient group, 2.13 +/- 1.52 ng/ml in control group) was higher in patients with PD than in the control group (p<0.001). A positive correlation between PAS scores and plasma nesfatin-1 levels was found in the patients with PD. Conclusion: There may be a relationship between disease severity and plasma nesfatin-1 levels in panic disorder patients. Future studies investigating this relationship are needed.
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    Predictive Value of Obsessive Compulsive Symptoms Involving the Skin on Quality of Life in Patients with Acne Vulgaris
    (Acta Dermato-Venereologica, 2013) Bez, Yasin; Yesilova, Yavuz; Ari, Mustafa; Kaya, Mehmet Cemal; Alpak, Gokay; Bulut, Mahmut
    Acne is one of the most common dermatological diseases, and obsessive compulsive disorder is among the most frequent psychiatric conditions seen in dermatology clinics. Comorbidity of these conditions may therefore be expected. The aim of this study was to measure obsessive compulsive symptoms and quality of life in patients with acne vulgaris, compare them with those of healthy control subjects, and determine whether there is any predictive value of obsessive compulsive symptoms for quality of life in patients with acne. Obsessive compulsive symptoms and quality of life measurements of 146 patients with acne vulgaris and 94 healthy control subjects were made using the Maudsley Obsessive Compulsive Questionnaire and Short Form-36 in a cross-sectional design. Patients with acne vulgaris had lower scores for physical functioning, physical role dysfunction, general health perception, vitality, and emotional role dysfunction. They also had higher scores for checking, slowness, and rumination. The only predictor of physical functioning and vitality dimensions of health-related quality of life in these patients was rumination score. Obsessive compulsive symptoms in patients with acne vulgaris are higher than in controls, and this may correlate with both disease severity and quality of life for patients.
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    Serum adiponectin and resistin levels in patients with obsessive compulsive disorder
    (Elsevier, 2012) Ari, Mustafa; Ozturk, Oktay Hasan; Bez, Yasin; Arica, Secil; Can, Yesim; Erduran, Dudu
    We aimed to investigate the changes in serum adiponectin and resistin levels in patients with obsessive compulsive disorder and control groups. The serum adiponectin and resistin levels of 29 patients (16 females, 13 males) with obsessive compulsive disorder and weight, age and sex-matched 31 healthy controls (17 females, 14 males) were determined. Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was applied to all groups. ELISA method was used to measure adiponectin and resistin levels. The mean adiponectin level was 11.92 +/- 2.04 ng/ml and resistin level was 13.23 +/- 2.78 ng/ml in obsessive compulsive disorder group, while it was 18.81 +/- 5.24 ng/ml and 8.17 +/- 2.53 ng/ml in control group. Changes in plasma adiponectin and resistin levels in obsessive compulsive disorder may have implications about possible cardiovascular and metabolic abnormalities seen in obsessive compulsive patients. (C) 2011 Published by Elsevier B.V.