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    Are oxidative stress markers useful to distinguish schizoaffective disorder from schizophrenia and bipolar disorder?
    (Cambridge Univ Press, 2014) Bulbul, Feridun; Virit, Osman; Alpak, Gokay; Unal, Ahmet; Bulut, Mahmut; Kaya, Mehmet Cemal; Altindag, Abdurrahman
    Objective Schizoaffective disorder is a disease with both affective and psychotic symptoms. In this study, we aimed to compare oxidative metabolism markers of schizoaffective disorder, bipolar disorder and schizophrenic patients. Furthermore, we also aimed to investigate whether schizoaffective disorder could be differentiated from schizophrenia and bipolar disorder in terms of oxidative metabolism. Methods Total oxidant status (TOS) and total antioxidant status (TAS) were measured in the blood samples that were collected from schizoaffective patients (n = 30), bipolar disorder patients (n = 30) and schizophrenic patients (n = 30). Oxidative stress index (OSI) was calculated by dividing TOS by TAS. Results TOS and OSI were found to be higher in patients with schizoaffective disorder compared with those in schizophrenia and bipolar disorder patients. TAS was not significantly different between the groups. Conclusion Schizoaffective disorder was found to be different from bipolar disorder and schizophrenia in terms of oxidative parameters. This result may indicate that schizoaffective disorder could differ from bipolar disorder and schizophrenia in terms of biochemical parameters. Increased TOS levels observed in schizoaffective disorder may suggest poor clinical course and may be an indicator of poor prognosis.
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    Catatonia associated globe vesicale
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2012) Sahin, Sengul; Bulbul, Feridun; Unal, Ahmet; Bulut, Mahmut; Virit, Osman; Altindag, Abdurrahman; Savas, Haluk
    Catatonia is a syndrome that includes catalepsy, waxy flexibility, stupor, negativism, mutism, and echolalia. Side effects such as dehydration, malnutrition, constipation, flexion contractors and rhabdomyolysis may develop due to catatonia. Here, we aimed to report a case of globe vesicale associated with catatonia and the successful treatment of this case with benzodiazepine use and electroconvulsive therapy (ECT) treatment. As a result, the globe vesicale should be considered in patients presenting with catatonia and if present it should be treated urgently.
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    Childhood traumatic events and dissociation in university students
    (Taylor & Francis Ltd, 2009) Aydin, Yunus Emre; Altindag, Abdurrahman; Ozkan, Mustafa
    Objective. The purpose of this study was to determine the frequency of childhood traumatic events, to investigate its relationship with dissociation and other psychiatric symptoms and to examine the potential effect of family functioning on dissociative symptoms and general psychopathology in a Turkish university student sample. Methods. All participant completed Brief Physical and Sexual Abuse Questionnaire, Symptom Checklist-90-Revised (SCL-90-R), Dissociative Experiences Scale (DES) and Family Assessment Device (FAD). Results. The most frequent childhood trauma type was separation from caretaker (46.1%). Witnessing violence (33.1%), harsh punishment (21.2%) and substance abuse in family (10.5%) followed. Sexual abuse of incest type was seen in 6.3%. Students who reported childhood traumatic events had higher DES and SCL-90-R scores compared to those who did not. There were fair relationships between SCL-90-R and FAD scores. Conclusion. A history of childhood traumatic events may be related to increased level of dissociation and general psychopathology in university students. Other pathogenic family factors also may contribute to the development of psychiatric symptoms.
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    Effects of an antistigma program on medical students' attitudes towards people with schizophrenia
    (Wiley, 2006) Altindag, Abdurrahman; Yanik, Medaim; Ucok, Alp; Alptekin, Koksal; Ozkan, Mustafa
    People with schizophrenia are amongst the most stigmatized of those with mental illnesses. The purpose of this study was to examine whether an antistigma program which consists of education, contact, and viewing a film that depicts an individual with schizophrenia, can change attitudes towards people with schizophrenia. The antistigma program was carried out with first-year medical students (n = 25). Students' attitudes towards people with schizophrenia were assessed before and after the program. In parallel, a control group of first-year medical students were questioned (n = 35). Assessment was repeated after 1 month. Favorable attitudinal changes were observed in terms of 'belief about the etiology of schizophrenia', 'social distance to people with schizophrenia', and 'care and management of people with schizophrenia'. In contrast, no significant change was observed in the control group. Attitude changes tended to decrease at the 1-month follow up. These results suggest that attitudes towards schizophrenia could be changed favorably with this program. To sustain changed attitudes towards people with schizophrenia, antistigma programs should be offered on a regular basis.
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    Mental health aspects of Turkish women from polygamous versus monogamous families
    (Sage Publications Ltd, 2006) Ozkan, Mustafa; Altindag, Abdurrahman; Oto, Remzi; Sentunali, Esin
    Background: Polygamy is illegal in Turkey, but is common among rural villagers in the southeastern region. Polygamous marriage may have a negative effect on the wives involved. Aim: The purpose of this study was to determine the extent of the relationship between psychiatric disorder and polygamous marriage. Method: The mental status of 42 senior and 46 junior wives from polygamous marriages and 50 wives from monogamous marriages was evaluated using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) and Somatoform Dissociation Questionnaire (SDQ). Results: There was a statistically significant difference among senior, junior and monogamous wives in terms of the prevalence of somatization disorder. The prevalence of somatization disorder was the highest in polygamous senior wives. The mean total SDQ scores differed significantly among the three groups. It was the highest in senior wives. Conclusions: It is clear that the participants from polygamous families, especially senior wives, reported more psychological distress. It is essential to increase awareness of the significance of polygamous family structures among psychiatrists and other therapists.
