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    Comparison of the Effectiveness of Thymoquinone, St. John Wort Oil and Silver Sulfadiazine in Experimental Burn Wounds
    (Oxford Univ Press, 2024) Canbaz, Yasin; Karakol, Percin; Erten, Remzi; Mercantepe, Tolga; Alp, Hamit Hakan; Canbaz, Esra Turan; Turel, Idris
    We aimed to compare the effectiveness of thymoquinone (TQ), the most important bioactive component of black cumin, St. John wort (SJW) oil, a traditional medicinal plant used in burns, and silver sulfadiazine (AgSD), a well-known antiinflammatory agent used in modern medicine, in an experimental burn rat-model. Sixty-three Wistar-Albino rats were randomly divided into 9 groups (n = 7). TQ and SJW were administered topically and systemically but AgSD was applied topically. Epithelialization, inflammatory cell response, granulation tissue, vascularization, and fibrosis were evaluated. Malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), vitamin E, 8-hydroxy-deoxyguanosine (8-OHdG), coenzyme Q10 (CoQ10) were analyzed in serum. Topical TQ accelerated the epithelialization, enabled granulation, vascularization, and fibrosis in wounds (P = .001). Topical and systemic TQ increased Vitamin E levels (P = .003) but reduced TOS and 8-OHdG levels (P = .001). Topical SJW reduced granulation and vascularization. Topical and systemic SJW decreased TOS, MDA, and 8-OHdG levels (P = .001) but increased TAS (P = .001) and Vitamin E levels (P = .003). Topical AgSD reduced TOS, 8-OHdG, and MDA levels (P = .001). Topical and systemic TQ demonstrated significant advantages in accelerating the wound healing process while also enhancing antioxidant defenses and reducing oxidative damage. SJW oil, particularly in topical application, improved epithelialization, and antioxidant status but showed less efficacy in systemic use. AgSD, while effective in reducing oxidative stress, was less successful in promoting wound healing and appeared to delay granulation and fibrosis. Thymoquinone offers superior protective and healing benefits, SJW is effective locally but less so systemically, and AgSD should be used cautiously, potentially combined with antioxidants to mitigate its negative impact on wound healing.
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    Öğe
    A cross-sectional measurement of endogenous oxidative stress marker levels in obsessive compulsive disorder
    (Aves Yayıncılık, 2022) Kuruhan, Faruk; Kamış, Gülsüm Zuhal; Alp, Hamit Hakan; Çim, Emine Füsun Akyüz; Atlı, Abdullah
    Background: There is a correlation between the increase in reactive oxygen radicals and the presence of specific mental illnesses. In this context, the objective of this study is to investigate the relationship between obsessive-compulsive disorder and the variations in the levels of several endogenous oxidative stress markers. Methods: Thirty obsessive-compulsive disorder patients were included in the study as the patient group, and 30 healthy volunteers of matching demographic characteristics were included in the study as the control group. Accordingly, the patient group consisted of 10 females and 20 males with a mean age of 29.5 ± 6.1 years, and the control group consisted of 15 females and 15 males with a mean age of 31.9±5.6 years. The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were compared using the independent samples t-test. The relationships between the serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were analyzed using the Pearson’s correlation coefficient. Results: The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the patient group were statistically significantly higher than those of the control group (P < .001). Statistically significant positive correlations were detected between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and nicotinamide adenine dinucleotide phosphate oxidase-4 levels (r=0.692, P=.001) and between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and malondialdehyde levels (r=0.563, P=.001). Conclusion: The results of this study indicated that oxidative stress and lipid peroxidation levels were higher in obsessive-compulsive disorder patients. Based on this finding, NOX-2 and NOX-4 levels can be used as indicators of endogenous oxidative stress in obsessive-compulsive disorder patients.