Yazar "Alabalik, U." seçeneğine göre listele

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    Dermoscopic evaluation of two patients with lupus miliaris disseminatus faciei
    (Wiley-Blackwell, 2014) Ayhan, E.; Alabalik, U.; Avci, Y.
    Lupus miliaris disseminatus faciei (LMDF) is a chronic and uncommon inflammatory dermatosis, characterized by yellowish-red papules, especially on the face and around the eyelids. It is considered to be a reaction to destroyed hair follicles. We dermoscopically evaluated two patients diagnosed with LMDF. Dermoscopy revealed follicular keratotic plugs and vascular structures. We discuss these cases and other diseases dermoscopically showing keratotic plugs.
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    Effect of hyperbaric oxygen therapy on healing in an experimental model of degloving injury in tails of nicotine-treated rats
    (Sage Publications Ltd, 2013) Demirtas, A.; Azboy, I.; Bulut, M.; Ucar, B. Y.; Alabalik, U.; Ilgezdi, S.
    The aim of this study was to investigate the effect of hyperbaric oxygen (HBO) therapy on healing in an experimental model of a degloving injury of the tails of nicotine-treated rats. Thirty-two male Sprague-Dawley rats were randomized to four groups (n = 8): nicotine (group 1); HBO (group 2); nicotine + HBO (group 3); and control (group 4). The mean length of the necrotic parts of the tails at the degloving injury site was significantly higher in group 1 compared with groups 2, 3, and 4, and was significantly lower in group 2 compared with groups 1, 3, and 4. The mean histopathological stage of ulcers at the degloving injury site was statistically significantly higher (more severe) in group 1 compared with groups 2, 3, and 4, and was statistically significantly lower in group 2 compared with groups 1, 3, and 4. It appears that the negative effects of nicotine on wound healing in degloving injuries are negated by the positive effects of immediate HBO therapy.
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    Effects of caffeic acid phenethyl ester on cisplatin ototoxicity
    (Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2016) Ozbay, M.; Sengul, E.; Kinis, V.; Alabalik, U.; Yilmaz, B.; Topcu, I.
    Purpose: To report histological and electrophysiological data in rats treated with cisplatin and caffeic acid phenethyl ester. Methods: We randomly divided 28 Wistar rats into four groups of seven, to be treated as follows: control (saline), cisplatin, CAPE and cisplatin-CAPE. Distortion product otoacoustic emission (DPOAE) measurements were performed on day one (before drug administration) and day five under anaesthesia. All animals were killed under general anaesthesia on day five after the DPOAE measurement. The cochleae of each rat were histopathologically and immunohistochemically evaluated. Results: The outer hair cells were mostly preserved in the control and CAPE groups. Moderate -to -severe and mild -to moderate hair cell losses were detected in the cisplatin and cisplatin-CAPE groups, respectively. DPOAE assessments revealed significant deterioration in the cisplatin group (P < 0.05). The difference between the cisplatin and cisplatin-CAPE groups was statistically significant (P < 0.05). Conclusion: CAPE prevents cisplatin ototoxicity
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    THE EFFECTS OF THYMOQUINONE TREATMENT AGAINST CARBON MONOXIDE INTOXICATION
    (Lippincott Williams & Wilkins, 2016) Tokgoz, O.; Aycan, I. O.; Tufek, A.; Alabalik, U.; Evliyaoglu, O.; Yuksel, M. U.; Yildirim, Z. Baysal
    [Abstract Not Available]
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    Expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in the endometrium of patients with repeated implantation failure after in vitro fertilization
    (Verduci Publisher, 2014) Turgut, A.; Goruk, N. Y.; Tunc, S. Y.; Agaçayak, E.; Alabalik, U.; Yalinkaya, A.; Gul, T.
