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    Clinical, Haematological and Biochemical Findings in Sheep Naturally Infected with Dermatophilus congolensis
    (Natl Information Documentation Centre, 2022) Simsek, Aynur; Kochan, Akin; Alp, Simten Yesilmen
    Dermatophilus congolensis infection in sheep is manifested as matted tufting, entanglement, hardening and loss of wool, and thickening and itching of the skin, altogether which eventually results in economic losses. We investigated the clinical, hematological and biochemical findings in sheep naturally infected with Dermatophilus congolensis. For this purpose, 35 infected Akkaraman sheep (aged: 3-4 years, belonging to a flock of 200 animals) were referred to Prof Dr. Servet SEKIN Polyclinic of the Dicle University, Veterinary Faculty with various skin problems were included. The infected sheep presented with crusted skin lesions, matted wool tufts, alopecia, and pruritus. Their biochemical serum analyses revealed increased serum alkaline phosphatase, alanine aminotransferase, lactate dehydrogenase, blood urea nitrogen, total protein, albumin and calcium levels, and decreased creatinine, sodium and potassium levels in comparison with the control animals. The infected animals were treated with parenteral amoxicillin/clavulanic acid (Synulox (R)-Zoetis; 8.75 mg/kg body weight, i.m., once daily for 5 days) and local povidone-iodine (Batimer (R)-Esmira) administration, and observed for response to the treatment regimen. We found that Dermatophilus congolensis infection causes skin and wool damage in sheep, along with alteration in the serum biochemical parameters.
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    EFFECTS OF DIETARY ADDITION OF CHLOROGENIC SUBSTANCES ON GROWTH PERFORMANCE, INTESTINAL MICROFLORA POPULATION AND SERUM BIOCHEMISTRY IN BROILERS
    (Univ Agricultural Sciences & Veterinary Medicine Bucharest, 2016) Denli, Muzaffer; Akyildiz, Serhat; Alp, Simten Yesilmen; Cardozo, Paul W.
    The aim of this study was to evaluate dietary effects of chlorogenic substances (Igusafe) on growth performance, intestinal microflora population and serum biochemistry in broilers. A total of 144 Ross 308 one-day-old male broiler chicks were randomly allocated to 3 treatment groups consisting of 8 replications of 6 chicks per pen for 42 days. There treatments were used: chicks were fed by basal diet as control group, basal diet plus 80 mg Igusafe/kg diet, and basal diet and 160 mg Igusafe/kg diet. Results showed that the addition of 80 mg Igusafe to the diet resulted in significantly higher body weight gains and lower aspartate amino transferase (AST) and serum total protein (TP) concentrations compared with control group (P < 0.05). Intestinal tract weight was also significantly higher in the group fed 160 mg Igusafe/kg diet (P < 0.05). Supplementing both levels of Igusafe significantly reduced Escherichia coli count (P < 0.05). There were no treatments effects on carcass yield, liver weight and Lactic acid bacteria population (P > 0.05). In conclusion, our results indicated that supplementation of Igusafe may be useful as enhancer of growth performance by reducing Escherichia coli count with a positive trend to decrease the broilers mortality.
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    The effects of Mannheimia haemolytica and albendazole on marbofloxacin pharmacokinetics in lambs
    (Springer, 2019) Altan, Feray; Ipek, Duygu Neval Sayin; Corum, Orhan; Alp, Simten Yesilmen; Ipek, Polat; Uney, Kamil
    The study aimed to define the effects of M. haemolytica and a single oral dose of albendazole on the single-dose pharmacokinetics of marbofloxacin in lambs. The pharmacokinetic-pharmacodynamic integration of marbofloxacin was applied to describe a 3 mg/kg intramuscular dose in lambs. The 6 healthy and 12 naturally infected with M. haemolytica lambs (Akkaraman, males weighing 10-15 kg and aged 2-3 months) were used in this study. In the marbofloxacin group, 6 healthy lambs received marbofloxacin. In the albendazole group after 2 weeks washout period, the same animals received marbofloxacin on 1 h after albendazole. In the diseased marbofloxacin group, 6 lambs naturally infected with M. haemolytica received marbofloxacin. In the diseased albendazole group, 6 lambs naturally infected with M. haemolytica received marbofloxacin on 1 h after albendazole. The marbofloxacin and albendazole were administered each as a single dose of 3 mg/kg intramuscular and 7.5 mg/kg oral, respectively, in the respective groups. Plasma concentration of marbofloxacin was measured with HPLC-UV and pharmacokinetic parameters were analyzed by non-compartmental model. Albendazole did not change the pharmacokinetic profiles of marbofloxacin in healthy and diseased lambs. However, M. haemolytica affected the pharmacokinetics of marbofloxacin in diseased lambs, AUC(0-24)/MIC90 ratio was not found to be higher than 125, but C-max/MIC90 ratios was found to be higher than 10 for an MIC value of 0.25 mu g/mL in all groups. The marbofloxacin dose described in this study may not be effective for the treatment of infections due to M. haemolytica in lambs, with MIC <= 0.25 mu g/mL.
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    THE INFLUENCE OF OREGANO ESSENTIAL OIL ON EGG QUALITY AND EGG SHELL CONTAMINATION OF LAYING HENS KEPT IN FURNISHED CAGES
    (Univ Agricultural Sciences & Veterinary Medicine Bucharest, 2019) Denli, Muzaffer; Vural, Aydin; Alp, Simten Yesilmen
    The aim of this study was to determine the effects of adding oregano essential oils (OEO) to diets on egg quality and egg shell contamination of laying hens kept in furnished cages. For this aim 300 Atak-S at 31 weeks old laying hens were randomly divided into two groups negative control (NC; basal diet) and oregano essential oils (OEO; basal diets plus 150 mg/kg oregano essential oils) for 6 months. Dietary inclusion of OEO significantly decreased E.coli and Coliform contamination on egg shell (P<0.05). In addition, including diet with OEO improved means of egg weight comparing to the control (P<0.05). However, no significant differences in the internal quality characteristics of eggs were observed between two groups during the all experimental period (P>0.05). Results of the study indicated that the adding OEO to diets plays an important role in decreasing egg shell bacterial contamination.