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    Öğe
    Intima-media thickness and arterial distensibility in Behcet's disease
    (Sage Publications Inc, 2004) Alan, S; Ulgen, MS; Akdeniz, S; Alan, B; Toprak, N
    The etiology of Behcet's disease, a systemic vasculitis, is unknown. Vascular involvement may be seen in 25% of patients with Behcet's disease. Vasculitis make the prognosis of Behcet's disease severe. The aim of this study is to examine the structural and functional changes and relations of these changes with progression and prognosis of Behcet's disease. For this purpose, 40 patients with Behcet's disease and 40 healthy volunteer control subjects were analyzed, additionally patients with Behcet's disease were divided into 2 subgroups as those with vascular complications and those without vascular complications. Intima-media thickness and arterial distensibility were measured in all subjects with carotid artery ultra sonography, Carotid artery distensibility was significantly lower in the patient group compared to the control group (0.67 +/- 0.2, 0.93 +/- 0.4, p < 0.05), and carotid artery IMT was significantly higher (0.59 +/- 12, 0.80 +/- 0.11, p < 0.05). A statistically significant increase in IMT has been detected (0.77 +/- 11, 0.86 +/- 11, p < 0.05) in patients with Behcet's disease with vascular involvement compared to patients with Behcet's disease without vascular involvement, arterial distensibility in patients with vascular disease was similar with those who has no vascular disease (0.69 +/- 0.25, 0.63 +/- 0.25, p > 0,05). There was a significant negative linear regression between arterial distensibility and systolic blood pressure (SBP) (B= -1 X 10(-2), p < 0.05), and a significant positive linear regression has also been found between IMT and SBP and diastolic blood pressure (DBP) and pulse pressure (PP) (B = 6.8 X 10(-3) for SBP, p < 0.05, B = 6.9 X 10(-3) for DBP, p < 0.05, B = 6 X 10(-3) for PP, p < 0.05). As a result, IMT increases and AD decreases in patients with Behcet's disease compared to results in the control group. Although more studies are required for this subject, use of noninvasive parameters such as IMT and AD, which reflect the structural and functional characteristics of vasculature, may be useful to define disease progression and subjects at high risk.
  • [ X ]
    Öğe
    Relation between coronary artery disease, risk factors and intima-media thickness of carotid artery, arterial distensibility, and stiffness index
    (Westminster Publ Inc, 2003) Alan, S; Ulgen, MS; Ozturk, O; Alan, B; Ozdemir, L; Toprak, N
    Atherosclerosis is a diffuse process that involves vessel structures. In recent years, the relation of noninvasive parameters such as intima-media thickening (IMT), arterial distensibility (AD), and stiffness index (SI) to cardiovascular diseases has been researched. However, we have not found any study that has included all these parameters. The aim of this study is to examine the relation between the presence of coronary artery disease (CAD) and its risk factors to AD, SI, and IMT, which are the noninvasive predictors of atherosclerotic process in the carotid artery. Included in the study were 180 patients who were diagnosed as having CAD by coronary angiography (those with at least; greater than or equal to 30% stenosis in the coronary arteries) and, as a control group, 53 persons who had normal appearing coronary angiographies. IMT, AD, and SI values of all the patients in the study were measured by echo-Doppler imaging (AD formula = 2 x (AoS-AoD)/PP x AoD, SI formula = (SBP/DBP)/([AoS - AoD]/AoD). Significantly increased IMT (0.82 +/-0.1, 0.57 +/-0.1, p<0.05), decreased AD (0.25 +/-0.9, 0.37 +/-0.1, p<0.05), and increased SI (13 +/-4, 8 +/-3, p<0.05) values were detected in the CAD group compared to the control group. A significant correlation was found between IMT and presence of diabetes mellitus (DM), systolic blood pressure, total cholesterol, and presence of plaque in carotids, and age. In the coronary artery disease group there was a significant correlation between AD and age, systolic blood pressure, and HDL cholesterol levels, while there was no significant correlation with plaque development. A significant correlation was also found between stiffness index and systolic blood pressure and age; however, there was no relation between number of involved vessels and IMT, AD, and SI. We found sensitivity, specificity, and positive predictive and negative predictive values for CAD diagnosis to be 70%, 75%, 77%, and 66%, respectively. In CAD cases, according to data in this study, IMT and SI increased while AD decreased, and this was detected by carotid artery Doppler ultrasonography. Therefore, it was concluded that these cheaper, noninvasive, and easily available parameters could be used in early diagnosis of CAD.