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A comparison of propofol-nitrous oxide and propofol-alfentanil anaesthesia in children
(1994) Tok D.; Ozyurek L.; Turhanoglu S.; Ali Ozyilmaz M.; Atasever J.
The haemodynamic effects, recovery from anaesthesia and side effects of continuous propofol infusion supplemented with nitrous oxide were compared with total intravenous anaesthesia using propofol and alfentanil in sixtytwo healthy children. The patients were randomly allocated to two groups. In group A, anaesthesia was induced with propofol, then propofol was given by continuous infusion supplemented with nitrous oxide for maintenance of anaesthesia. In group B, the induction with propofol and alfentanil was followed by a three stage stepped infusion of propofol and alfentanil mixture. Serious side effects were not observed in both groups during and after anaesthesia. There were statistically significant changes in systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and heart rate (HR) between the two groups, but the haemodynamic alterations were not considered to be serious (The mean values of haemodynamic data were not altered more than ± 20% of the baseline cardiovascular measurements).