    AIM: To compare the immunohistochemical expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in repeated implantation failure (RIF) patients with normal fertile controls. PATIENTS AND METHODS: The study group consisted of primary infertile patients with RIF and normal fertile controls between January 2011 and February 2013. Endometrial samples received at the luteal phase were exposed to immunohistochemical staining for EMMPRIN antibodies. EMMPRIN expression of endometrial glandular epithelial cells, stromal cells and vascular endothelial cells were evaluated. The main outcome measure was defined as immunohistochemical score with regard to the severity and extent of staining. RESULTS: The study group consisted of 26 primary infertile patients, whereas the control group consisted of 40 normal fertile controls. The fertile group was found to have stronger expression of EMMPRIN than the study group when endometrial glandular epithelial cells, stromal cells and vascular endothelial cells were evaluated with regards to the severity of staining (p < 0.001), the extent of staining (p < 0.001) and total staining score (p < 0.001). CONCLUSIONS: This is the first study showing low expression of EMMPRIN in the endometrial cells of the patients with RIF compared with fertile healthy controls. We suggest that reduced EMMPRIN expression in the human endometrium may lead to poor endometrial receptivity.
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    Fibroblast growth factor-1 expression in the endometrium of patients with repeated implantation failure after in vitro fertilization
    (Verduci Publisher, 2013) Sak, M. E.; Gul, T.; Evsen, M. S.; Soydinc, H. E.; Sak, S.; Ozler, A.; Alabalik, U.
    BACKGROUND: An examination of the alterations in Fibroblast Growth Factor-1 (FGF-1) expression in a group of repeated implantation failure after in vitro fertilization (IVF) patients, when compared to fertile patients. PATIENTS AND METHODS: Study group consisted of 24 patients with repeated implantation failure and 29 fertile control patients. Endometrial samples received at the luteal phase were exposed to immunohistochemical staining for the fibroblast growth factor-1 (FGF-1) with antibodies. RESULTS: In the study group all patients have primary infertility (n = 24), and the average duration of infertility was 3.9 +/- 1.3 years. The average recurrent IVF failure was 2.6 +/- 0.6 attemps. There were no significant differences in the histological data according to the Noyes classification (p = 0.226) and age (p = 0.231) between the patients in the study and control groups (n=29). The control group was found to have more severe expression of FGF-1 (< 0.001) than the study group when endometrial glandular epithelial cells, stromal cells and vascular endothelial cells were evaluated. CONCLUSIONS: Endometrial glandular epithelial cells, stromal cells and vascular endothelial cells of the control and study group were evaluated and it was found that the control group displayed a stronger expression of the FGF-1 (< 0.001). The expression of FGF-1 in the IVF implantation failure group is less than in the fertile group, which suggests that growth factors such as FGF-1 are important maternal factors effecting implantation.
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    Investigation of the effects of Enoxaparin, Fondaparinux, and Rivaroxaban used in thromboembolism prophylaxis on fracture healing in rats
    (Verduci Publisher, 2013) Demirtas, A.; Azboy, I.; Bulut, M.; Ucar, B. Y.; Alabalik, U.; Necmioglu, N. S.
    BACKGROUND: Today, there is a small number of studies on the effects of Enoxaparin and Fondaparinux used commonly in the prevention of venous thromboembolism on healing of fracture cases. AIM: The aim of this study was to investigate clinically, radiologically and histopathologically, the effects of Enoxaparin, Fondaparinux and Ri-varoxaban used in thromboembolism prophylaxis on fracture healing in a rat model of femur fracture. MATERIALS AND METHODS: Thirty-two male Sprague Dawley rats were randomized into four groups (n=8): the control group (Group 1), the Enoxaparin group (Group 2), the Fondaparinux group (Group 3), and Rivaroxaban group (Group 4). Under general anesthesia, a standard closed fracture was created in the left femur of each rat using an osteotome. Group 1 was given saline solution (1 cc/day, sc), Group 2 Enoxaparin (100 anti Xa IU/kg/day, sc), Group 3 Fondaparinux (0.2 mg/kg/day, sc), and Group 4 Rivaroxaban (3 mg/kg/day, po) for 21 days. After all rats were sacrificed at the end of day 21, their left femurs were disarticulated at the level of the hip and knee. The bony union was radiologically, clinically, and histopathologically evaluated. RESULTS: No differences were found between the groups in terms of clinical, radiological, and histopathological findings in fracture healing (p = 0.849, p = 0.731, and p = 0.395, respectively). CONCLUSIONS: Enoxaparin, Fondaparinux and Rivaroxaban used in thromboembolism prophylaxis cause no significant changes in fracture healing with short term follow up. Thus, they can be safely used in cases of fractures.