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    Oxidative metabolism may be associated with negative symptoms in schizophrenia
    (Taylor & Francis Ltd, 2017) Gunes, Mehmet; Altindag, Abdurrahman; Bulut, Mahmut; Demir, Suleyman; Ibiloglu, Aslihan Okan; Kaya, Mehmet Cemal; Atli, Abdullah
    Objective: In the present study, we aimed to examine the relationship between the oxidative metabolism with disease severity, sociodemographic, and clinical characteristics in the patients with schizophrenia. Methods: Seventy-one patients with schizophrenia and 76 healthy volunteers were included in the study. Plasma total antioxidant level (TAL) and total oxidant level (TOL) were analyzed, and oxidative stress index (OSI) was calculated. Results: There was a statistically significant increase in TOL and OSI and decrease in TAL in the patients with schizophrenia compared to the controls (p <.05). There were positive, mild, statistically significant correlations between TOL, OSI, and Positive and Negative Syndrome Scale-Total scores (p =.01, p =.01, respectively), Positive and Negative Syndrome Scale-Negative scores (p =.002, p =.001, respectively), Positive and Negative Syndrome Scale Global Psychopathology scores (p =.03, p =.03, respectively), and Clinical Global Impression-Severity Scale scores (p =.008, p =.009 respectively). OSI levels were significantly lower in the patients who were on treatment with atypical antipsychotics (AAP) compared to the patients who were on typical antipsychotics (TAP) and combined antipsychotic (CAP) agents (p =.032). Conclusions: Oxidative stress was higher in schizophrenia patients. The increased severity of negative symptoms was in line with the disruption in oxidative balance. Oxidative stress is quite lower in AAP users compared to the TAP and CAP users. One of the mechanisms underlying the fact that AAPs are more effective on negative symptoms than typical agents may be the positive effect on the oxidative stress.
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    Oxidative parameters in bipolar patients treated with electroconvulsive therapy and pharmacotherapy
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2013) Bulut, Mahmut; Altindag, Abdurrahman; Deveci, Zeliha; Kaya, M. Cemal; Bulbl, Feridun; Taskin, Abdullah; Kocamer, Sengul
    Electroconvulsive (ECT) is one of the most efficacious choice in the treatment of bipolar disorder. There is no study conducted on human being investigating the effect of ECT on oxidative balance in bipolar disorder. In the present study, we aimed to evaluate the oxidative parameters on bipolar inpatients who is treated with ECT and pharmacotherapy. 31 bipolar inpatients in psychiatry department of Gaziantep University and 35 healty volunteeers were included in the study. Total Antioxidant Status (TAS), Total Oxidant Status (TOS) of serum samples were measured and Oxidative Stress Index (OSI) were counted in Harran University Biochemistry Laboratory. In all patient group, bipolar manic episode and depressive episode patients; before ECT and after ECT there was no significant difference for oxidative parameters. Before ECT, TAS levels in bipolar depressive episode patients were significantly lower than the control group (z=-2.614, p= 0.009). But after ECT, there was no difference between these two groups (z=-1.558, p> 0.05). Before ECT, TOS levels in bipolar manic episode patients were significantly higher than the control group (z=-2.598, p= 0.009); after ECT, there was no difference between these two groups (z=-0.910, p> 0.05). Finally, when compared with controls, in bipolar depressive episode patients TAS levels were increased with ECT and pharmacotheraphy and in bipolar manic episode patients TOS levels were decreased. For more comprehensive results new studies are needed.
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    The relationship between clinical parameters and depression level in patients with myofascial pain syndrome
    (Oxford Univ Press, 2008) Altindag, Ozlem; Gur, Ali; Altindag, Abdurrahman
    Objective. Several studies and reviews have documented the high degree of comorbidity between depression and chronic pain. It was reported that chronic muscle pain is frequently accompanied by symptoms of depression. The purpose of this study was then to investigate the prevalence of major depression in chronic pain patients (CPP) with myofascial pain syndrome (MPS) and to investigate the relationship between some clinical parameters and level of depression, utilizing a healthy control group without MPS. Design/Setting/Patients. The study group consisted of 77 MPS patients (65 female, 12 male) and 72 healthy volunteers (60 female, 12 male). The diagnosis of MPS was based on clinical characteristics, examination findings, and ruling out other diagnoses. Major depressive disorder was diagnosed by a psychiatrist utilizing DSM-IV criteria. Levels of depression were obtained from the Beck Depression Inventory (BDI). Results. There was no significant difference between MPS patients and controls with respect to age and gender (P > 0.05). The mean age of the patients was 31.1 years (SD 9.8) and the mean age of controls was 29.7 years (SD 7.1). Major depression was more frequently found in CPPs with MPS (P < 0.001). BDI scores were higher in the MPS group than in controls (P < 0.001). There was a significant correlation between the severity of pain and depression level in patients with MPS (r = 0.654, P < 0.001). Conclusion. Major depression is found in MPS CPPs at a rate previously noted in the literature in mixed diagnoses CPPs. In addition, the severity of the depression may be related to perceived pain severity.